Synthetic analogues based on metabolites of omega-3 fatty acids protect mitochondria in aging hearts

基于 omega-3 脂肪酸代谢物的合成类似物可保护衰老心脏中的线粒体

• 批准号: 477891
• 负责人: Seubert John M
• 金额: $ 66.04万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=477891&lang=en
• 关键词: Aging; Cytochrome P450; Drug Development; Mitochondria; Omega-3 Pufa; Soluble Epoxide Hydrolase; Synthetic Compounds; Aging; Cytochrome P450; Drug Development; Mitochondria; Omega-3 Pufa; Soluble Epoxide Hydrolase; Synthetic Compounds

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in elderly individuals, where ischemic heart disease (IHD) is a major contributor. While aging is a natural process involving the progressive decline in biological systems, the eff

心血管疾病（CVD）是老年人发病率和死亡率的主要原因，缺血性心脏病（IHD）是主要贡献者。尽管衰老是一个自然过程，涉及生物系统的逐步下降，但EFF