Project 2: Role of LPCAT3 in Adipose Remodeling and Metabolic Diseases

项目2：LPCAT3在脂肪重塑和代谢疾病中的作用

基本信息

批准号：
10594468
负责人：
Mi Jeong Lee
金额：
$ 32.91万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-20 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10594468
关键词：
Acyltransferase Adipocytes Adipose tissue Affect Animal Model Animals Berry Bioenergetics Biological Models Brown Fat Cardiometabolic Disease Cells Chronic Critical Pathways Data Dietary Factors Dietary Fats Endocrine Endocrine Glands Energy Metabolism Enzymes Fatty Acids Fatty acid glycerol esters Fish Oils Food Generations Genes Goals Health Health Benefit High Fat Diet Homeostasis Human Impairment Inflammation Inflammatory Inflammatory Response Knockout Mice Lead Lipids Lysophosphatidylcholines Mediating Membrane Membrane Biology Mentors Metabolic Metabolic Diseases Metabolism Molecular Monounsaturated Fatty Acids Obesity Omega-3 Fatty Acids Outcome Overnutrition Pathway interactions Persons Phospholipid Metabolism Phospholipids Physiological Play Polyunsaturated Fatty Acids Production Property Public Health Quality of life Risk Rodent Model Role Saturated Fatty Acids Science Signaling Molecule Testing Texas Therapeutic Tokyo Work adiponectin cardiometabolic risk cytokine fatty acid supplementation improved in vivo insulin signaling knock-down lard lipid metabolism lipidome mouse model new therapeutic target novel nutrition precision nutrition prevent professor protective effect response saturated fat transcriptome uncoupling protein 1

项目摘要

Project 2: Role of LPCAT3 in Adipose Remodeling Mi-Jeong Lee, Assistant Professor, Dept. of Human Nutrition, Food and Animal Sciences, CTAHR Higher mass of dysfunctional adipose tissues in obesity increases risk of metabolic diseases, a major public health concern. Dietary factors are important regulators of adipose remodeling and systemic energy metabolism. Lard-based high fat diets induce excessive remodeling of adipose tissues in animal models of obesity and metabolic diseases. Depending on types of fat used, their effects on metabolic health vary and omega-3 poly- unsaturated fatty acids enriched in fish oil have health benefits while saturated fatty acids impair insulin signaling and induce proinflammatory responses. The objective of our work is to elucidate the molecular details and mechanisms through which omega-3 vs. saturated fat exerts protective effects on adipose tissue function and systemic metabolism. We will test a novel hypothesis that omega-3 poly-unsaturated fatty acids lead to healthier remodeling of adipose tissues through incorporation into membrane phospholipids altering membrane biology and production of bioactive lipids. We will assess the importance of a phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase (LPCAT) 3, which preferentially add poly-unsaturated fatty acids into membrane phospholipids, in mediating the beneficial effects of omega-3 poly-unsaturated fatty acids. The proposed studies are expected to identify new strategies to improve adipose tissue function and hence, systemic metabolic health.

项目2：LPCAT3在脂肪重塑中的作用 Mi-Jeong Lee，CTAHR 人类营养、食品和动物科学系助理教授肥胖者中功能失调的脂肪组织数量较多，会增加代谢疾病的风险，这是一个主要公众关注的问题健康问题。饮食因素是脂肪重塑和全身能量代谢的重要调节因素。以猪油为基础的高脂肪饮食会导致肥胖动物模型中脂肪组织的过度重塑代谢性疾病。根据所使用的脂肪类型，它们对代谢健康的影响各不相同，omega-3 多聚鱼油中富含的不饱和脂肪酸对健康有益，而饱和脂肪酸会损害胰岛素信号并诱导促炎症反应。我们工作的目标是阐明分子细节并 omega-3 与饱和脂肪对脂肪组织功能发挥保护作用的机制全身代谢。我们将测试一个新的假设，即 omega-3 多不饱和脂肪酸可以使人更健康通过掺入膜磷脂来重塑脂肪组织，改变膜生物学和生物活性脂质的生产。我们将评估磷脂重塑酶的重要性溶血磷脂酰胆碱酰基转移酶（LPCAT）3，优先将多不饱和脂肪酸添加到膜磷脂，介导 omega-3 多不饱和脂肪酸的有益作用。这拟议的研究预计将确定改善脂肪组织功能的新策略，从而改善全身性代谢健康。