Comp A: CALIFORNIA CENTER OF BD-STEPS III FINDING CAUSES AND PREVENTIVES OF BIRTH DEFECTS

比较 A：加州 BD-STEPS III 中心寻找出生缺陷的原因和预防措施

• 批准号: 10764184
• 负责人: GARY M SHAW
• 金额: $ 60万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764184
• 关键词: Comp; CALIFORNIA; CENTER; BD; STEPS

ABSTRACT Birth defects are the leading cause of infant mortality in the US. Birth defects also have enormous associated emotional and economic costs. The California Center's research efforts, both independently and in collaboration with other Centers for Birth Defects Research and Prevention contributing to the National Birth Defects Prevention Study (NBDPS) and the Birth Defects Study to Evaluate Pregnancy Exposures (BD-STEPS), have been at the forefront of public health birth defects research. With this new funding opportunity, referred to here as “BD- STEPS III” to distinguish from earlier BD-STEPS programs initiated in 2013 (BD-STEPS I) and 2018 (BD-STEPS II), our Center will further enhance scientific understanding of the potential causes of specific birth defects, which will undoubtedly have important implications for risk assessment and prevention of common, costly, and deadly birth defects. In this application we propose the following aims: Aim 1: Enhance the epidemiologic public health research capacity of the Centers for Birth Defects and Research and Prevention by actively participating in BD-STEPS III in a region of the US that is highly diverse in its race/ethnicity, socioeconomic characteristics, and environmental exposures. Aim 2: Utilize data from BD-STEPS I-III, as well as the earlier NBDPS (and likely other data sources unique to California), to conduct rigorous collaborative and local studies that will identify potential modifiable risk factors for selected birth defects (and where appropriate, in combination with genetic susceptibility) to reduce the public health burden of birth defects in the US. The California Center is well-equipped to contribute to BD-STEPS III – it is a world leader in birth defects epidemiology and highly experienced in the development, data collection and dissemination of information from population-based studies of birth defects, exemplified by its outstanding performance within the CDC Centers for Birth Defects Research and its highly innovative research portfolio. The application describes how the California Center will accomplish Aims 1 and 2 and will thereby further the knowledge base about causes and prevention for human birth defects. The California Center has extensive experience conducting research related to the BD-STEPS III areas of focus, which include maternal chronic diseases and their treatment, infectious disease in pregnancy, and medications. We have proposed several analytic inquiries, complemented by the use of additional innovative datasets and analytic approaches, which will enable us to collaboratively continue elucidating the contribution of these and other modifiable risk factors to birth defects.

抽象的 先天缺陷是美国婴儿死亡率的主要原因。出生缺陷也有 巨大的相关情感和经济成本。加利福尼亚中心的研究工作， 独立并与其他中心合作进行出生缺陷研究，并 预防有助于国家出生缺陷预防研究（NBDPS）和出生 评估怀孕暴露（BD步骤）的缺陷研究一直处于 公共卫生出生缺陷研究。有了这个新的资金机会，这里称为“ BD- 步骤III”与2013年启动的早期BD-Steps程序区分开（BD-Steps I）和 2018年（BD-Steps II），我们的中心将进一步增强对潜力的科学理解 特定出生缺陷的原因无疑将对风险产生重要影响 评估和预防常见，昂贵和致命的先天缺陷。在此应用中，我们 提案以下目的： 目标1：增强出生中心的流行病学公共卫生研究能力 通过积极参与BD-Steps III的缺陷，研究和预防 美国在种族/种族，社会经济特征和 环境暴露。 AIM 2：利用BD步骤I-III的数据以及早期的NBDP（以及其他数据 加利福尼亚独有的资源），进行严格的协作和本地研究，以确定 作为选定先天缺陷的潜在可修改风险因素（在适当的情况下，合并 具有遗传敏感性），以减少美国出生缺陷的公共卫生燃烧。 加利福尼亚中心有能力为BD-Steps III做出贡献 - 它是世界领导者 出生缺陷可以流行病学，并且在开发，数据收集和 从基于人群的先天缺陷研究中传播信息，以此为例 CDC中心的出色表现及其高度 创新研究组合。该申请描述了加利福尼亚中心将如何 完成目标1和2，从而进一步将有关原因的知识基础和 预防人类出生缺陷。加利福尼亚中心有丰富的经验 与BD-Steps III重点领域有关的研究包括材料慢性疾病 以及他们的治疗，怀孕中的传染病和药物。我们提出了 通过使用其他创新数据集和 分析方法，这将使我们能够协作继续阐明贡献 这些以及其他可修改的危险因素到出生缺陷。