Metabolic Studies of Mouse Models of Obesity and Diabetes

肥胖和糖尿病小鼠模型的代谢研究

基本信息

批准号：
8940145
负责人：
Oksana Gavrilova
金额：
$ 54.13万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8940145
关键词：
Adipose tissue Affect Animal Disease Models Animals Biology Body Composition Body Temperature Brown Fat Cell Cycle Development Diabetes Mellitus Diabetic mouse Diet Disease Eating Endocrine Energy Metabolism Enzymes Epigenetic Process Erythropoietin Receptor GTP-Binding Protein alpha Subunits, Gs Genes Genetic Glucagon Glucose Glutamates Glycogen Growth Homeostasis Hormones Human Insulin Islets of Langerhans Transplantation Laboratories Life Ligands Measures Metabolic Metabolism Molecular Molecular Genetics Mus Muscarinic Acetylcholine Receptor Muscle National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases Obesity Organ PPAR gamma Pancreas Pathway interactions Pharmacology Phase Phenotype Physiological Physiology Prevalence Principal Investigator Production Psychology Pyruvate Rattus Regulation Research Personnel Role Serum Services Signal Transduction Societies Source Sphingolipids Testing Thermogenesis Tissues Transforming Growth Factor beta Triglycerides Xenobiotics adrenal cortex tumor base bombesin receptor subtype 3 energy balance fatty acid oxidation glucose metabolism glucose tolerance insulin secretion insulin tolerance islet lipid biosynthesis metabolic abnormality assessment mouse model novel pancreatic islet function programs receptor tumorigenesis

项目摘要

The following projects have been supported by Mouse Metabolism Core Laboratory in FY 2014 1. DK031131 Role of muscarinic acetylcholine receptors in glucose and energy homeostasis Principal Investigator: Jurgen Wess (LBC, NIDDK) 2. DK043313 Role of the Gnas Gene in Metabolic Regulation Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 3. DK043315 Role of Gs-alpha in central regulation of energy and glucose metabolism Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 4. DK043316 Role of Gs-alpha in regulation of adipose tissue growth and function Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 5. DK025102 Erythropoietin receptor and glucose metabolism Principal Investigator: Constance T Noguchi (MCB, NIDDK) 6. DK075004 Identification of novel molecules and pathways that modulate adipogenesis Principal Investigator: Elisabetta Mueller (GDDB, NIDDK) 7. DK075003 Regulation of PPARgamma expression and adipogenesis by PTIP-associated factors Principal Investigator: Kai Ge (NRB, NIDDK) 8. DK075017 Epigenetic regulation of adipogenesis. Principal Investigator: Kai Ge (NRB, NIDDK) 9. DK031116 Development of P2Y receptor ligands Principal Investigator: Kenneth A Jacobson (MR, NIDDK) 10. DK060101 Targeted disruption the enzymes of O-GlcNAc cycling: animal models of disease Principal Investigator: John A Hanover (LCMB, NIDDK) 11. DK075057 DEOB Physiology and Pharmacology of BRS-3 (Bombesin Receptor Subtype-3) Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 12. DK075063 DEOB What can body temperature tell us about energy homeostasis? Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 13. DK075064 DEOB Role of brown adipose tissue (BAT) in energy balance Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 14. DK061000 LGP Genetic Approaches to Understanding Organ Development and Function Principal Investigator: Lothar Hennighausen (LGP, NIDDK) 15. DK056018-06 (2012) Sphingolipid Biology and Regulation of Metabolism Principal Investigator: Richard L Proia (GDDB, NIDDK) 16. DK056014 Mouse Models of Novel Sphingolipid Biology and Disease Principal Investigator: Richard L Proia (GDDB, NIDDK) 17. DK036150 Organization and regulation of the human insulin locus Principal Investigator: Gary Felsenfeld (LMB, NIDDK) 18. DK075035 Genes associated with endocrine tumorigenesis Principal Investigator: Sunita K Agarwal (MDB, NIDDK) 19. DK055106 Transforming growth factor - beta superfamily signaling in diabetes and obesity Principal Investigator: Sushil Rane (DB, NIDDK) 20. DK055107 Cell cycle regulators in diabetes and obesity Principal Investigator: Sushil Rane (DB, NIDDK) 21. BC005708 Xenobiotic receptors Principal Investigator: Frank J Gonzalez (LM, NCI) 22. HD000641 Physiology, psychology, and genetics of obesity Principal Investigator: Jack Adam Yanovski (UGO, NICHD) 23. HD000642 Molecular Genetics of Adrenocortical Tumors And Related Disorders Principal Investigator: Constantine A Stratakis (PDEG, NICHD)

2014财年小鼠代谢核心实验室资助以下项目 1.DK031131 毒蕈碱乙酰胆碱受体在葡萄糖和能量稳态中的作用首席研究员：Jurgen Wess（LBC、NIDDK） 2.DK043313 Gnas 基因在代谢调节中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 3.DK043315 Gs-α 在能量和葡萄糖代谢中枢调节中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 4.DK043316 Gs-α 在调节脂肪组织生长和功能中的作用首席研究员：Lee S. Weinstein（MDB、NIDDK） 5.DK025102 促红细胞生成素受体与葡萄糖代谢首席研究员：Constance T Noguchi（MCB、NIDDK） 6.DK075004 鉴定调节脂肪生成的新分子和途径首席研究员：Elisabetta Mueller（GDDB、NIDDK） 7.DK075003 PTIP 相关因子对 PPARgamma 表达和脂肪生成的调节首席研究员：葛凯（NRB、NIDDK） 8.DK075017 脂肪生成的表观遗传调控。首席研究员：葛凯（NRB、NIDDK） 9.DK031116 P2Y受体配体的开发首席研究员：Kenneth A Jacobson（MR，NIDDK） 10.DK060101 靶向破坏 O-GlcNAc 循环酶：疾病动物模型首席研究员：John A Hanover（LCMB、NIDDK） 11. DK075057 德奥布 BRS-3（铃蟾肽受体亚型 3）的生理学和药理学首席研究员：Marc L. Reitman（DEOB、NIDDK） 12. DK075063 德奥布体温可以告诉我们关于能量稳态的什么信息？首席研究员：Mark L. Reitman（DEOB、NIDDK） 13. DK075064 德奥布棕色脂肪组织（BAT）在能量平衡中的作用首席研究员：Mark L. Reitman（DEOB、NIDDK） 14.DK061000导光板了解器官发育和功能的遗传学方法首席研究员：Lothar Hennighausen（LGP、NIDDK） 15.DK056018-06 (2012) 鞘脂生物学和代谢调节首席研究员：Richard L Proia（GDDB、NIDDK） 16.DK056014 新型鞘脂生物学和疾病的小鼠模型首席研究员：Richard L Proia（GDDB、NIDDK） 17.DK036150 人胰岛素基因座的组织和调节首席研究员：Gary Felsenfeld（LMB，NIDDK） 18.DK075035 与内分泌肿瘤发生相关的基因首席研究员：Sunita K Agarwal（MDB、NIDDK） 19.DK055106 糖尿病和肥胖症中的转化生长因子 - β 超家族信号传导首席研究员：Sushil Rane（DB、NIDDK） 20.DK055107 糖尿病和肥胖症中的细胞周期调节剂首席研究员：Sushil Rane（DB、NIDDK） 21.BC005708 异生素受体首席研究员：Frank J Gonzalez（LM，NCI） 22.HD000641 肥胖的生理学、心理学和遗传学首席研究员：Jack Adam Yanovski（UGO、NICHD） 23.HD000642 肾上腺皮质肿瘤及相关疾病的分子遗传学首席研究员：Constantine A Stratakis（PDEG、NICHD）