Autophagy and Neurodegeneration: Mechanisms to Therapies

自噬和神经退行性变：治疗机制

• 批准号: 10608666
• 负责人: Thale Cross Jarvis
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608666
• 关键词: Address; Area; Autophagocytosis; Biological; Biological Markers; Biological Process; Biology; Brain; Cell physiology; Cells; Clinical; Collaborations; Communities; Dedications; Development; Disease; Educational workshop; Etiology; Evolution; Feedback; Functional disorder; Goals; Health; Homeostasis; Human; Industrialization; Industry; Knowledge; Learning; Methodology; Molecular; Monitor; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Organism; Outcome; Pathogenesis; Pathway interactions; Process; Regulation; Research; Research Personnel; Role; Scientist; Stress; Technology; Therapeutic; Translations; Utah; Work; bench to bedside; clinical practice; clinical translation; design; human disease; improved; innovation; interest; multidisciplinary; next generation; novel; pharmacologic; posters; pre-clinical; preclinical study; programs; symposium; translational medicine; translational therapeutics; treatment response

ABSTRACT Support is requested for a Keystone Symposia conference entitled Autophagy and Neurodegeneration: Mechanisms to Therapies, organized by Drs. Ralph Nixon, Ana Maria Cuervo and Gilbert Di Paolo. The conference will be held in Snowbird, Utah from March 26-29, 2023. Autophagy is an essential cellular process required for cellular homeostasis and adaptation to stress. Autophagy malfunction is a common mechanism in the pathogenesis of multiple human diseases including neurodegenerative conditions. The autophagy field has now matured to support expanding initiatives aimed at targeting autophagy with therapeutic purpose. This Keystone Symposia conference will highlight the field’s evolution from an exclusively molecular cell biological focus to one that now also addresses expanding biological functions and etiological roles in specific neurodegenerative disease states. The program will also offer initial glimpses of promising clinical translation originating from surging industry interest in autophagy modulation as therapy in the field of neurodegeneration. This program is designed to be particularly innovative as the goal was to capture the bench to bedside scope of autophagy research by featuring new findings from a multidisciplinary panel of academic and industry speakers with a combination of conceptual themes spanning from basic biology of neuronal and glial autophagy to translational medicine and therapeutics. Appreciation of the brain’s special vulnerabilities to autophagy dysfunction has grown in the research community. Additionally, there are promising therapeutic responses to autophagy modulation in major neurodegenerative disorders that are emerging from preclinical studies, which is a novel concept to address at this conference. Finally, there are two workshops being developed that will address critical knowledge gaps in the clinical translation of autophagy fundamental: “Integrated Modulation of Organism Autophagy” and “Monitoring Autophagy: Biomarkers and Disease-Precision “Omics.” The informal workshop setting will encourage audience participation along with providing an avenue to brainstorm ideas in these emerging areas.

抽象的 请求支持Keystone研讨会会议标题为“自噬和神经变性： 由Drs组织的疗法机制。拉尔夫·尼克松，安娜·玛丽亚·库尔沃和吉尔伯特·迪·保罗。这 会议将于2023年3月26日至29日在犹他州雪鸟举行。 自噬是细胞稳态和适应压力所需的必不可少的细胞过程。 自噬故障是多种人类疾病的发病机理，包括 神经退行性条件。自噬领域现在已经成熟，以支持针对的扩展计划 针对治疗目的靶向自噬。这次Keystone研讨会会议将重点介绍该领域的 从专门的分子细胞生物学焦点到现在也解决扩展的进化 在特定神经退行性疾病状态中的生物学功能和病因作用。该程序也将 提供有前途的临床翻译的初始瞥见，该翻译源于产业对自噬的兴趣 调节作为神经退行性领域的治疗。该计划旨在特别创新 目的是通过展示来自 具有概念主题的学术和行业演讲者的多学科小组 从神经元和神经胶质自噬的基本生物学到转化医学和治疗。赞赏 大脑在研究界的自动功能障碍的特殊脆弱性已经增长。此外， 有望在主要神经退行性疾病中对自噬调节的治疗反应， 是从临床前研究中出现的，这是在本次会议上解决的一个新颖概念。最后，有 开发了两个研讨会，这些讲习班将解决临床翻译中的关键知识差距 自噬基本：“有机体自噬的综合调制”和“监测自噬： 生物标志物和疾病过度的“ OMICS”。非正式的研讨会环境将鼓励观众 参与以及在这些新兴地区提供集思广益思想的途径。