Development of novel molecular targeted therapy by stabilizing cardiac ryanodine receptors in hypertrophic cardiomyopathy

通过稳定心脏兰尼碱受体开发新型分子靶向治疗肥厚型心肌病

• 批准号: 18K08076
• 负责人: OKUDA Shinichi
• 金额: $ 2.91万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K08076/
• 关键词: 肥大型心筋症; リアノジン受容体; カルシウム依存性カルモジュリンキナーゼ; カルモジュリン; カルモジュリン依存性プロテインキナーゼII

项目成果

Dantrolene Prevents the Development of Age-Related Cardiomyopathy by Stabilization of CaMKII-Phosphorylated RyR2 in CaMKIIδC Transgenic Mice

丹曲林通过稳定 CaMKIIδC 转基因小鼠中的 CaMKII 磷酸化 RyR2 来预防年龄相关性心肌病的发生

• 发表时间: 2018
• 作者: Yoko Sufu-Shimizu; Shinichi Okuda; Yoko Okamoto; Shigehiko Nishimura; Takayoshi Kato;Tetsuro Oda; Shigeki Kobayashi; Takeshi Yamamoto;and Masafumi Yano
• 通讯作者: and Masafumi Yano

G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model

• DOI: 10.1016/j.bbrep.2019.100711
• 发表时间: 2019-11
• 期刊: Biochemistry and Biophysics Reports
• 影响因子: 2.7
• 作者: Y. Hamada;Takeshi Yamamoto;Y. Nakamura;Yoko Sufu-Shimizu;Takuma Nanno;Masakazu Fukuda;M. Ono;T. Oda;S. Okuda;T. Ueyama;Shigeki Kobayashi;M. Yano

Stabilization of CaMKII-phosphorylated RyR2 Mediated through P harmacological Enhancement of Calmodulin Binding to RyR2 Prevents the Development of Cardiac Dysfunction

通过药理学增强钙调蛋白与 RyR2 结合介导的 CaMKII 磷酸化 RyR2 的稳定性可预防心脏功能障碍的发生

• 发表时间: 2020
• 作者: Yoko Sufu-Shimizu ;Shinichi Okuda ;Yoko Okamoto ;Takayoshi Kato ;Hitoshi Uchinoumi ;Tetsuro Oda ;Shigeki Kobayashi ;Takeshi Yamamoto ;Masafumi Yano
• 通讯作者: Masafumi Yano

Stabilization of CaMKII-phosphorylated RyR2 prevents the development of age-related cardiomyopathy caused by transgenic CaMKIIδc overexpression

CaMKII 磷酸化 RyR2 的稳定可预防转基因 CaMKIIδc 过表达引起的年龄相关性心肌病

• 发表时间: 2018
• 作者: Yoko Sufu-Shimizu; Shinichi Okuda; Yoko Okamoto; Shigehiko Nishimura; Takayoshi Kato;Tetsuro Oda; Shigeki Kobayashi; Takeshi Yamamoto;and Masafumi Yano
• 通讯作者: and Masafumi Yano

Addition of a β1-Blocker to Milrinone Treatment Improves Cardiac Function in Patients with Acute Heart Failure and Rapid Atrial Fibrillation

• DOI: 10.1159/000499400
• 发表时间: 2019-01-01
• 期刊: CARDIOLOGY
• 影响因子: 1.9
• 作者: Kobayashi, Shigeki;Myoren, Takeki;Yano, Masafumi
• 通讯作者: Yano, Masafumi