Pesticide Exposures and Risk of Preterm Birth

农药接触和早产风险

• 批准号: 9094597
• 负责人: GARY M SHAW
• 金额: $ 30.39万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9094597
• 关键词: 37 weeks gestation; Africa South of the Sahara; Agriculture; Air Pollutants; Area; Arsenicals; California; Carbamates; Cessation of life; Chemicals; Childhood; Coupled; Data; Data Sources; Databases; Developed Countries; Developing Countries; Development; Electronics; Elements; Endocrine Disruptors; Environment; Environmental Exposure; Environmental Pollution; Epidemiologic Studies; Expenditure; Exposure to; Family; Fetus; Food; Frequencies; Gestational Age; Grouping; Halogenated Hydrocarbons; Health; Human; Individual; Infant; Knowledge; Location; Medical Economics; Neonatal; Outcome; Pesticides; Phenotype; Population; Pregnancy; Premature Birth; Premature Infant; Prevalence; Public Health; Race; Reporting; Research; Research Personnel; Resources; Review Literature; Risk; Risk Factors; Sentinel; Socioeconomic Status; Source; Structural Congenital Anomalies; System; Toxic Environmental Substances; Universities; Water; Woman; World Health Organization; age group; base; cost; epidemiologic data; experience; functional group; gastrointestinal; immunogenic; innovation; medical schools; pesticide exposure; population based; premature; reproductive; respiratory; social; toxicant

DESCRIPTION (provided by applicant): Preterm birth involves deliveries before 37 weeks gestation. Approximately 15 million babies are born preterm every year in the world with a global prevalence approximating 10%. Prevalence of preterm birth in the US is approximately 13% and has increased in the US for decades. Risk factors of spontaneous preterm birth remain largely mysterious. An array of environmental exposures has been evaluated as potential risk factors for preterm birth including pesticides. Pesticide use in the US represents more than $2 billion/year in expenditures and involves the application of >100 million pounds of chemicals in the environment. Many of these chemical compounds are reproductive toxicants. However, large-scale studies have not been done to investigate whether gestational pesticide exposures influence preterm birth. This important public health hypothesis has been under studied likely owing to the limited availability of exposure data coupled with the lack of good epidemiologic data on preterm births. We have identified the necessary elements to remedy this lack of information. Here we propose the largest and most rigorous population-based epidemiologic study ever conducted that targets a breadth of pesticide compounds for their influence on preterm birth. We propose the following aims: 1) To determine whether exposures to specific pesticides during pregnancy are associated with >100,000 women spontaneously delivering infants/fetuses prematurely and 2) To determine whether exposures to biologically-functional groupings (e.g., endocrine disruptors or developmental toxicants) and physiochemical groupings (e.g., carbamates, halogenated hydrocarbons, and arsenicals) of pesticides during pregnancy are associated with >100,000 women spontaneously delivering infants/fetuses prematurely. Using existing data sources, we are proposing an unprecedented and efficient opportunity to close this knowledge gap. This population-scale study will be conducted in the California San Joaquin Valley - an area that is referred to as the "food basket of the world" and as "the most productive agricultural region in the world." The San Joaquin Valley is an area with demonstrated extensive pesticide use and an area diverse in socioeconomic status and race/ethnic background. Our group has demonstrated capability to successfully carry out this project

描述（申请人提供）：早产涉及妊娠37周之前的分娩。全球每年大约有1500万婴儿出生，全球患病率约为10％。美国早产的患病率约为13％，数十年来美国有所增加。自发早产的危险因素在很大程度上仍然是神秘的。一系列环境暴露已被评估为包括农药在内的早产的潜在危险因素。美国的农药使用代表超过20亿美元的支出，涉及在环境中施加> 1亿磅的化学品。这些化合物中的许多是生殖有毒物质。但是，尚未进行大规模研究以调查妊娠农药暴露是否影响早产。由于暴露数据的可用性有限，并且缺乏对早产出生的良好流行病学数据，因此对这一重要的公共卫生假设进行了研究。我们已经确定了必要的要素，以弥补这种缺乏信息。在这里，我们提出了有史以来最大，最严格的基于人群的流行病学研究，该研究旨在针对农药化合物的广度，以影响其对早产的影响。 We propose the following aims: 1) To determine whether exposures to specific pesticides during pregnancy are associated with >100,000 women spontaneously delivering infants/fetuses prematurely and 2) To determine whether exposures to biologically-functional groupings (e.g., endocrine disruptors or developmental toxicants) and physiochemical groupings (e.g., carbamates, halogenated hydrocarbons, and arsenicals) of怀孕期间的农药与> 100,000名妇女自发地过早地交付婴儿/胎儿有关。使用现有的数据源，我们提出了一个前所未有且有效的机会来缩小这一知识差距。这项人口规模的研究将在加利福尼亚圣华金山谷进行，该地区被称为“世界上的食物篮”，并将其作为“世界上最有生产力的农业地区”。圣华金河谷（San Joaquin Valley）是一个具有广泛农药使用的地区，社会经济地位和种族/种族背景的地区各不相同。我们的小组已经证明了成功执行该项目的能力

项目成果

Residential agricultural pesticide exposures and risks of preeclampsia.

• DOI: 10.1016/j.envres.2018.03.020
• 发表时间: 2018-07
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Shaw GM;Yang W;Roberts EM;Aghaeepour N;Mayo JA;Weber KA;Maric I;Carmichael SL;Winn VD;Stevenson DK;English PB
• 通讯作者: English PB