Wearable Nanoelectronic Vapor Sensors for Transdermal Alcohol Monitoring

用于透皮酒精监测的可穿戴纳米电子蒸汽传感器

• 批准号: 10255523
• 负责人: Girish Kulkarni
• 金额: $ 41.86万
• 依托单位: ARBORSENSE, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-10 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10255523
• 关键词: 3D Print; Abstinence; Address; Alcohol consumption; Alcohols; Attention; Awareness; Bacterial Artificial Chromosomes; Benchmarking; Blood; Bluetooth; Calibration; Cause of Death; Cessation of life; Computer software; Cost Analysis; Custom; Data; Data Storage and Retrieval; Development; Devices; Electronics; Engineering; Esthetics; Event; Exercise; Funding; Future; General Population; Goals; Grant; Hand; Health; Heavy Drinking; Human; Human Volunteers; Individual; Industrialization; Industry Standard; Intoxication; Investments; Journals; Legal; Legal patent; Letters; Light; Liver diseases; Location; Long-Term Effects; Methods; Michigan; Monitor; National Institute on Alcohol Abuse and Alcoholism; Participant; Patient Self-Report; Performance; Phase; Pilot Projects; Prevalence; Process; Production; Public Health; Readiness; Recovery; Resistance; Risk Behaviors; Security; Skin; Small Business Innovation Research Grant; Standardization; System; Techniques; Testing; Time; Travel; United States; Universities; Wireless Technology; Wrist; alcohol monitoring; alcohol use disorder; alcohol-related death; base; commercialization; cooking; cost effective; court; data exchange; design; drinking; field study; graphene; human subject; impression; improved; innovation; monitoring device; nanoelectronics; operation; programs; prototype; recruit; scale up; sensor; service providers; smartphone Application; social stigma; success; usability; vapor; wearable device

Project Summary In this Commercialization Readiness Pilot (CRP) Program project, Arborsense will develop field-ready wearable alcohol bio-monitors that are robust and comfortable to wear continuously while maintaining the functionality and performance demonstrated in Phase II, and conduct a field compliance study for 4 weeks to establish product- market fit. Excessive alcohol consumption is the fourth leading preventable cause of death in the US. Alcohol- related deaths have accelerated significantly in the past two decades as has the prevalence of other alcohol- related harms such as alcohol use disorder and alcohol-related liver disease. Arborsense’s wearable alcohol bio-monitor will address the unmet need for a continuous, convenient-to-use, and discreet device for monitoring alcohol consumption without discomfort or stigma. This will lead to better awareness and compliance with respect to alcohol use amongst the general public. Arborsense received an NSF Phase I SBIR grant (IIP-1548317) with which we demonstrated proof-of-concept graphene alcohol sensors and their feasibility in human volunteer tests. This led to an NIAAA Phase II SBIR grant (R44AA026119) that allowed us to build light, standalone, and wrist- worn sensor modules integrated with self-calibration electronics and Bluetooth transceiver to transmit data wirelessly to our custom Android app. In Phase II, we collaborated with the University of Michigan to validate these sensor modules in large scale human subject tests (82 human participants; more than 150 sensors tested in over 300 individual tests on multiple body locations). We have shown that our current modules can continuously and reliably detect drink events with peak BAC level >0.03% when benchmarked with legal grade breathalyzer and have very low false positives and low false negatives. In this CRP program, we will collaborate with Sundberg-Ferar (a Michigan based industrial design firm) and incorporate robustness, ergonomic refinements, and aesthetics to develop a rugged and high-fidelity system that will be utilized for a multi-week wear study through the University of Michigan. We will also engage with our strategic partners during the design process to incorporate features necessary for market acceptance. The successful performance of our bio- monitors in these real-world tests in terms of functionality and usability is a key milestone towards market approval and production development and will continue to provide investment momentum.

项目摘要 在这个商业化准备飞行员（CRP）计划项目中，Arborsense将开发可穿戴现场的可穿戴设备 酒精生物监控器可稳健且舒适地连续穿着，同时保持功能和 在第二阶段证明的绩效，并进行了4周的现场合规性研究，以建立产品 - 市场合身。过度饮酒是美国的第四个主要可预防原因。酒精- 在过去的二十年中，相关死亡已经显着加速，其他酒精的患病率也是如此 相关危害，例如酒精使用障碍和与酒精有关的肝病。 Arborsense的可穿戴酒精 生物监测器将满足对监视的连续，方便且谨慎的设备的未满足需求 饮酒无不适或污名。这将导致更好的意识和遵守尊重 在公众中使用酒精。 Arborsense获得了NSF I期SBIR Grant（IIP-1548317） 我们证明了概念验证的石墨烯酒精传感器及其在人类志愿者测试中的可行性。 这导致了NIAAA II期SBIR Grant（R44AA026119），使我们能够建立光，独立和手腕 - 与自校准电子设备和蓝牙收发器集成的磨损传感器模块以传输数据 无线至我们的自定义Android应用。在第二阶段，我们与密歇根大学合作以验证 这些传感器模块在大规模的人类受试者测试中（82名人类参与者；超过150个传感器测试 在多个身体位置的300多个单独测试中）。我们已经证明我们当前的模块可以 通过法律等级为基准时，连续可靠地检测到峰值BAC级别> 0.03％的饮料事件 呼吸分析仪，假阳性非常低，虚假负面因素低。在此CRP计划中，我们将合作 与Sundberg-Ferar（一家位于密歇根州的工业设计公司），并结合了鲁棒性，人体工程学 改进和美学，以开发坚固且高保真的系统，该系统将用于多周 通过密歇根大学穿着研究。在设计期间，我们还将与战略合作伙伴互动 纳入市场接受必要的功能的过程。我们的生物的成功表现 从功能和可用性方面，在这些现实世界测试中进行监视是迈向市场的关键里程碑 批准和生产开发，并将继续提供投资势头。