STUDIES OF OCCUPATIONAL CANCER

职业癌症的研究

• 批准号: 3838307
• 负责人: A E BLAIR
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838307
• 关键词: China; United States; agriculture worker; asbestos; cancer risk; chemical carcinogen; chemical related neoplasm /cancer; colon neoplasms; dust; dyes; environment related neoplasm /cancer; female; human subject; industry; lung neoplasms; male; multiple myeloma; neoplasm /cancer epidemiology; neoplasm /cancer genetics; nonHodgkin's lymphoma; nonwater solvent; occupational disease /disorder; occupational hazard; oral pharyngeal neoplasm; pesticide biological effect; pesticides; silicates; tobacco; work site

The Occupational Studies Section conducts epidemiologic studies to identify and quantify occupational and other causes of cancer. During the past year investigations have uncovered associations between lymphatic and hematopoietic, skin, lip, brain, stomach, and prostate cancer and employment as a farmer. Use of several pesticides including carbaryl, diazinon, dichlorvos, and malathion was linked with non- Hodgkin's lymphoma. Lung cancer was excessive among silicotics previously employed in the dusty trades in North Carolina, but not among workers exposed to silica in China. Multiple myeloma and non-Hodgkin's lymphoma were elevated among workers at an Air Force base with potential exposure to various organic solvents. Risks were particularly high among women. Personal use of hair dyes appeared to increase the risk of non- Hodgkin's lymphoma and multiple myeloma among men and women from Nebraska. Risks were greater among those who used dark, permanent dyes. Associations between certain HLA genotypes and multiple myeloma points to a role for genetic factors into the origin of this tumor. Tobacco was associated with the development of colon polyps and leukemia, but not with multiple myeloma. Currently under investigation include studies of pesticides, benzene, methylene chloride, acrylonitrile, formaldehyde, benzidine asbestos, silica, and methodologic investigations to improve exposure assessments. Occupational groups with complex exposures under study include jewelry manufacturers, laboratory workers, farmers, industrial workers in Turkey, pesticide applicators, and embalmers.

职业研究部分将流行病学研究进行 识别并量化癌症的职业和其他原因。 期间 过去的一年调查发现了 淋巴和造血，皮肤，嘴唇，脑，胃和前列腺 癌症和农民就业。 使用几种农药包括 Carbaryl，Diazinon，Dichlorvos和Malathion与非 - 霍奇金的淋巴瘤。 在硅酸盐中肺癌过多 以前从事北卡罗来纳州的尘土飞扬的行业，但不在 工人在中国接触二氧化硅。 多发性骨髓瘤和非霍奇金的 在潜在的空军基地的工人中，淋巴瘤升高 暴露于各种有机溶剂。 风险在 女性。 个人使用染发剂似乎增加了非 - 霍奇金的淋巴瘤和多发性骨髓瘤 内布拉斯加州。 使用黑暗永久染料的人中的风险更大。 某些HLA基因型与多发性骨髓瘤之间的关联指向 遗传因素进入该肿瘤起源的作用。 烟草是 与结肠息肉和白血病的发展有关，但无关 多发性骨髓瘤。 目前正在研究的研究包括 农药，苯，甲基氯，丙烯腈，甲醛， 苯甲胺石棉，二氧化硅和方法学研究以改善 暴露评估。 具有复杂暴露的职业群体 研究包括珠宝制造商，实验室工人，农民， 土耳其，农药施用者和防腐剂的工业工人。