Development of comprehensive treatment of heart failure, hypertrophy, and arrhythmia by regulating intracellular Ca

调节细胞内Ca综合治疗心力衰竭、肥厚、心律失常的进展

• 批准号: 23390215
• 负责人: YANO Masafumi
• 金额: $ 12.31万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390215/
• 关键词: 心不全; 筋小胞体; カルシウム; リアノジン受容体; EC-coupling; Ryanodine receptor; Calmodulin; CPVT

In this three years, we revealed that basic mechanism of arrhythmogenesity in CPVT and pressure overload HF is Ca leak from SR. The underlying mechanism of Ca leak is unzipping of channel reguratory domains and CaM binding domain. We also investigate the dantrolene, zipper of the channel reguratory domains and high affinity CaM as a therapeutic agents.

在这三年中，我们揭示了CPVT中心律失常的基本机制和压力超负荷HF是SR的CA泄漏。 CA泄漏的基本机制是解开通道回流域和CAM结合域的拉链。我们还研究了作为治疗剂的通道回流域的拉链和高亲和力凸轮的拉链。

项目成果

New Data on Catecholaminergic Polymorphic Ventricular Tachycardia in Japan

日本儿茶酚胺能多形性室性心动过速的新数据

• DOI: 10.1253/circj.cj-13-0623
• 发表时间: 2013
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: Shinichi Okuda;Masafumi Yano
• 通讯作者: Masafumi Yano

Novel Selective EP4 Receptor Agonists Restore the Intracellular Ca2+ Handling and the Cardiomyocyte Function in Heart Failure

新型选择性 EP4 受体激动剂可恢复心力衰竭时的细胞内 Ca2 处理和心肌细胞功能

• 发表时间: 2013
• 作者: Wakako Murakami;Shigeki Kobayashi;Takeki Myoren;Shigehiko Nishimura;Takayoshi Katoh;Masakazu Fukuda;Shinichi Okuda;Tetsuro Oda;Takeshi Yamamoto;Masafumi Yano
• 通讯作者: Masafumi Yano

Does a ripple of Ca(2+) leak develop into a rogue wave that can trigger pathological hypertrophy?

• DOI: 10.1016/j.jacc.2013.10.064
• 发表时间: 2014-04
• 期刊: Journal of the American College of Cardiology
• 影响因子: 24
• 作者: M. Yano;S. Okuda

Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Marker of Left Ventricular Remodelling in Patients With Dilated Cardiomyopathy

尿 8-羟基-2-脱氧鸟苷作为扩张型心肌病患者左心室重构的新标志物

• 发表时间: 2012
• 作者: Wakako Murakami;Shigeki Kobayashi;Takamasa Oda;Hiroki Tateishi;Tomoko Nao;Jutaro Yamada;Takayuki Okamura;Masafumi Yano;Masunori Matsuzaki
• 通讯作者: Masunori Matsuzaki

Dantrolene may Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release within Ryanodine Receptor in Cardiac Troponin T-related Hypertrophic Cardiomyopathy

丹曲林可能通过抑制心肌肌钙蛋白 T 相关肥厚性心肌病中瑞尼定受体内 CaMKII 介导的异常 Ca2 释放来抑制心律失常发生

• 发表时间: 2014
• 作者: Shinichi Okuda;Masakazu Fukuda;Takayoshi Katoh;Shigehiko Nishimura;Shigeki Kobayashi;Takeshi Yamamoto;Masafumi Yano
• 通讯作者: Masafumi Yano