Novel treatment of arrhythmia and heart failure by controlling the domain of ryanodine receptors

通过控制兰尼碱受体结构域治疗心律失常和心力衰竭

基本信息

  • 批准号:
    18K08108
  • 负责人:
  • 金额:
    $ 2.75万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2018
  • 资助国家:
    日本
  • 起止时间:
    2018-04-01 至 2021-03-31
  • 项目状态:
    已结题

项目摘要

项目成果

期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model
  • DOI:
    10.1016/j.bbrep.2019.100711
  • 发表时间:
    2019-11
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Y. Hamada;Takeshi Yamamoto;Y. Nakamura;Yoko Sufu-Shimizu;Takuma Nanno;Masakazu Fukuda;M. Ono;T. Oda;S. Okuda;T. Ueyama;Shigeki Kobayashi;M. Yano
  • 通讯作者:
    Y. Hamada;Takeshi Yamamoto;Y. Nakamura;Yoko Sufu-Shimizu;Takuma Nanno;Masakazu Fukuda;M. Ono;T. Oda;S. Okuda;T. Ueyama;Shigeki Kobayashi;M. Yano
The Difference of Calmodulin-Ryanodine Receptor Affinity Between N-terminal, Central and C-terminal RyR2-CPVT Knock-in Mice
N端、中央端和C端RyR2-CPVT敲入小鼠钙调蛋白-兰尼定受体亲和力的差异
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hitoshi Uchinoumi;Xiaoqiong Dong;Ivanita Stefanon;Mena Said;Rogerio Faustino;Razvan L Cornea;Univ of Minnesota;Xander H.t. Wehrens; Takeshi Yamamoto;Masafumi Yano;Donald M Bers
  • 通讯作者:
    Donald M Bers
Cytokine Adsorption to Polymyxin B-Immobilized Fiber: An in vitro Study
  • DOI:
    10.1159/000510290
  • 发表时间:
    2021-02-01
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Utsunomiya, Toshiaki;Mimura-Kimura, Yuka;Mimura, Yusuke
  • 通讯作者:
    Mimura, Yusuke
Critical Role of Ryanodine Receptor Bound Calmodulin to Prevent Catecholaminergic Polymorphic Ventricular Tachycardia
兰尼定受体结合钙调蛋白在预防儿茶酚胺能多形性室性心动过速中的关键作用
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yoshihide Nakamura;Takeshi Yamamoto;Shigeki Kobayashi;Masaki Tamitani;Yoriomi Hamada;Go Fukui;Xiaojuan Xu;Shigehiko Nishimura;Takayoshi Kato;Hitoshi Uchinoumi;Tetsuro Oda;Shinichi Okuda;Masafumi Yano
  • 通讯作者:
    Masafumi Yano
Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts
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Yamamoto Takeshi其他文献

A study on word-final vowel reduction in American English
美式英语词尾元音缩减研究
Effects of glycemic control on in-hospital mortality among acute heart failure patients with reduced, mid-range, and preserved ejection fraction
血糖控制对射血分数降低、中等和保留的急性心力衰竭患者院内死亡率的影响
  • DOI:
    10.1007/s00380-018-1152-2
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    1.5
  • 作者:
    Matsushita Kenichi;Harada Kazumasa;Miyazaki Tetsuro;Miyamoto Takamichi;Iida Kiyoshi;Tanimoto Shuzou;Yagawa Mayuko;Takei Makoto;Nagatomo Yuji;Hosoda Toru;Yoshino Hideaki;Yamamoto Takeshi;Nagao Ken;Takayama Morimasa
  • 通讯作者:
    Takayama Morimasa
RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure
RyR2 靶向治疗可预防梗死后心力衰竭中的左心室重构和室性心动过速
  • DOI:
    10.1016/j.yjmcc.2023.03.007
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Fujii Shohei;Kobayashi Shigeki;Chang Yaowei;Nawata Junya;Yoshitomi Ryosuke;Tanaka Shinji;Kohno Michiaki;Nakamura Yoshihide;Ishiguchi Hironori;Suetomi Takeshi;Uchinoumi Hitoshi;Oda Tetsuro;Okuda Shinichi;Okamura Takayuki;Yamamoto Takeshi;Yano Masafumi
  • 通讯作者:
    Yano Masafumi
Postprandial glucose and triglyceride metabolism govern premature aging and rejuvenation of bone marrow
餐后葡萄糖和甘油三酯代谢控制过早衰老和骨髓再生
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kajii Toshiro;Kobayashi Shigeki;Shiba Sho;Fujii Shohei;Tamitani Masaki;Kohno Michiaki;Nakamura Yoshihide;Nanno Takuma;Kato Takayoshi;Okuda Shinichi;Uchinoumi Hitoshi;Oda Tetsuro;Yamamoto Takeshi;Yano Masafumi;岩崎真佳
  • 通讯作者:
    岩崎真佳
ミトコンドリア病の分子病態の理解と応用
线粒体疾病分子发病机制的认识与应用
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Asano Kana;Suzuki Takeo;Saito Ayaka;Wei Fan-Yan;Ikeuchi Yoshiho;Numata Tomoyuki;Tanaka Ryou;Yamane Yoshihisa;Yamamoto Takeshi;Goto Takanobu;Kishita Yoshihito;Murayama Kei;Ohtake Akira;Okazaki Yasushi;Tomizawa Kazuhito;Sakaguchi Yuriko;Suzuki Tsutomu;魏范研
  • 通讯作者:
    魏范研

Yamamoto Takeshi的其他文献

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{{ truncateString('Yamamoto Takeshi', 18)}}的其他基金

Unraveling the cooperative action of p53 and autophagy against kidney aging
揭示p53和自噬对抗肾脏衰老的协同作用
  • 批准号:
    21K16163
  • 财政年份:
    2021
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Development of hypernuclear identification method for study of charge symmetry breaking via hypernuclear gamma-ray spectroscopy
通过超核伽马射线谱研究电荷对称性破缺的超核识别方法的发展
  • 批准号:
    19K14744
  • 财政年份:
    2019
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
A study on effect of surface roughness for friction force and surface damage under squeeze motion
挤压运动下表面粗糙度对摩擦力和表面损伤的影响研究
  • 批准号:
    19K04155
  • 财政年份:
    2019
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Induction of tolerance by concomitant use of kakkonto with oral immunotherapy and exploration of candidate blood marker that enable evaluation of the effects of treatments for food allergy
通过同时使用 kakkonto 和口服免疫疗法诱导耐受,并探索候选血液标记物,从而能够评估食物过敏治疗的效果
  • 批准号:
    19K07908
  • 财政年份:
    2019
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Dynamic Induction of Single-Handed Helix by Chiral Guests to Macromolecular Chiral Catalysts with Amplification of Homochirality
手性客体对单手螺旋的动态诱导对大分子手性催化剂的同手性放大
  • 批准号:
    18K14216
  • 财政年份:
    2018
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
mplementing interprofessional education at higher educational institutions in Japan
在日本的高等教育机构实施跨专业教育
  • 批准号:
    17K08920
  • 财政年份:
    2017
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Elucidation of the translocation mechanism of M. pneumoniae across the human bronchial epithelial barrier.
阐明肺炎支原体穿过人支气管上皮屏障的易位机制。
  • 批准号:
    16K19619
  • 财政年份:
    2016
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Establishment of highly effective therapy for food allergy by concomitant use of kakkonto with oral immunotherapy
通过联合使用 kakkonto 和口服免疫疗法,建立食物过敏的高效治疗方法
  • 批准号:
    16K09234
  • 财政年份:
    2016
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Strategies aimed at modulating autophagy for treating kidney diseases
旨在调节自噬治疗肾脏疾病的策略
  • 批准号:
    15H06371
  • 财政年份:
    2015
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
Asymmetric Synthesis of Dibenzohelicenes via Nickel-Catalyzed Intramolecular Cyclization of Triynes Using Helically Chiral Polymer Ligands
使用螺旋手性聚合物配体通过镍催化三炔分子内环化不对称合成二苯并螺旋烯
  • 批准号:
    15K05499
  • 财政年份:
    2015
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

カルモジュリンの核内移行制御による新しい心不全・心肥大の治療
通过控制钙调蛋白核转位治疗心力衰竭和心脏肥大的新方法
  • 批准号:
    21K08054
  • 财政年份:
    2021
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of novel molecular targeted therapy by stabilizing cardiac ryanodine receptors in hypertrophic cardiomyopathy
通过稳定心脏兰尼碱受体开发新型分子靶向治疗肥厚型心肌病
  • 批准号:
    18K08076
  • 财政年份:
    2018
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Elucidation of mechanisms of myocardial ischemia/reperfusion injury mediated through transient receptor potential canonical (TRPC) channels, and establishment of new therapeutics for its treatment.
阐明通过瞬时受体电位经典(TRPC)通道介导的心肌缺血/再灌注损伤的机制,并建立新的治疗方法。
  • 批准号:
    17K08536
  • 财政年份:
    2017
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Comprehensive treatment of heart failure, cardiac hypertrophy, and arrhythmia by controlling ryanodine receptor bound calmodulin
通过控制兰尼碱受体结合钙调蛋白综合治疗心力衰竭、心脏肥大和心律失常
  • 批准号:
    17H04178
  • 财政年份:
    2017
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control
通过心肌细胞内钙调蛋白控制来逆转心脏肥大的尝试
  • 批准号:
    16K15443
  • 财政年份:
    2016
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
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