New molecular targeting therapy for regression of cardiac hypertrophy by inhibiting abnormal Ca2+ leak through RyR2 in hypertrophic cardiomyopathy

通过 RyR2 抑制异常 Ca2 渗漏来消退肥厚型心肌病的新型分子靶向治疗

• 批准号: 26670404
• 负责人: YANO Masafumi
• 金额: $ 2.33万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26670404/
• 关键词: 肥大型心筋症; リアノジン受容体; カルシウムリーク; カルシウムハンドリング

项目成果

RyR2 stabilization by inhibiting aberrant Ca2+ release mediated by CaMKII signaling and Ca2+ buffering function suppresses arrhythmogenesis in Troponin T-related familial hypertrophic cardiomyopathy

RyR2 通过抑制 CaMKII 信号传导和 Ca2 缓冲功能介导的异常 Ca2 释放来稳定，从而抑制肌钙蛋白 T 相关家族性肥厚型心肌病的心律失常发生

• 发表时间: 2015
• 作者: Okuda S;Kato T;Fukuda M;Nichimura S;Kobayashi S;Oda T;Yamamoto T;Yano M
• 通讯作者: Yano M

Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes

• DOI: 10.1016/j.bbrc.2014.03.152
• 发表时间: 2014-05-23
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Fukuda, Masakazu;Yamamoto, Takeshi;Yano, Masafumi
• 通讯作者: Yano, Masafumi

High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation is Located at CaM-like Domain of RyR2.

高亲和力CaM而非普通亲和力CaM可以预防CPVT中的心律失常，其突变位于RyR2的CaM样结构域。

• 发表时间: 2015
• 作者: Nishimura S;Yamamoto T;Fukui G;Maeda T;Hino A;Suetomi T;Ono M;Mochozuki M;Oda T;Okuda S;Kobayashi S;Yano M
• 通讯作者: Yano M

Comparison of neointimal coverage and extra-stent lumen between sirolimus and everolimus-eluting stent using optical coherence tomography.

使用光学相干断层扫描比较西罗莫司和依维莫司洗脱支架的新内膜覆盖率和支架外管腔。

• DOI: 10.1007/s00380-015-0630-z
• 发表时间: 2015
• 期刊: Heart Vessels
• 影响因子: 1.5
• 作者: Oda T;Okamura T;Yamada J;Miyagi N;Uehara H;Nao T;Tateishi H;Maeda T;Nakamura T;Shiraishi K;Nakashima T;Nishimura S;Miura T;Matsuzaki M;Yano M
• 通讯作者: Yano M

Inhibition of aberrant Ca2+ release through RyR2 mediated by CaMKII and Ca2+ buffering suppresses arrhythmogenesis in troponin T-related hypertrophic cardiomyopathy

CaMKII 和 Ca2 缓冲介导的 RyR2 抑制异常 Ca2 释放可抑制肌钙蛋白 T 相关肥厚型心肌病的心律失常发生

• 发表时间: 2016
• 作者: Okuda S;Kato T;Sufu Y;Fukuda M;Nichimura S;Kobayashi S;Oda T;Yamamoto T;Yano M
• 通讯作者: Yano M