STUDIES OF OCCUPATIONAL CANCER

职业癌症的研究

• 批准号: 3853390
• 负责人: A E BLAIR
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853390
• 关键词: agriculture worker; asbestos; benzene; cancer risk; chemical carcinogen; chemical related neoplasm /cancer; chromium; cyanides; dust; engine exhaust; environment related neoplasm /cancer; female; formaldehyde; herbicides; human subject; industry; interview; leukemia; lifestyle; lymphoma; multiple myeloma; neoplasm /cancer epidemiology; nonwater solvent; occupational disease /disorder; occupational hazard; oral pharyngeal neoplasm; pesticides; resin; respiratory neoplasm; silicates; trichloroethylene

The Occupational Studies Section conducts a wide-ranging program of epidemiologic studies to identify the occupational causes of cancer. Currently under investigation include studies of pesticides, benzene, methylene chloride, acrylonitrile, formaldehyde, asbestos, silica, phenol, combustion products, and methodologic investigations to improve exposure assessments. Occupational groups with complex exposures include jewelry manufacturers, laboratory workers, farmers, industrial workers in Turkey, pesticide applicators, embalmers, and workers exposed to benzene, acrylonitrile, and benzidine. Studies of agricultural-related occupa- tions uncovered elevated risks for lymphatic and hematopoietic cancer among farmers. Non-Hodgkin's lymphoma among farmers was strongly associated with use of the herbicide, 2,4-D. Leukemia was associated with several insecticides, particularly if used on animals. Leukemia, non-Hodgkin's lymphoma and nasopharyngeal cancer were elevated among embalmers and funeral directors (among blacks as well as whites) exposed to formaldehyde, while multiple myeloma and non-Hodgkin's lymphoma were associated with solvent exposure among aircraft maintenance workers, particularly among women. An excess of lung cancer among industrial workers exposed to formaldehyde occurred primarily in resin-producing plants and appeared to be due to chemicals other than formaldehyde. Lung cancer was also excessive among silicotics previously employed in the dusty trades in North Carolina. Total mortality, cancer and arteriosclerotic heart disease were greater among workers employed less than one year at the plant than among those employed longer, a phenomenon noted in other studies. This mortality difference appears to be due to lifestyle differences because short-term workers were not assigned to jobs with more intense exposures.

职业研究部分进行了一个广泛的计划 流行病学研究以确定癌症的职业原因。 目前正在研究的研究包括农药的研究，苯， 甲基氯，丙烯腈，甲醛，石棉，二氧化硅， 苯酚，燃烧产品和方法研究以改进 暴露评估。 具有复杂暴露的职业群体包括 珠宝制造商，实验室工人，农民，工业工人 土耳其，农药施用者，防腐剂和暴露于苯的工人， 丙烯腈和苯甲胺。 与农业相关的占领的研究 发现淋巴和造血癌的风险升高 在农民中。 农民中非霍奇金的淋巴瘤强烈 与使用除草剂2,4-D有关。 白血病是相关的 有几种杀虫剂，特别是如果用于动物。 白血病， 非霍奇金的淋巴瘤和鼻咽癌升高 防腐剂和fun仪馆（黑人和白人）暴露了 甲醛，而多发性骨髓瘤和非霍奇金的淋巴瘤是 与飞机维护工人之间的溶剂暴露有关， 特别是在女性中。 工业中过量的肺癌过量 暴露于甲醛的工人主要发生在产生树脂 植物，似乎是由于甲醛以外的化学物质。 肺 在以前在以前用过的硅酸盐中，癌症也过量 在北卡罗来纳州进行尘土飞扬的交易。 总死亡率，癌症和 在受雇的工人中，动脉硬化心脏病更大 在工厂的一年比雇用的植物中的一年，这是一种现象 在其他研究中指出。 这种死亡率差异似乎是由于 生活方式差异是因为短期工人未分配 暴露更加强烈的工作。