Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
基本信息
- 批准号:9555746
- 负责人:
- 金额:$ 40.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:Adipose tissueAffectAnimal Disease ModelsBiologyBody CompositionBody TemperatureBrain regionBrown FatCell CycleColon CarcinomaDiabetes MellitusDiabetic mouseDiseaseDopamine D2 ReceptorEatingEndocrineEnergy MetabolismEnzymesErythropoietin ReceptorFood EnergyGNAS geneGTP-Binding Protein alpha Subunits, GsGenesGeneticGlucoseGlycogenGrowthHomeostasisHormonesHumanImmunityInborn Errors of MetabolismInfectionInsulinIronIslets of LangerhansLaboratoriesMeasuresMetabolicMetabolismMolecularMolecular GeneticsMusMuscarinic Acetylcholine ReceptorNational Heart, Lung, and Blood InstituteNational Human Genome Research InstituteNational Institute of Child Health and Human DevelopmentNational Institute of Diabetes and Digestive and Kidney DiseasesNatural HistoryOLFM4 geneObesityOperative Surgical ProceduresPathogenesisPharmacologyPhasePhenotypePhysiologicalPhysiologyPlayPrevalencePrincipal InvestigatorPsychologyPurinergic P1 ReceptorsRegulationResearch PersonnelRoleSerumServicesSignal TransductionSocietiesSphingolipidsStandardizationTestingTissuesTransforming Growth Factor betaTriglyceridesXenobioticsadrenal cortex tumorbombesin receptor subtype 3drug developmentenergy balanceepigenetic regulationglucose metabolismglucose toleranceglucose uptakeinsulin secretioninsulin tolerancelipid biosynthesismetabolic abnormality assessmentmouse modelnonalcoholic steatohepatitisnovelprogramsreceptortumor progressiontumorigenesis
项目摘要
The following projects have been supported by Mouse Metabolism Core in FY 2017:
1. DK031131
Role of muscarinic acetylcholine receptors in glucose and energy homeostasis
Principal Investigator: Jurgen Wess (LBC, NIDDK)
2. DK043313
Role of the Gnas Gene in Metabolic Regulation
Principal Investigator: Lee S. Weinstein (MDB, NIDDK)
3. DK043315
Role of Gs-alpha in central regulation of energy and glucose metabolism
Principal Investigator: Lee S. Weinstein (MDB, NIDDK)
4. DK043316
Role of Gs-alpha in regulation of adipose tissue growth and function
Principal Investigator: Lee S. Weinstein (MDB, NIDDK)
5. DK025102
Erythropoietin receptor and glucose metabolism
Principal Investigator: Constance T Noguchi (MCB, NIDDK)
6. DK031117
Development of drugs acting at adenosine receptors
Principal Investigator: Kenneth A Jacobson (MR, NIDDK)
7. DK075057 DEOB
Physiology and pharmacology of BRS-3 (Bombesin Receptor Subtype-3)
Principal Investigator: Marc L. Reitman (DEOB, NIDDK)
8. DK075063
What can body temperature tell us about energy homeostasis?
Principal Investigator: Mark L. Reitman (DEOB, NIDDK)
9. DK075064
Role of brown adipose tissue (BAT) in energy balance
Principal Investigator: Mark L. Reitman (DEOB, NIDDK)
10. DK056018
Sphingolipid biology and regulation of metabolism
Principal Investigator: Richard L Proia (GDDB, NIDDK)
11. DK056014
Mouse models of novel sphingolipid biology and disease
Principal Investigator: Richard L Proia (GDDB, NIDDK)
12. DK075035
Genes associated with endocrine tumorigenesis
Principal Investigator: Sunita K Agarwal (MDB, NIDDK)
13. DK055106
Transforming growth factor - beta superfamily signaling in diabetes and obesity
Principal Investigator: Sushil Rane (DEOB, NIDDK)
14. DK055107
Cell cycle regulators in diabetes and obesity
Principal Investigator: Sushil Rane (DEOB, NIDDK)
15. DK075017
Epigenetic Regulation of Adipogenesis
Principal Investigator: Kai Ge (LERB, NIDDK)
16. DK075096-02
Does the Drd2 receptor play a causal role in obesity?
Principal Investigator: Alexxai V. Kravitz (DEOB, NIDDK)
17. DK075013
Nonalcoholic steatohepatitis: natural History, pathogenesis and therapy
Principal Investigator: Yaron Rotman (LDB, NIDDK)
18. DK060101
Targeted disruption the enzymes of O-GlcNAc cycling: animal models of disease
Principal Investigator: John A Hanover (LCMB, NIDDK)
19. DK054510
Identification of human genes of iron homeostasis
Caroline C Philpott (LDB, NIDDK)
20. HL006004-07
Olfactomedin 4 is a key regulator of colon cancer progression
Principal Investigator: Griffin P Rodgers (MCHB, NHLBI)
21. BC005708
Xenobiotic receptors
Principal Investigator: Frank J Gonzalez (LM, NCI)
22. HD000642
Molecular Genetics of Adrenocortical Tumors And Related Disorders
Principal Investigator: Constantine A Stratakis (PDEG, NICHD)
23. HG200381
Metabolism, infection and immunity in inborn errors of metabolism
Principal Investigator: Peter J. McGuire (MGMGB, NHGRI)
24. HD000641
Physiology, psychology, and genetics of obesity
Principal Investigator: Jack A. Yanovski (UGO, NICHD)
2017财年,以下项目得到了Mouse Metabolism Core的支持:
1.DK031131
毒蕈碱乙酰胆碱受体在葡萄糖和能量稳态中的作用
首席研究员:Jurgen Wess(LBC、NIDDK)
2.DK043313
Gnas 基因在代谢调节中的作用
首席研究员:Lee S. Weinstein(MDB、NIDDK)
3.DK043315
Gs-α 在能量和葡萄糖代谢中枢调节中的作用
首席研究员:Lee S. Weinstein(MDB、NIDDK)
4.DK043316
Gs-α 在调节脂肪组织生长和功能中的作用
首席研究员:Lee S. Weinstein(MDB、NIDDK)
5.DK025102
促红细胞生成素受体与葡萄糖代谢
首席研究员:Constance T Noguchi(MCB、NIDDK)
6.DK031117
开发作用于腺苷受体的药物
首席研究员:Kenneth A Jacobson(MR,NIDDK)
7. DK075057 德奥布
BRS-3(铃蟾肽受体亚型 3)的生理学和药理学
首席研究员:Marc L. Reitman(DEOB、NIDDK)
8.DK075063
体温可以告诉我们关于能量稳态的什么信息?
首席研究员:Mark L. Reitman(DEOB、NIDDK)
9.DK075064
棕色脂肪组织(BAT)在能量平衡中的作用
首席研究员:Mark L. Reitman(DEOB、NIDDK)
10.DK056018
鞘脂生物学和代谢调节
首席研究员:Richard L Proia(GDDB、NIDDK)
11.DK056014
新型鞘脂生物学和疾病的小鼠模型
首席研究员:Richard L Proia(GDDB、NIDDK)
12.DK075035
与内分泌肿瘤发生相关的基因
首席研究员:Sunita K Agarwal(MDB、NIDDK)
13.DK055106
糖尿病和肥胖症中的转化生长因子 - β 超家族信号传导
首席研究员:Sushil Rane(DEOB、NIDDK)
14.DK055107
糖尿病和肥胖症中的细胞周期调节剂
首席研究员:Sushil Rane(DEOB、NIDDK)
15.DK075017
脂肪生成的表观遗传调控
首席研究员:葛凯(LERB、NIDDK)
16.DK075096-02
Drd2 受体是否与肥胖有关?
首席研究员:Alexxai V. Kravitz(DEOB、NIDDK)
17.DK075013
非酒精性脂肪性肝炎:自然史、发病机制和治疗
首席研究员:Yaron Rotman(LDB、NIDDK)
18.DK060101
靶向破坏 O-GlcNAc 循环酶:疾病动物模型
首席研究员:John A Hanover(LCMB、NIDDK)
19.DK054510
人类铁稳态基因的鉴定
卡罗琳·C·菲尔波特(LDB、NIDDK)
20.HL006004-07
Olfactomedin 4 是结肠癌进展的关键调节因子
首席研究员:Griffin P Rodgers(MCHB、NHLBI)
21.BC005708
异生素受体
首席研究员:Frank J Gonzalez(LM,NCI)
22.HD000642
肾上腺皮质肿瘤及相关疾病的分子遗传学
首席研究员:Constantine A Stratakis(PDEG、NICHD)
23.HG200381
先天性代谢缺陷中的代谢、感染和免疫
首席研究员:Peter J. McGuire(MGMGB、NHGRI)
24.HD000641
肥胖的生理学、心理学和遗传学
首席研究员:Jack A. Yanovski(UGO、NICHD)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Oksana Gavrilova其他文献
Oksana Gavrilova的其他文献
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{{ truncateString('Oksana Gavrilova', 18)}}的其他基金
Metabolic Studies of Mouse Models of Obesity & Diabetes
肥胖小鼠模型的代谢研究
- 批准号:
7153591 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
- 批准号:
10908946 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
- 批准号:
8741642 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
- 批准号:
8149681 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
- 批准号:
9352196 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
- 批准号:
8940145 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
- 批准号:
9775044 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
- 批准号:
10682310 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
Metabolic Studies of Mouse Models of Obesity and Diabetes
肥胖和糖尿病小鼠模型的代谢研究
- 批准号:
7970081 - 财政年份:
- 资助金额:
$ 40.57万 - 项目类别:
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Project 2: Role of LPCAT3 in Adipose Remodeling and Metabolic Diseases
项目2:LPCAT3在脂肪重塑和代谢疾病中的作用
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