STUDIES OF OCCUPATIONAL CANCER

职业癌症的研究

• 批准号: 3916728
• 负责人: A E BLAIR
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916728
• 关键词: China; Hodgkin's disease; adenocarcinoma; agriculture worker; astrocytoma; benzene; brain neoplasms; cancer information system; cancer risk; ceramics; chemical carcinogen; chemical carcinogenesis; dust; environment related neoplasm /cancer; eye neoplasms; formaldehyde; herbicides; human mortality; human subject; human tissue; industry; interview; leukemia; lymphoma; medical records; mesothelioma; metals; nasopharyngeal neoplasms; neoplasm /cancer epidemiology; nonwater solvent; occupational disease /disorder; occupational hazard; organic chemicals; pesticides; pollution related respiratory disorder; prostate neoplasms; respiratory neoplasm; stomach neoplasms

The Occupational Studies Section conducts epidemiologic studies to determine the role factors from the workplace play in the origin of cancer. Major areas of focus include pesticides, organic solvents and other widely used chemicals, and organic and inorganic dusts. Projects are underway to clarify the provocative associations between pesticides and certain cancers found in earlier Section studies. Cohort mortality studies of pesticide applicators employed by a national lawn care company and county noxious weed departments have recently been initiated. Results from a case-control study of lymphatic and hematopoietic cancer in Nebraska will be available shortly. Nasopharyngeal cancer was found to be associated with occupational exposure to formaldehyde in a case-control study, resembling findings from a mortality study of industrial workers. A study of embalmers is underway which includes a detailed industrial hygiene monitoring component for formaldehyde and other chemicals to clarify cancer excesses reported in this occupation. The 10-fold excess of astrocytic brain cancer associated with long-term employment in the electronics industry in a case-control study appeared to be more closely related to solvent and other chemical exposures than to electromagnetic radiation. Evaluation of the risk of bladder cancer among persons employed in the chemical industry using data from the National Bladder Cancer Survey found few significant excesses, although men employed for more than 20 years in the production of organic chemicals had a 2.4-fold excess. Major efforts underway include industrial workers exposed to acrylonitrile; grain millers exposed to fumigants; workers in dusty trades exposed to silica; workers in China exposed to benzene; firefighters exposed to combustion products; and furniture workers exposed to wood dusts, metal fumes, and paints, varnishes and solvents. Methodologic studies are being conducted to improve exposure assessment procedures and to develop resources for occupational studies such as a referent data base composed of workers.

职业研究部分将流行病学研究进行 确定工作场所发挥的作用因素 癌症。 重点的主要领域包括农药，有机 溶剂和其他广泛使用的化学品，以及有机和无机 灰尘。 正在进行的项目以阐明挑衅性 农药与某些癌症之间的关联 较早的部分研究。 农药的队列死亡率研究 国家草坪护理公司和县雇用的申请者 最近启动了有害的杂草部门。 结果 从淋巴和造血癌的病例对照研究中 内布拉斯加州将很快上市。 鼻咽癌是 发现与职业接触甲醛有关 在一项病例对照研究中，类似于死亡率研究的发现 工业工人。 正在进行防腐剂的研究 包括一个详细的工业卫生监测组件 甲醛和其他化学物质以阐明癌症过剩 在此职业中报告。 超过10倍星形胶质细胞 与长期就业有关的脑癌 案例对照研究中的电子行业似乎更多 与溶剂和其他化学暴露密切相关，而不是 电磁辐射。 评估膀胱风险 化学工业雇用的人使用数据的癌症 来自国家膀胱癌调查发现很少 过剩，尽管男人在 有机化学品的产生过剩2.4倍。 主要的 正在进行的努力包括接触的工业工人 丙烯腈;暴露于熏蒸剂的谷物磨坊主；尘土飞扬的工人 暴露于二氧化硅的交易；中国的工人暴露于苯； 暴露于燃烧产品的消防员；和家具工人 暴露于木尘，金属烟气和油漆，清漆和 溶剂。 正在进行方法学研究以改善 暴露评估程序并为 职业研究，例如由参考数据库组成 工人。