Metabolic Studies of Mouse Models of Obesity and Diabetes

肥胖和糖尿病小鼠模型的代谢研究

• 批准号: 10908946
• 负责人: Oksana Gavrilova
• 金额: $ 112.7万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10908946
• 关键词: Adipose tissue; Affect; Body Composition; Body Temperature; Brain region; Brown Fat; Cell Cycle; Cell physiology; Chemicals; Code; Complex; Deoxyglucose; Diabetes Mellitus; Diabetic mouse; Disease; Eating; Energy Metabolism; Enhancers; Erythropoietin; Focal and Segmental Glomerulosclerosis; Food Energy; G-Protein-Coupled Receptors; GNAS gene; GTP-Binding Proteins; Gender; Genetic; Glucose; Glycogen; Homeostasis; Hormones; Insulin; Islets of Langerhans; Laboratories; Measures; Mediating; Metabolic; Metabolism; Methyltransferase; Molecular; Morphology; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; Natural History; Obesity; Operative Surgical Procedures; Pathogenesis; Pharmacology; Phase; Phenotype; Physiological; Physiology; Prevalence; Principal Investigator; Purinergic P1 Receptors; RGS Proteins; Regulation; Research Personnel; Role; Serum; Services; Signal Transduction; Societies; Standardization; Testing; Tissues; Transforming Growth Factor beta; Triglycerides; Tubular formation; bombesin receptor subtype 3; cell growth; drug action; drug development; energy balance; epigenomics; glucose metabolism; glucose tolerance; insulin secretion; insulin tolerance; lipid biosynthesis; metabolic abnormality assessment; mouse model; neurotransmission; nonalcoholic steatohepatitis; programs; protein kinase D; receptor; response; uptake

The following projects have been supported by Mouse Metabolism Core in FY 2023: 1. DK075021 Role of G protein-coupled receptors in regulating glucose and energy homeostasis Principal Investigator: Hans Jurgen Wess (LBC, NIDDK) 2. DK043313 Role of the Gnas Gene in Metabolic Regulation Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 3. DK043315 Role of Gs-alpha in central regulation of energy and glucose metabolism Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 4. DK043318 Role of Gs-alpha in pancreatic islet cell growth and function Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 5. DK075056 Role of Gq/11-alpha in metabolic regulation Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 6. DK031117 Development of drugs acting at adenosine receptors Principal Investigator: Kenneth A. Jacobson (LBC, NIDDK) 7. DK075057 DEOB Physiology and pharmacology of BRS-3 (Bombesin Receptor Subtype-3) Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 8. DK075063 What can body temperature tell us about energy homeostasis? Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 9. DK075064 Role of brown adipose tissue (BAT) in energy balance Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 10. DK075003 Epigenomic regulation of adipogenesis and adipose expansion Enhancer regulation by H3K4 methyltransferase MLL4/KMT2D and associated factors Principal Investigator: Kai Ge (LERB, NIDDK) 11. DK055106 Transforming growth factor - beta superfamily signaling in diabetes and obesity Principal Investigator: Sushil Rane (DEOB, NIDDK) 12. DK055107 Cell cycle regulators in diabetes and obesity Principal Investigator: Sushil Rane (DEOB, NIDDK) 13. DK075013 Nonalcoholic Steatohepatitis: Natural History, Pathogenesis and Therapy Principal Investigator: Yaron Rotman (LDB, NIDDK) 14. DK043304 Mechanism of G Protein Beta5/ R7-RGS Protein/ R7BP Complex Signal Transduction Principal Investigator: William F. Simonds (MDB, NIDDK) 15. DK025061 Receptor Mediated Erythropoietin Metabolic Response and Gender Specific Activity Principal Investigator: Constance T. Noguchi (MCB, NIDDK) 16. DK043308 Focal Segmental Glomerulosclerosis: Genetics & Mechanisms Principal Investigator: Jeffrey B.Kopp (KDB, NIDDK) 17. DK075042 The role of PKD proteins in regulating tubular morphology Principal Investigator: Gregory G. Germino (KDB, MIDDK) 18. MH002386 Chemical Coding of Neurotransmission Principal Investigator: Lee E. Eiden (LCMR, NIMH)

2023 财年 Mouse Metabolism Core 支持以下项目： 1.DK075021 G蛋白偶联受体在调节葡萄糖和能量稳态中的作用 首席研究员：Hans Jurgen Wess（LBC、NIDDK） 2.DK043313 Gnas 基因在代谢调节中的作用 首席研究员：Lee S. Weinstein（MDB、NIDDK） 3.DK043315 Gs-α 在能量和葡萄糖代谢中枢调节中的作用 首席研究员：Lee S. Weinstein（MDB、NIDDK） 4.DK043318 Gs-α 在胰岛细胞生长和功能中的作用 首席研究员：Lee S. Weinstein（MDB、NIDDK） 5.DK075056 Gq/11-alpha 在代谢调节中的作用 首席研究员：Lee S. Weinstein（MDB、NIDDK） 6.DK031117 开发作用于腺苷受体的药物 首席研究员：Kenneth A. Jacobson（LBC、NIDDK） 7. DK075057 德奥布 BRS-3（铃蟾肽受体亚型 3）的生理学和药理学 首席研究员：Marc L. Reitman（DEOB、NIDDK） 8.DK075063 体温可以告诉我们关于能量稳态的什么信息？ 首席研究员：Marc L. Reitman（DEOB、NIDDK） 9.DK075064 棕色脂肪组织（BAT）在能量平衡中的作用 首席研究员：Marc L. Reitman（DEOB、NIDDK） 10.DK075003 脂肪生成和脂肪扩张的表观基因组调控 H3K4 甲基转移酶 MLL4/KMT2D 和相关因子的增强子调节 首席研究员：葛凯（LERB、NIDDK） 11.DK055106 糖尿病和肥胖症中的转化生长因子 - β 超家族信号传导 首席研究员：Sushil Rane（DEOB、NIDDK） 12.DK055107 糖尿病和肥胖症中的细胞周期调节剂 首席研究员：Sushil Rane（DEOB、NIDDK） 13.DK075013 非酒精性脂肪性肝炎：自然史、发病机制和治疗 首席研究员：Yaron Rotman（LDB、NIDDK） 14.DK043304 G蛋白Beta5/ R7-RGS蛋白/ R7BP复合物信号转导机制 首席研究员：William F. Simonds（MDB、NIDDK） 15.DK025061 受体介导的促红细胞生成素代谢反应和性别特异性活性 首席研究员：Constance T. Noguchi（MCB、NIDDK） 16.DK043308 局灶节段性肾小球硬化：遗传学与机制 首席研究员：Jeffrey B.Kopp（KDB、NIDDK） 17.DK075042 PKD蛋白在调节肾小管形态中的作用 首席研究员：Gregory G. Germino（KDB、MIDDK） 18.MH002386 神经传递的化学编码 首席研究员：Lee E. Eiden（LCMR、NIMH）

项目成果

A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice.

• DOI: 10.1371/journal.pgen.1002307
• 发表时间: 2011-09
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Kurima K;Hertzano R;Gavrilova O;Monahan K;Shpargel KB;Nadaraja G;Kawashima Y;Lee KY;Ito T;Higashi Y;Eisenman DJ;Strome SE;Griffith AJ
• 通讯作者: Griffith AJ

Corrigendum to "Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism" [Mol Metabol 6 (2017) 1540-1550].

“调节能量代谢需要铃贝素样受体 3 (Brs3) 在谷氨酸能神经元（而非 GABA 能神经元）中的表达”[Mol Metabol 6 (2017) 1540-1550]。

• DOI: 10.1016/j.molmet.2017.12.009
• 发表时间: 2018
• 期刊: Molecular metabolism
• 影响因子: 8.1
• 作者: Xiao,Cuiying;Piñol,RamónA;Carlin,JesseLea;Li,Cuiling;Deng,Chuxia;Gavrilova,Oksana;Reitman,MarcL
• 通讯作者: Reitman,MarcL