Metabolic Studies of Mouse Models of Obesity and Diabetes

肥胖和糖尿病小鼠模型的代谢研究

基本信息

批准号：
9352196
负责人：
Oksana Gavrilova
金额：
$ 72.47万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9352196
关键词：
Adipose tissue Affect Animals Biology Body Composition Body Temperature Brown Fat Cell Cycle Colon Carcinoma Diabetes Mellitus Diabetic mouse Diet Disease Eating Endocrine Energy Metabolism Erythropoietin Receptor GTP-Binding Protein alpha Subunits, Gs Genes Genetic Glucagon Glucose Glutamates Glycogen Growth Homeostasis Hormones Immunity Inborn Errors of Metabolism Infection Islets of Langerhans Transplantation Laboratories Life Measures Metabolic Metabolism Molecular Molecular Genetics Mus Muscarinic Acetylcholine Receptor Muscle National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases Natural History Obesity Pancreas Pathogenesis Pharmacology Phase Phenotype Physiological Physiology Play Prevalence Principal Investigator Production Protein p53 Purinergic P1 Receptors Pyruvate Rattus Regulation Research Personnel Role Serum Services Signal Transduction Societies Source Sphingolipids Testing Thermogenesis Tissues Transforming Growth Factor beta Triglycerides Tumor Suppressor Proteins Xenobiotics adrenal cortex tumor base bombesin receptor subtype 3 drug development energy balance fatty acid oxidation glucose metabolism glucose tolerance insulin secretion insulin tolerance islet metabolic abnormality assessment metabolic rate mouse model nonalcoholic steatohepatitis novel olfactomedin pancreatic islet function programs receptor tumor progression tumorigenesis

项目摘要

The following projects have been supported by Mouse Metabolism Core Laboratory in FY 2016: 1. DK031131 Role of muscarinic acetylcholine receptors in glucose and energy homeostasis Principal Investigator: Jurgen Wess (LBC, NIDDK) 2. DK043313 Role of the Gnas Gene in Metabolic Regulation Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 3. DK043315 Role of Gs-alpha in central regulation of energy and glucose metabolism Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 4. DK043316 Role of Gs-alpha in regulation of adipose tissue growth and function Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 5. DK025102 Erythropoietin receptor and glucose metabolism Principal Investigator: Constance T Noguchi (MCB, NIDDK) 6. DK031117 Development of drugs acting at adenosine receptors Principal Investigator: Kenneth A Jacobson (MR, NIDDK) 7. DK075057 DEOB Physiology and pharmacology of BRS-3 (Bombesin Receptor Subtype-3) Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 8. DK075063 What can body temperature tell us about energy homeostasis? Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 9. DK075064 Role of brown adipose tissue (BAT) in energy balance Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 10. DK056018 Sphingolipid biology and regulation of metabolism Principal Investigator: Richard L Proia (GDDB, NIDDK) 11. DK056014 Mouse models of novel sphingolipid biology and disease Principal Investigator: Richard L Proia (GDDB, NIDDK) 12. DK075035 Genes associated with endocrine tumorigenesis Principal Investigator: Sunita K Agarwal (MDB, NIDDK) 13. DK055106 Transforming growth factor - beta superfamily signaling in diabetes and obesity Principal Investigator: Sushil Rane (DEOB, NIDDK) 14. DK055107 Cell cycle regulators in diabetes and obesity Principal Investigator: Sushil Rane (DEOB, NIDDK) 15. DK075096-02 Does the Drd2 receptor play a causal role in obesity? Principal Investigator: Alexxai V. Kravitz (DEOB, NIDDK) 16. DK075013 Nonalcoholic steatohepatitis: natural History, pathogenesis and therapy Principal Investigator: Yaron Rotman (LDB, NIDDK) 17. HL006004-07 Olfactomedin 4 is a key regulator of colon cancer progression Principal Investigator: Griffin P Rodgers (MCHB, NHLBI) 18. BC005708 Xenobiotic receptors Principal Investigator: Frank J Gonzalez (LM, NCI) 19. BC005599 Tumor Suppressor Protein, p53 Principal Investigator: Ettore Appella (LCB, NCI) 20. HD000642 Molecular Genetics of Adrenocortical Tumors And Related Disorders Principal Investigator: Constantine A Stratakis (PDEG, NICHD) 21. HG200381 Metabolism, infection and immunity in inborn errors of metabolism Principal Investigator: Peter J. McGuire (MGMGB, NHGRI)

2016财年，小鼠代谢核心实验室资助了以下项目： 1.DK031131 毒蕈碱乙酰胆碱受体在葡萄糖和能量稳态中的作用首席研究员：Jurgen Wess（LBC、NIDDK） 2.DK043313 Gnas 基因在代谢调节中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 3.DK043315 Gs-α 在能量和葡萄糖代谢中枢调节中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 4.DK043316 Gs-α 在调节脂肪组织生长和功能中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 5.DK025102 促红细胞生成素受体与葡萄糖代谢首席研究员：Constance T Noguchi（MCB、NIDDK） 6.DK031117 开发作用于腺苷受体的药物首席研究员：Kenneth A Jacobson（MR，NIDDK） 7. DK075057 德奥布 BRS-3（铃蟾肽受体亚型 3）的生理学和药理学首席研究员：Marc L. Reitman（DEOB、NIDDK） 8.DK075063 体温可以告诉我们关于能量稳态的什么信息？首席研究员：Mark L. Reitman（DEOB、NIDDK） 9.DK075064 棕色脂肪组织（BAT）在能量平衡中的作用首席研究员：Mark L. Reitman（DEOB、NIDDK） 10.DK056018 鞘脂生物学和代谢调节首席研究员：Richard L Proia（GDDB、NIDDK） 11.DK056014 新型鞘脂生物学和疾病的小鼠模型首席研究员：Richard L Proia（GDDB、NIDDK） 12.DK075035 与内分泌肿瘤发生相关的基因首席研究员：Sunita K Agarwal（MDB、NIDDK） 13.DK055106 糖尿病和肥胖症中的转化生长因子 - β 超家族信号传导首席研究员：Sushil Rane（DEOB、NIDDK） 14.DK055107 糖尿病和肥胖症中的细胞周期调节剂首席研究员：Sushil Rane（DEOB、NIDDK） 15.DK075096-02 Drd2 受体是否与肥胖有关？首席研究员：Alexxai V. Kravitz（DEOB、NIDDK） 16.DK075013 非酒精性脂肪性肝炎：自然史、发病机制和治疗首席研究员：Yaron Rotman（LDB、NIDDK） 17.HL006004-07 Olfactomedin 4 是结肠癌进展的关键调节因子首席研究员：Griffin P Rodgers（MCHB、NHLBI） 18.BC005708 异生素受体首席研究员：Frank J Gonzalez（LM，NCI） 19.BC005599 肿瘤抑制蛋白，p53 首席研究员：Ettore Appella（LCB、NCI） 20.HD000642 肾上腺皮质肿瘤及相关疾病的分子遗传学首席研究员：Constantine A Stratakis（PDEG、NICHD） 21.HG200381 先天性代谢缺陷中的代谢、感染和免疫首席研究员：Peter J. McGuire（MGMGB、NHGRI）