An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control

通过心肌细胞内钙调蛋白控制来逆转心脏肥大的尝试

• 批准号: 16K15443
• 负责人: YANO Masafumi
• 金额: $ 2.25万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K15443/
• 关键词: リアノジン受容体; カルモジュリン; 心肥大; EC coupling; 心不全; 不整脈

项目成果

Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse

R4496C/敲入小鼠中 RyR2 的通道孔突变导致钙渗漏，与 FKBP12.6-RyR2 和钙调蛋白-RyR2 亲和力无关

• 发表时间: 2017
• 作者: Hitoshi Uchinoumi;Ivanita Stefanon;Yi Yang;Mena Said;Xiaoqiong Dong;Rogerio Faustino;Jose L Puglisi;Ye Chen-Izu;Razvan L Cornea;Xander H Wehrens;Wayne S Chen;Takeshi Yamamoto;Yano Masafumi and Donald M Bers
• 通讯作者: Yano Masafumi and Donald M Bers

Nuclear Translocation of Calmodulin, Which Dissociated From Cardiac Ryanodine Receptor, Promotes the Pathological Cardiac Hypertrophy

从心脏兰尼丁受体解离的钙调蛋白的核转位促进病理性心脏肥大

• 发表时间: 2016
• 作者: Tetsuro Oda;Takeshi Yamamoto;Takayoshi Kato;Shigehiko Nishimura;Go Fukui;Shinichi Okuda;Shigeki Kobayashi;Donald Bers and Masafumi Yano
• 通讯作者: Donald Bers and Masafumi Yano

Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression

Dantrolene 对 Camkii 磷酸化 Ryr2 的稳定可预防由 CamkiiδC 过度表达引起的年龄相关性心肌病的发展

• 发表时间: 2017
• 作者: Yoko S Shimizu;Shinichi Okuda;Yoko Okamoto;Shigehiko Nishimura;Takayoshi Kato;Tetsuro Oda;Shigeki Kobayashi;Takeshi Yamamoto and Masafumi Yano
• 通讯作者: Takeshi Yamamoto and Masafumi Yano

Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.

钙调蛋白结合域和心脏兰尼碱受体 C 端域之间突变相关的过度紧密相互作用是儿茶酚胺能多形性室性心动过速的新原因。

• DOI: 10.1016/j.hrthm.2018.02.006
• 发表时间: 2018
• 期刊: Heart Rhythm
• 影响因子: 5.5
• 作者: Nishimura S;Yamamoto T;Nakamura Y;Kohno M;Hamada Y;Sufu Y;Fukui G;Nanno T;Ishiguchi H;Kato T;Xu X;Ono M;Oda T;Okuda S;Kobayashi S;Yano M.
• 通讯作者: Yano M.

Correction of the Defective Channel Gating of Cardiac Ryanodine Receptor Improves Cardiac Function and Suppresses Ventricular Arrhythmia in Post Myocardial Infarction Heart Failure

纠正心脏兰尼丁受体通道门控缺陷可改善心肌梗死后心力衰竭的心功能并抑制室性心律失常

• 发表时间: 2016
• 作者: Hironori Ishiguchi;Shigeki Kobayashi;Michiaki Kohno;Takuma Nanno;Gou Fukui;Yoko Sufu-Shimizu;Yoriomi Hamada;Takako Maeda;Shigehiko Nishimura;Tetsuro Oda;Shinnichi Okuda;Takeshi Ueyama;Takeshi Yamamoto;Masafumi Yano
• 通讯作者: Masafumi Yano