COMPARISON OF CYTOCHROME P4503A4 ACTIVITY IN FED AND FASTING HEALTHY SUBJECTS

进食和禁食健康受试者中细胞色素 P4503A4 活性的比较

• 批准号: 7368177
• 负责人: LILY LAU LAI
• 金额: $ 0.87万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368177
• 关键词: COMPARISON; CYTOCHROME; P4503A4; ACTIVITY; FED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using animal and in vitro models, we recently found that fasting results in induction of activity of CYP3A4, member of the hepatic cytochrome P450 enzymes. Our data further suggest that this activity is likely to occur in humans. Given the wide variability in dosing relative to time of food intake, our preclinical data suggest that the relationship between fasting/feeding and CYP3A4 activity could have broad implications for dosing as well as control of therapeutic and toxic effects of numerous pharmacologic agents. We propose to study the activity of CYP3A4 in fed and fasting normal volunteers through a tested and validated assay, the erythromycin breath test (ERBMT).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。使用动物和体外模型，我们最近发现禁食会导致肝细胞色素P450酶的CYP3A4活性诱导。我们的数据进一步表明，这种活动可能发生在人类中。鉴于相对于食物摄入时间的剂量差异很大，我们的临床前数据表明，禁食/喂养与CYP3A4活性之间的关系可能对剂量以及控制众多药理剂的治疗和有毒作用具有广泛的影响。我们建议通过经过测试和验证的测定，即红霉素呼气测试（ERBMT）研究CYP3A4在FED和禁食正常志愿者中的活性。