Northern California Acute Care Research Consortium (NORCARES)

北加州急症护理研究联盟 (NORCARES)

基本信息

批准号：
10552463
负责人：
KAREN G HIRSCH
金额：
$ 41.18万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10552463
关键词：
Accident and Emergency department Acute Admission activity Ancillary Study Applied Research Area Asian Black race California Cardiac Clinical Clinical Trials Clinical Trials Network Collaborations Communities Community Hospitals Critical Care Data Coordinating Center Development Education Emergency Care Emergency Department patient Emergency Medicine Emergency Situation Emergency department visit Emergency research Enrollment Ensure Ethnic Origin Event Faculty Fellowship Fostering Funding Future Gender Generations Geography Goals Good Clinical Practice Grant Growth Growth and Development function Health Hematology Heterogeneity Hispanic Hospitals Human Resources Infrastructure Institution Interdisciplinary Study Leadership Medical emergency Medicine Mentors Mentorship Mission Modeling Multi-Institutional Clinical Trial Multicenter Trials Native Hawaiian or Other Pacific Islander Neurologic Patient Care Patient-Focused Outcomes Patients Personal Satisfaction Persons Play Population Population Heterogeneity Positioning Attribute Productivity Quality Control Race Records Regulation Research Research Activity Research Infrastructure Research Personnel Research Proposals Research Subjects Resources Role Rural San Francisco Site Site Visit Solid Special Population Structure System Teacher Professional Development Training Training Programs Trauma Underrepresented Minority United States National Institutes of Health Universities Woman acute care career clinical trial participant data hub demographics design dissemination strategy diversity and equity ethnic diversity experience flexibility improved improved outcome injured innovation medical schools medical specialties meetings novel participant enrollment patient population pediatric emergency programs racial diversity respiratory rural setting symposium trauma centers

项目摘要

The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) was created to enable conduct of high-quality, multicenter clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, hematologic, and trauma emergency events. In this application, we propose the Northern California Acute Care Research Consortium (NORCARES) as a new SIREN Hub, with a Co-Hub and M-PI structure that includes UC Davis (Daniel Nishijima, MD, MAS), Stanford (Karen Hirsch, MD), and UC San Francisco (Robert Rodriguez, MD). These three institutions and PIs are well suited to lead a Hub, having demonstrated broad and sustained growth in their research programs and productivity over the past 20 years with robust research infrastructure to facilitate patient enrollment into trials. NORCARES includes 30 Spokes and 7 EMS systems across Northern California and adjacent areas with whom our investigators have previously collaborated. We have selected Spokes and EMS agencies with extensive research experience and infrastructure, drawing on large patient volumes with diverse racial and ethnic backgrounds, urban and rural geography, and academic and community hospitals. Annually across the NORCARES Hub, there are over 1.8 million ED visits, 520,000 prehospital 911 scene transports, and 21,000 trauma admissions. Compared to the US population, our Hub serves larger proportions of Black, Asian, Native Hawaiian and Pacific Islander, and Hispanic ED patients. We will ensure that NORCARES provides solid research infrastructure, training and oversight to our Spokes and EMS agencies. Our Hub will enroll substantial numbers of research subjects, maintain Good Clinical Practices, adhere to research regulations, and comply with quality control activities. We will collaborate with the other SIREN Hubs, the Data Coordinating Center, the Clinical Coordinating Center, and federal partners in all research activities. We will implement an innovative Junior Faculty Training Program to transform junior scholars into trial investigators, capable of designing and leading emergency care trials. We will seek to promote the careers of women and under-represented minorities in medicine faculty, who constitute 44% of our key personnel. With outstanding infrastructure and an innovative collaborative plan, our proposed Hub is uniquely positioned to boost enrollment and promote equity and diversity of patient populations and faculty in SIREN trials.

创建了创新急诊临床试验网络（SIREN）的策略，以实现高质量的多中心临床试验，以改善神经，心脏，呼吸道，血液学和创伤紧急事件的患者的结局。在此应用程序中，我们建议北加州急诊研究联盟（NORCARES）作为新的警笛枢纽，其中包括UC Davis（UC Davis（Daniel Nishijima，MD，MAS），Stanford（Karen Hirsch，MD）和Robert Sanfrancisco（Robert Rodriguez，Md）。这三个机构和PI非常适合领导枢纽，在过去的20年中，其研究计划和生产力持续增长，并在强大的研究基础设施中表现出了广泛的增长，以促进患者入学试验。 NORCARES在北加州和邻近地区包括30个辐条和7个EMS系统，我们的调查人员以前与之合作。我们已经选择了具有广泛研究经验和基础设施的辐条和EMS机构，这些辐条借鉴了具有不同种族和种族背景的大量患者，城市和农村地理位置以及学术和社区医院。每年在NORCARES枢纽中，有超过180万的ED访问，520,000个院前911场景运输和21,000次创伤。与美国人口相比，我们的枢纽为黑人，亚洲，夏威夷原住民和太平洋岛民以及西班牙裔ED患者提供了更大比例。我们将确保Norcares为我们的辐条和EMS机构提供可靠的研究基础设施，培训和监督。我们的枢纽将招募大量的研究对象，维持良好的临床实践，遵守研究法规，并遵守质量控制活动。我们将与其他警笛枢纽，数据协调中心，临床协调中心以及联邦合作伙伴合作。我们将实施创新的初级教师培训计划，以将初级学者转变为能够设计和领导急诊试验的试验研究人员。我们将寻求促进妇女的职业和代表不足的医学学院的职业，占我们关键人员的44％的职业。凭借出色的基础设施和创新的协作计划，我们提出的枢纽是在警报器试验中促进入学率和促进患者人群和教职员工多样性的独特位置。