Comprehensive treatment of heart failure, cardiac hypertrophy, and arrhythmia by controlling ryanodine receptor bound calmodulin

通过控制兰尼碱受体结合钙调蛋白综合治疗心力衰竭、心脏肥大和心律失常

• 批准号: 17H04178
• 负责人: YANO Masafumi
• 金额: $ 10.73万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04178/
• 关键词: リアノジン受容体; カルモジュリン; 心肥大; 心不全; 不整脈; EC coupling

项目成果

Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse

R4496C/敲入小鼠中 RyR2 的通道孔突变导致钙渗漏，与 FKBP12.6-RyR2 和钙调蛋白-RyR2 亲和力无关

• 发表时间: 2017
• 作者: Hitoshi Uchinoumi;Ivanita Stefanon;Yi Yang;Mena Said;Xiaoqiong Dong;Rogerio Faustino;Jose L Puglisi;Ye Chen-Izu;Razvan L Cornea;Xander H Wehrens;Wayne S Chen;Takeshi Yamamoto;Yano Masafumi and Donald M Bers
• 通讯作者: Yano Masafumi and Donald M Bers

G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model

• DOI: 10.1016/j.bbrep.2019.100711
• 发表时间: 2019-11
• 期刊: Biochemistry and Biophysics Reports
• 影响因子: 2.7
• 作者: Y. Hamada;Takeshi Yamamoto;Y. Nakamura;Yoko Sufu-Shimizu;Takuma Nanno;Masakazu Fukuda;M. Ono;T. Oda;S. Okuda;T. Ueyama;Shigeki Kobayashi;M. Yano

Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.

钙调蛋白结合域和心脏兰尼碱受体 C 端域之间突变相关的过度紧密相互作用是儿茶酚胺能多形性室性心动过速的新原因。

• DOI: 10.1016/j.hrthm.2018.02.006
• 发表时间: 2018
• 期刊: Heart Rhythm
• 影响因子: 5.5
• 作者: Nishimura S;Yamamoto T;Nakamura Y;Kohno M;Hamada Y;Sufu Y;Fukui G;Nanno T;Ishiguchi H;Kato T;Xu X;Ono M;Oda T;Okuda S;Kobayashi S;Yano M.
• 通讯作者: Yano M.

Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression

Dantrolene 对 Camkii 磷酸化 Ryr2 的稳定可预防由 CamkiiδC 过度表达引起的年龄相关性心肌病的发展

• 发表时间: 2017
• 作者: Yoko S Shimizu;Shinichi Okuda;Yoko Okamoto;Shigehiko Nishimura;Takayoshi Kato;Tetsuro Oda;Shigeki Kobayashi;Takeshi Yamamoto and Masafumi Yano
• 通讯作者: Takeshi Yamamoto and Masafumi Yano

The Difference of Calmodulin-Ryanodine Receptor Affinity Between N-terminal, Central and C-terminal RyR2-CPVT Knock-in Mice

N端、中央端和C端RyR2-CPVT敲入小鼠钙调蛋白-兰尼定受体亲和力的差异

• 发表时间: 2019
• 作者: Hitoshi Uchinoumi;Xiaoqiong Dong;Ivanita Stefanon;Mena Said;Rogerio Faustino;Razvan L Cornea;Univ of Minnesota;Xander H.t. Wehrens; Takeshi Yamamoto;Masafumi Yano;Donald M Bers
• 通讯作者: Donald M Bers