STUDIES OF OCCUPATIONAL CANCER

职业癌症的研究

• 批准号: 3939609
• 负责人: A E BLAIR
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939609
• 关键词: Hodgkin's disease; adenocarcinoma; agriculture worker; astrocytoma; benzene; bladder neoplasm; brain neoplasms; cancer information system; cancer risk; ceramics; chemical carcinogen; chemical carcinogenesis; environment related neoplasm /cancer; eye neoplasms; formaldehyde; herbicides; human mortality; human tissue; industry; interview; iron; leukemia; lung neoplasms; lymphoma; medical records; mesothelioma; metals; nasopharyngeal neoplasms; neoplasm /cancer epidemiology; occupational disease /disorder; occupational hazard; pesticides; pollution related respiratory disorder; prostate neoplasms; respiratory neoplasm; stomach neoplasms

The Occupational Studies Section supports and conducts epidemiologic studies of occupational groups to identify and clarify the role factors in the workplace play in the origin of cancer. During the past year several studies were completed on cancer risks among workers exposed to pesticides. A mortality study of farmers from Wisconsin noted excesses of cancers of the lymphatic and hematopoietic system, stomach, prostate and eye. Excess deaths from lymphatic cancer were noted among grain workers, particularly those from grain mills where pesticides are used to control insects. A case-control study in Kansas uncovered a striking dose-response between the risk of non-Hodgkin's lymphoma and number of days of use of herbicides, particularly 2,4-D that rose to over sixfold among farmers with 20 or more days of exposure. A study of industrial workers exposed to formaldehyde uncovered an excess of cancer of the nasopharynx that rose with increasing level of exposure among workers who were also exposed to formaldehyde-containing particulates and a 30% excess of lung cancer that was not associated with level of exposure. Industrial hygiene monitoring for formaldehyde in industry found eight-hour time-weighted averages below 2 ppm in most plants but higher levels occurred in areas where formaldehyde-containing particulates were present. Excesses of leukemia and brain cancer (predominantly gliomas) were seen among anatomists. A case-control study of nasal cancer in the Netherlands found that the will-known excessive risk of adenocarcinoma from exposure to wood dusts (16-fold) did not decrease for at least 15 years after termination of exposure. Annual increases in incidence of mesothelioma between 1973 and 1980 of approximately 12% remained after a histopathologic review by a panel of expert pathologists. A 10-fold excess of astrocytic brain cancer was associated with long-term employment in the electronics industry in a case-control located in Pennsylvania, New Jersey, and Louisiana. Workers producing ceramic plumbing fixtures exposed to talc had over twice the expected mortality from lung cancer.

职业研究部分支持和进行 职业群体的流行病学研究以识别和 阐明工作场所发挥的角色因素的起源 癌症。 在过去的一年中，几项研究完成了 暴露于农药的工人的癌症风险。 死亡率 威斯康星州农民的研究指出了过多的癌症 淋巴和造血系统，胃，前列腺和眼睛。 在谷物中注意到淋巴癌的过量死亡 工人，尤其是那些来自农药的谷物磨坊的工人 用于控制昆虫。 堪萨斯州的一项案件对照研究发现了 非霍奇金风险之间的惊人剂量反应 淋巴瘤和除草剂使用天数，特别是 2,4-D在有20岁或更多的农民中升至超过6倍 暴露天数。 对接触的工业工人的研究 甲醛发现了过量的鼻咽癌 随着工人之间的暴露水平越来越高 也暴露于含甲醛的颗粒和A 30％过量的肺癌与水平无关 接触。 工业卫生监测甲醛 行业发现八个小时的时间加权平均水平低于2 ppm 大多数植物和较高水平都发生在 存在含甲醛的颗粒。 过剩 观察白血病和脑癌（主要是神经胶质瘤） 在解剖学家中。 鼻癌的病例对照研究 荷兰发现，未知的过度风险 暴露于木尘（16倍）的腺癌没有 终止暴露后至少减少15年。 1973年至 组织病理学后，约有12％的1980年仍保留 由专家病理学家小组审查。 超过10倍 星形细胞脑癌与长期有关 电子行业的就业 在宾夕法尼亚州，新泽西州和路易斯安那州。 工人生产 暴露于滑石粉的陶瓷管道固定装置超过两倍 肺癌的预期死亡率。