STUDIES OF OCCUPATIONAL CANCER

职业癌症的研究

• 批准号: 3774763
• 负责人: A E BLAIR
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774763
• 关键词: agriculture worker; bladder neoplasm; body physical activity; cancer risk; chemical carcinogen; chemical related neoplasm /cancer; colon neoplasms; dust; dyes; environment related neoplasm /cancer; environmental toxicology; formaldehyde; human subject; industry; lung neoplasms; multiple myeloma; neoplasm /cancer epidemiology; nonHodgkin's lymphoma; nonwater solvent; occupational disease /disorder; occupational hazard; pesticide biological effect; pesticides; tobacco abuse

The Occupational Studies Section conducts epidemiologic studies to identify occupational and other causes of cancer. During the past year, several investigations focused on cancer risks from agricultural exposures. Associations between several insecticides and non-Hodgkin's lymphoma (NHL) were observed among men and women. No clear associations were observed with 2,4-D and atrazine, two widely used herbicides. NHL and multiple myeloma were linked with work in metal, textile, and plastic industries. Diffuse NHL was more strongly associated with exposure to benzene and other solvents than was follicular NHL, which was excessive among workers exposed to oils and greases. Lung cancer was excessive among silicotics previously employed in the dusty trades in North Carolina. Risk of bladder cancer was elevated 150-fold among those heavily exposed to benzidine, but risks among fast and slow acetylator phenotypes were similar. Personal use of hair dyes appeared to increase the risk of NHL and multiple myeloma among men and women from Nebraska. Risks were greater among those who used dark, permanent dyes. Multiple myeloma was also associated with use of hair dyes among men from Iowa. Cigarette smoking was associated with leukemia. Physical activity on the job was inversely associated with cancer of the colon, prostate, and cervix. A computerized job exposure profile was developed to facilitate documentation of quantitative exposure assessments in cohort studies. Currently under investigation include studies of pesticides, benzene, methylene chloride, acrylonitrile, formaldehyde, asbestos, silica, and methodologic investigations to improve exposure assessments. Occupational groups with complex exposures include farmers, industrial workers in Turkey, pesticide applicators, firefighters and embalmers.

职业研究部分将流行病学研究进行 确定癌症的职业和其他原因。 在过去的一年中 几项重点是农业癌症风险的调查 暴露。 几种杀虫剂与非霍奇金之间的关联 在男性和女性中观察到淋巴瘤（NHL）。 没有明确的关联 用2,4-D和阿特拉津观察到两种广泛使用的除草剂。 NHL 多发性骨髓瘤与金属，纺织品和塑料的作品有关 行业。 弥漫性NHL与暴露更加密切相关 苯和其他溶剂，而不是卵泡NHL 在暴露于油和油脂的工人中。 肺癌过多 以前在北部尘土飞扬的硅酸盐中 卡罗来纳州。 在这些风险中，膀胱癌的风险升高了150倍 大量暴露于苯甲胺，但在乙酰基快速和缓慢的乙酰苯甲酸 表型相似。 染发剂的个人使用似乎增加了 内布拉斯加州男性和女人的NHL风险和多发性骨髓瘤的风险。 使用黑暗永久染料的人中的风险更大。 多种的 骨髓瘤也与来自爱荷华州男性的染发剂使用有关。 吸烟与白血病有关。 在 约伯与结肠，前列腺癌和 宫颈。 开发了计算机化的工作曝光概况以促进 队列研究中定量暴露评估的记录。 目前正在研究的研究包括农药的研究，苯， 甲基氯，丙烯腈，甲醛，石棉，二氧化硅和 方法学研究以改善暴露评估。 职业 具有复杂暴露的团体包括农民，工业工人 土耳其，农药施用者，消防员和防腐剂。