Metabolic Studies of Mouse Models of Obesity and Diabetes

肥胖和糖尿病小鼠模型的代谢研究

基本信息

批准号：
9775044
负责人：
Oksana Gavrilova
金额：
$ 40.62万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9775044
关键词：
Adipose tissue Affect Ascorbic Acid Body Composition Body Temperature Brain region Brown Fat Cell Cycle Development Diabetes Mellitus Diabetic mouse Disease Eating Energy Metabolism Epigenetic Process Erythropoietin Receptor Food Energy GNAS gene GTP-Binding Protein alpha Subunits, Gs Genes Genetic Glucose Glycogen Growth Homeostasis Hormones Human Insulin Iron Islets of Langerhans Laboratories Measures Metabolic Metabolism Molecular Molecular Genetics Mus Muscarinic Acetylcholine Receptor National Heart, Lung, and Blood Institute National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases Natural History Nervous system structure OLFM4 gene Obesity Operative Surgical Procedures Pathogenesis Pathologic Pharmacology Phase Phenotype Physiological Physiology Prevalence Principal Investigator Purinergic P1 Receptors Regulation Research Personnel Role Satiation Serum Services Signal Transduction Societies Standardization Testing Tissues Transforming Growth Factor beta Triglycerides Xenobiotics adrenal cortex tumor bombesin receptor subtype 3 colon cancer progression drug development energy balance epigenetic regulation glucose metabolism glucose tolerance glucose uptake insulin secretion insulin tolerance lipid biosynthesis metabolic abnormality assessment mouse model neural circuit neurotrophic factor nonalcoholic steatohepatitis programs receptor ubiquitin-protein ligase

项目摘要

The following projects have been supported by Mouse Metabolism Core in FY 2018: 1. DK031131 Role of muscarinic acetylcholine receptors in glucose and energy homeostasis Principal Investigator: Jurgen Wess (LBC, NIDDK) 2. DK043313 Role of the Gnas Gene in Metabolic Regulation Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 3. DK043315 Role of Gs-alpha in central regulation of energy and glucose metabolism Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 4. DK043316 Role of Gs-alpha in regulation of adipose tissue growth and function Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 5. DK025102 Erythropoietin receptor and glucose metabolism Principal Investigator: Constance T Noguchi (MCB, NIDDK) 6. DK031117 Development of drugs acting at adenosine receptors Principal Investigator: Kenneth A Jacobson (MR, NIDDK) 7. DK075057 DEOB Physiology and pharmacology of BRS-3 (Bombesin Receptor Subtype-3) Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 8. DK075063 What can body temperature tell us about energy homeostasis? Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 9. DK075064 Role of brown adipose tissue (BAT) in energy balance Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 10. DK055106 Transforming growth factor - beta superfamily signaling in diabetes and obesity Principal Investigator: Sushil Rane (DEOB, NIDDK) 11. DK055107 Cell cycle regulators in diabetes and obesity Principal Investigator: Sushil Rane (DEOB, NIDDK) 12. DK075017 Epigenetic Regulation of Adipogenesis Principal Investigator: Kai Ge (LERB, NIDDK) 13. DK075013 Nonalcoholic steatohepatitis: natural History, pathogenesis and therapy Principal Investigator: Yaron Rotman (LDB, NIDDK) 14. DK054510 Identification of human genes of iron homeostasis Principal Investigator: Caroline C Philpott (LDB, NIDDK) 15. DK075033 Epigenetic and Developmental Regulation of Mammalian Genes Principal Investigator: Ann Dean (LCDB, NIDDK) 16. DK053218 Vitamin C (ascorbic acid) physiology Principal Investigator: Mark A Levine (DDB, NIDDK) 17. HL006004-07 Olfactomedin 4 is a key regulator of colon cancer progression Principal Investigator: Griffin P Rodgers (MCHB, NHLBI) 18. DK075087 Probing neural circuits underlying satiety Principal Investigator: Michael J Krashes (DEOB, NIDDK) 19. BC005708 Xenobiotic receptors Principal Investigator: Frank J Gonzalez (LM, NCI) 20. BC010390 Role of Neurotrophins in the Development of the Mammalian Nervous System Principal Investigator: Lino Tessarollo (MCGP, NCI) 21. BC011168 Physiological and pathological functions of E3 ubiquitin ligase SMURF. Principal Investigator: Ying Zhang (LCMB, NCI) 22. HD000642 Molecular Genetics of Adrenocortical Tumors and Related Disorders Principal Investigator: Constantine A Stratakis (PDEG, NICHD)

2018财年小鼠代谢核心支持了以下项目： 1.DK031131 毒蕈碱乙酰胆碱受体在葡萄糖和能量稳态中的作用首席研究员：Jurgen Wess（LBC、NIDDK） 2.DK043313 Gnas 基因在代谢调节中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 3.DK043315 Gs-α 在能量和葡萄糖代谢中枢调节中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 4.DK043316 Gs-α 在调节脂肪组织生长和功能中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 5.DK025102 促红细胞生成素受体与葡萄糖代谢首席研究员：Constance T Noguchi（MCB、NIDDK） 6.DK031117 开发作用于腺苷受体的药物首席研究员：Kenneth A Jacobson（MR，NIDDK） 7. DK075057 德奥布 BRS-3（铃蟾肽受体亚型 3）的生理学和药理学首席研究员：Marc L. Reitman（DEOB、NIDDK） 8.DK075063 体温可以告诉我们关于能量稳态的什么信息？首席研究员：Mark L. Reitman（DEOB、NIDDK） 9.DK075064 棕色脂肪组织（BAT）在能量平衡中的作用首席研究员：Mark L. Reitman（DEOB、NIDDK） 10.DK055106 糖尿病和肥胖症中的转化生长因子 - β 超家族信号传导首席研究员：Sushil Rane（DEOB、NIDDK） 11.DK055107 糖尿病和肥胖症中的细胞周期调节剂首席研究员：Sushil Rane（DEOB、NIDDK） 12.DK075017 脂肪生成的表观遗传调控首席研究员：葛凯（LERB、NIDDK） 13.DK075013 非酒精性脂肪性肝炎：自然史、发病机制和治疗首席研究员：Yaron Rotman（LDB、NIDDK） 14.DK054510 人类铁稳态基因的鉴定首席研究员：Caroline C Philpott（LDB、NIDDK） 15.DK075033 哺乳动物基因的表观遗传和发育调控首席研究员：Ann Dean（LCDB、NIDDK） 16.DK053218 维生素 C（抗坏血酸）生理学首席研究员：Mark A Levine（DDB、NIDDK） 17.HL006004-07 Olfactomedin 4 是结肠癌进展的关键调节因子首席研究员：Griffin P Rodgers（MCHB、NHLBI） 18.DK075087 探究饱腹感背后的神经回路首席研究员：Michael J Krashes（DEOB、NIDDK） 19.BC005708 异生素受体首席研究员：Frank J Gonzalez（LM，NCI） 20.BC010390 神经营养素在哺乳动物神经系统发育中的作用首席研究员：Lino Tessarollo（MCGP、NCI） 21.BC011168 E3泛素连接酶SMURF的生理和病理功能。首席研究员：张颖（LCMB、NCI） 22.HD000642 肾上腺皮质肿瘤及相关疾病的分子遗传学首席研究员：Constantine A Stratakis（PDEG、NICHD）