Advancing Photoacoustic Tomography in breast imaging to predict response in breast cancers treated with neoadjuvant therapy

推进乳腺成像中的光声断层扫描以预测新辅助治疗乳腺癌的反应

• 批准号: 10715163
• 负责人: LILY LAU LAI
• 金额: $ 64.36万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-03 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10715163
• 关键词: 3-Dimensional; Acoustics; Address; Algorithms; Anatomy; Anxiety; Arteries; Biopsy; Blood Vessels; Brain; Brain imaging; Breast; Breast Cancer Detection; Breast Cancer Patient; Breast Cancer Treatment; Breast Cancer therapy; Breast conservation; Calibration; Cancer Burden; Cities; Clinical; Contrast Media; Data; Detection; Diagnostic; Dimensions; Discrimination; Elasticity; Emerging Technologies; Engineering; Evaluation; Feasibility Studies; Frequencies; Functional Imaging; Heavy Metals; Hemoglobin; Human; Image; Imaging Techniques; Imaging problem; Imaging technology; Intravenous; Ionizing radiation; Light; Lilium; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Metabolic; Methods; Modeling; Morphologic artifacts; Morphology; Motion; Neoadjuvant Therapy; Operative Surgical Procedures; Optics; Outcome; Oxygen; Pathology; Patients; Performance; Physicians; Prognosis; Resected; Resolution; Resources; Sampling; Scientist; Side; Signal Transduction; Specimen; Speed; Surgical Pathology; System; Technology; Testing; Three-Dimensional Imaging; Time; Tissues; Training; Tumor Volume; Ultrasonography; X-Ray Computed Tomography; anatomic imaging; breast imaging; contrast enhanced; cost; cost effective; density; design; diffuse optical spectroscopy and imaging; exceptional responders; experience; imaging modality; imaging system; improved; improved outcome; innovation; malignant breast neoplasm; model building; new technology; non-invasive imaging; optoacoustic tomography; patient oriented; performance tests; personalized cancer therapy; photoacoustic imaging; precision medicine; predicting response; prognostic; prospective; prototype; research clinical testing; respiratory; response; standard of care; success; tomography; treatment planning; treatment response; tumor

PROJECT SUMMARY/ABSTRACT Objective: We will develop an advanced photoacoustic computed tomography (PACT) breast imaging system capable of detecting anatomical and functional changes in breast cancer treated with neoadjuvant therapy (NAT). Significance: NAT improves outcomes in breast cancer patients by increasing the likelihood of breast conservation, providing important prognostic information, and enabling adaptive therapy such as change in systemic treatment and de-escalation of surgery in exceptional responders. As such, identification of responders enables personalized cancer treatment. Challenges: Current breast imaging does not sufficiently detect breast cancer treatment response. Standard of care (SOC) breast imaging technology either assesses anatomical details or metabolic function, not both. In addition, ionizing radiation, exogenous contrast agents, and patient perceived discomfort and inconvenience usually restrict imaging frequency required for timely evaluation of response. For example, although dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is considered the SOC in breast imaging, this test is limited by the need for intravenous heavy metal contrast, duration of study, patient discomfort, and high resource costs while delivering only moderate accuracy in detection of NAT response. As such, there is no reliable,non-invasive, cost-effective imaging method to identify treatment response.PACT is an emerging technology with great potential to address these problems by imaging both function and anatomy without exogenous contrast. Solutions: Capitalizing on our experience and success in building two PACT breast imaging systems, we propose the construction and clinical testing of an innovative PACT imaging system that integrates the two previous systems to enable both anatomical and functional imaging. The Dual Mode PACT (DM-PACT) will combine dual-sided light delivery, large-view detection aperture, and dense acoustic sampling for rapid functional and high-resolution anatomical imaging to assess treatment-related responses in breast cancer. The imaging features generated by the DM-PACT will be first characterized and correlated with the histopathological results of the resected breast cancer specimens from patients treated with NAT. A diagnostic model using the imaging features will be trained and tested in a larger group of breast cancer patients treated with NAT. We will compare the performance of DM-PACT with the performance of SOC DCE-MRI in treatment response discrimination. The success of this project will result in imaging technology that directs response- driven, personalized breast cancer treatment plans.

项目摘要/摘要 目的：我们将开发高级光声计算机断层扫描（PACT）乳房成像系统 能够检测新辅助治疗治疗的乳腺癌的解剖和功能变化 （nat）。 意义：NAT通过增加乳房的可能性来改善乳腺癌患者的结局 保护，提供重要的预后信息，并实现适应性疗法，例如改变 特殊响应者中的全身治疗和降级手术。因此，识别 响应者可以实现个性化的癌症治疗。 挑战：当前的乳房成像不能充分检测到乳腺癌的治疗反应。标准 护理（SOC）乳房成像技术要么评估解剖学细节或代谢功能，而不是两者兼而有之。在 另外，电离辐射，外源对比剂以及患者认为不适和不便 通常限制及时评估响应所需的成像频率。例如，虽然动态 对比增强的磁共振成像（DCE-MRI）被认为是乳房成像中的SOC，该测试 受静脉注重金属对比，研究持续时间，患者不适和高度的需要的限制 资源成本在仅提供适度的NAT响应中准确性的同时。这样，那里 是 不 可靠的，无创的，具有成本效益的成像方法来识别治疗反应。 通过对功能和解剖结构进行成像而无需成像，具有很大潜力的技术 外源对比度。 解决方案：利用我们的经验和成功建立两个协议乳房成像系统的成功，我们 提出了整合两者的创新条约成像系统的构建和临床测试 以前的系统可以使解剖成像和功能成像。双模式契约（DM PACT）将 结合双面光输送，大视图检测光圈和密集的声学采样 功能性和高分辨率解剖成像，以评估乳腺癌中与治疗相关的反应。这 DM-PACT产生的成像功能将首先进行表征和关联 切除的乳腺癌标本的组织病理学结果来自接受NAT治疗的患者。诊断 使用成像功能的模型将在接受治疗的较大的乳腺癌患者中训练和测试 与纳特。我们将比较DM-PACT的性能与SOC DCE-MRI在治疗中的表现 响应歧视。该项目的成功将导致成像技术指导响应 - 驱动的个性化乳腺癌治疗计划。