Plasmonically enhanced optical ring resonators for label-free single molecule detection

用于无标记单分子检测的等离子增强光学环形谐振器

• 批准号: 1303499
• 负责人: Xudong Fan
• 金额: $ 20万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1303499&HistoricalAwards=false
• 关键词: Plasmonically; enhanced; optical; ring; resonators

The objective of the proposed collaborative research is to develop a plasmonically enhanced opticalring resonator (PEORR) sensor array for unlabelled biomolecule detection at the single molecule level.The proposed hybrid sensor synergizes microfabricated ring resonators and nanofabricated plasmonicnanostructures. It takes advantage of the excellent sensing resolution associated with the ring resonatorand the tremendously enhanced sensitivity arising from the plasmonic nanostructures to achieve singlemolecule detection, and of the carousel effect from the ring resonator for efficient capture and transport ofbiomolecules for sample enrichment and expeditious detection. Intellectual Merit: Detection and study of biomolecules at the single molecule level allow to probe andcharacterize molecules in unprecedented detail. Traditional single molecule detection relies primarily onfluorescence microscopy, which requires sophisticated instruments and complicated dye labelingprocesses that may adversely affect a molecules functionality. Broader Impact: The proposed project will be carried out synergistically by the terms from the Universityof Michigan and the Polytechnic Institute at New York University. Graduate students will betrained in interdisciplinary science and will work in each of the two labs through an exchange program.Undergraduate students will be paired with graduate students to obtain hands-on experience. Videos onYoutube will be jointly created to publicize the research findings. Finally, the PI will work with local non-Ph.D. granting colleges to develop a summer program for their students to conduct research in the PI'slab at the University of Michigan.

拟议的合作研究的目的是开发单个分子水平上未标记的生物分子检测的血浆增强的光学谐振器（PEORR）传感器阵列。拟议的混合传感器对微生物的环形谐振器和纳米制动的静脉曲张nanosonostrupers进行了造型混合动力传感器。它利用了与环谐振器相关的出色传感分辨率，并利用了血浆纳米结构产生的极大增强的灵敏度，以实现单分子检测，以及环谐振器的旋转旋转频率，以有效地捕获和运输样品富集和快速检测。智力优点：对单分子水平的生物分子的检测和研究，可以以前所未有的细节探测和表征分子。传统的单分子检测主要依赖于洋流显微镜，该显微镜需要复杂的仪器和复杂的染料标记程序，可能会对分子功能产生不利影响。更广泛的影响：拟议的项目将由密歇根大学和纽约大学理工学院的条款协同实施。研究生将属于跨学科科学，并通过交流计划在两个实验室中的每个实验室中工作。视频Onyoutube将共同创建以宣传研究结果。最后，PI将与本地非PH.D一起使用。授予大学为学生开发一个夏季课程，以在密歇根大学的Pi'Slab进行研究。