STUDIES OF OCCUPATIONAL CANCER

职业癌症的研究

• 批准号: 3874597
• 负责人: A E BLAIR
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874597
• 关键词: China; Hodgkin's disease; adenocarcinoma; agriculture worker; benzene; brain neoplasms; cancer information system; cancer risk; ceramics; chemical carcinogen; chemical carcinogenesis; chemical related neoplasm /cancer; chromium; colon neoplasms; cyanides; dust; engine exhaust; environment related neoplasm /cancer; formaldehyde; herbicides; human mortality; human subject; human tissue; industry; interview; leukemia; liver cirrhosis; lung neoplasms; lymphoma; medical records; metals; multiple myeloma; nasopharyngeal neoplasms; neoplasm /cancer epidemiology; nonwater solvent; occupational disease /disorder; occupational hazard; organic chemicals; pancreas neoplasms; pesticides; petroleum oil; pollution related respiratory disorder; prostate neoplasms; radon; resin; respiratory neoplasm; silicates; tobacco abuse; trichloroethylene

The Occupational Studies Section conducts epidemiologic studies to identify the occupational causes of cancer. Major areas of investigation include pesticides, organic solvents and other widely used chemicals, organic and inorganic dusts and methodologic investigations to improve exposure assessments. Studies of agricultural-related occupations uncovered elevated risks for lymphatic and hematopoietic cancer among farmers and flour millers. The excess of non-Hodgkin's lymphoma among farmers was strongly associated with use of the herbicide, 2,4-D. Excesses for certain lymphatic and hematopoietic tumors were also noted among Coast Guard marine inspectors exposed to a variety of chemicals while inspecting ships and barrages, among embalmers and funeral directors exposed to formaldehyde and other chemicals, and among dry cleaners having contact with perchloroethylene and petroleum solvents. Physical activity occurring on the job was associated with a reduced risk of colon cancer in two studies. Lung cancer was excessive among workers in hematite mines exposed to silica and radon, among workers exposed to chrome pigments, among workers engaged in the production of resins and molding compounds, and among persons exposed to motor vehicle exhausts. Major efforts underway include investigations of industrial workers exposed to acrylonitrile; workers in dusty trades exposed to silica; workers in China exposed to benzene; lawn care workers and agricultural applicators exposed to herbicides; embalmers exposed to formaldehyde, occupational and other causes of non-Hodgkin's lymphoma, multiple myeloma, and cancers of the brain, pancreas, and bladder; and workers in Turkey exposed to various industrial chemicals. Methodologic studies are being conducted to improve exposure assessment procedures and to develop a referent data base composed of workers.

职业研究部分进行流行病学研究以识别 癌症的职业原因。调查的主要领域包括 农药，有机溶剂以及其他广泛使用的化学物质，有机和 无机灰尘和方法学研究以改善暴露 评估。与农业相关职业的研究发现了 农民和面粉中淋巴和造血癌的风险 米勒。农民中非霍奇金淋巴瘤的过量强烈 与使用除草剂2,4-D有关。过量某些淋巴 海岸警卫队海军陆战队中还注意到造血肿瘤 检查员在检查船只时暴露于多种化学物质和 在暴露于甲醛的防腐剂和fun仪主管中 其他化学物质，以及与之接触的干洗剂 高氯乙烯和石油溶剂。体育活动发生 这项工作与两项研究中的结肠癌风险降低有关。 暴露于二氧化硅的赤铁矿地雷的工人中肺癌过剩 在接触Chrome颜料的工人中，rad在互动的工人中 在树脂和成型化合物的生产中以及人中 暴露于机动车排气管。正在进行的重大努力包括 暴露于丙烯腈的工业工人的调查；工人进 尘土飞扬的交易暴露于二氧化硅；中国的工人暴露于苯；草地 暴露于除草剂的护理人员和农业施用者；防腐剂 暴露于非霍奇金的甲醛，职业和其他原因 淋巴瘤，多发性骨髓瘤和大脑的癌症，胰腺和 膀胱;土耳其的工人接触了各种工业化学品。 正在进行方法学研究以改善暴露评估 程序并开发由工人组成的参考数据库。