AIR Option 1: Technology Translation: Prototyping a smart multi-dimensional micro-gas chromatography instrument with unprecedented peak capacity

AIR 选项 1：技术转化：原型设计具有前所未有的峰值容量的智能多维微型气相色谱仪

• 批准号: 1342917
• 负责人: Xudong Fan
• 金额: $ 15万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1342917&HistoricalAwards=false
• 关键词: AIR; Option; Technology; Translation; Prototyping

This PFI: AIR Technology Translation project focuses on translating smart multi-channel multi-dimensional micro-gas chromatography (MC-MD micro-GC) technology to fill portable and rapid vapor analysis gap. The translated smart MC-MD micro-GC has the following distinct advantages when compared with conventional 1-dimensional micro-GC or comprehensive 2-D micro-GC in the market or under development in labs. (1) It has unprecedented peak capacity and peak capacity efficiency while remaining portable, which arise from the long high-dimensional separation afforded by the smart GC design; (2) It can be scaled up to higher dimensional separation (such as 3-D or 4-D micro-GC) easily; (3) It does not require complicated thermal modulators widely used in comprehensive 2-D GC systems, thus substantially simplifying the GC design, fabrication, and power consumption; (4) Construction of the multi-dimensional (not only 2-D but also higher dimensional) chromatogram becomes straightforward by reading the retention time of each analyte directly from the vapor detector installed at the end of the each separation column; and (5) the detection limit is improved 3-10 fold, since the entire analyte is sent to the downstream column, rather than just a slice of it as in the conventional comprehensive 2-D GC. The project accomplishes this goal by prototyping a fully functional 1x2x4-channel smart 3-D micro-GC, which will include the following tasks: (1) assembly of all micro-GC components, (2) development of the corresponding operation/analysis algorithm, (3) performance evaluation using 100 vapor analytes, (4) assessment of market potential and commercialization feasibility, and (5) technical and entrepreneurial training of under/graduate students and post-doctors. The potential economic impact is expected to be a few billion US dollars in the next ten years which will contribute to the U.S. competitiveness in fields as diverse as agricultural and food industry, winery, environment monitoring/protection, healthcare, and homeland security/battlefield.Broader impact: Smart 3-D micro-GC has unprecedented peak capacity, easy operation, and simple 3-D chromatogram construction and thus will have a broad range of applications in environmental monitoring, homeland security, battlefield, industries, and healthcare. The students and the post-doctor will receive rigorous technical and entrepreneurial training and mentoring. Additionally, the team will work closely with the Master of Entrepreneurship Program at the University of Michigan to assess the market opportunities and viability of smart 3-D micro-GC. Dissemination of knowledge will include journal publications, conference presentations, patent filing, public seminars, and demonstration of the prototype at the science/technology exhibits in the Detroit area.

该PFI：空气技术翻译项目致力于翻译智能多渠道多维微型气相色谱（MC-MD Micro-GC）技术，以填补便携式和快速的蒸气分析差距。与传统的一维微型GC或实验室中的常规1维微型GC或综合的2-D Micro-GC相比，翻译后的MC-MD MICRO-GC具有以下不同的优势。 （1）它具有前所未有的峰值容量和峰值容量效率，同时保持便携式，这是由智能GC设计提供的长度高维间隔所产生的； （2）可以轻松地将其扩展到更高的尺寸分离（例如3-D或4-D Micro-GC）； （3）它不需要在综合的2-D GC系统中广泛使用的复杂热调节器，从而实质上简化了GC设计，制造和功耗； （4）通过直接从安装在每个分离柱末端安装的蒸气探测器中读取每个分析物的保留时间来构造多维（不仅是2-D和更高维度）色谱图，从而使色谱图变得直接； （5）由于将整个分析物发送到下游列，而不是像常规综合的2-D GC一样，将检测极限提高了3-10倍。该项目通过制作功能齐全的1x2x4通道SMART 3-D MICRO-GC来实现这一目标，其中包括以下任务：（1）所有MICRO-GC组件的组装，（1）（2）（2）开发相应的操作/分析算法的开发，（2）使用100级化合物分析和商业化的效率和商业化的效果，（4）效率评估，（4）效率和商业化的效果，以及（4）富富富；低于/研究生和研究生。预计在未来十年中，潜在的经济影响预计将有几十亿美元，这将有助于美国在农业和食品行业，酿酒厂，环境监控/保护，医疗保健和国土安全/战场的多样化领域的竞争力。安全，战场，行业和医疗保健。学生和后者将获得严格的技术和企业家培训和指导。此外，该团队将与密歇根大学的创业硕士计划紧密合作，以评估Smart 3-D Micro-GC的市场机会和可行性。知识的传播将包括期刊出版物，会议演讲，专利申请，公开研讨会以及底特律地区科学/技术展览的原型演示。