I-Corps: Wearable Transdermal Vapor Sensors for Non-invasive Continuous Disease Monitoring

I-Corps：用于无创连续疾病监测的可穿戴式透皮蒸汽传感器

• 批准号: 1443335
• 负责人: Xudong Fan
• 金额: $ 5万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1443335&HistoricalAwards=false
• 关键词: Corps; Wearable; Transdermal; Vapor; Sensors

Many diseases (acute and chronic) and human physiological conditions (such as blood alcohol, oxygen, and glucose) need to be monitored continuously for timely clinical intervention and personalized treatment. However, conventional blood-based detection is invasive and prone to infection, and thus cannot be used for continuous monitoring. Recently, it has been found that many vapors from exhaled breath or transpiring from the skin reflect the conditions of various diseases (such as diabetes, peripheral artery disease, etc.). Therefore, wearable vapor sensors provide a completely non-invasive and continuous monitoring solution that tremendously benefits the patients and the society.This I-Corps team has recently demonstrated novel graphene vapor sensor arrays that can be completely embedded in a micro-gas chromatography column for rapid (0.1 s) and sensitive (~ppb) vapor detection. A wearable, badge-sized micro-gas chromatography column system can thus be made to collect and analyze vapors transpiring from the skin with on-chip data processing and transmission capability. The proposed project will be focused on the effort to commercialize the wearable micro-gas chromatography column technology. The team has designed and fabricated such columns that can be integrated with graphene sensor arrays seamlessly. The team has also tested the graphene sensor's response time and sensitivity and showed a detection speed over 100 times faster than the state-of-the-art.

许多疾病（急性和慢性）以及人类生理状况（例如血液酒精，氧气和葡萄糖）需要连续监测以及时临床干预和个性化治疗。但是，常规的基于血液的检测是侵入性的，容易感染，因此不能用于连续监测。最近，已经发现，从呼气的呼吸或皮肤蒸发中的许多蒸气反映了各种疾病的状况（例如糖尿病，周围动脉疾病等）。因此，可穿戴的蒸气传感器提供了一种完全无创和连续的监测解决方案，可极大地使患者和社会受益。该I-Corps团队最近证明了新型的石墨烯蒸汽传感器阵列，可以将其完全嵌入微型Gas色谱柱中，以用于快速（0.1 s）和敏感（0.1 s）和敏感（〜ppb）Vapor vapor检测。因此，可以制作可穿戴的，徽章大小的微气相色谱柱系统，以通过芯片数据处理和传输能力收集和分析从皮肤中蒸发的蒸气。拟议的项目将集中于将可穿戴的微气相色谱柱技术商业化的努力。 该团队设计和制造了可以与石墨烯传感器阵列集成的这些列。该团队还测试了石墨烯传感器的响应时间和敏感性，并显示出比最先进的速度快100倍的检测速度。