Small Regulatory RNAs: From Bench to Bedside

小调控 RNA：从实验室到临床

• 批准号: 10462420
• 负责人: Thale Cross Jarvis
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-27 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462420
• 关键词: Academia; Address; Area; Biological Process; Biology; Biotechnology; Clinic; Clinical; Collaborations; Development; Diagnosis; Disease; Educational workshop; Environment; Fibrosis; Future; Gene Expression; Goals; Hepatitis; Homeostasis; Industry; Kidney Diseases; Knowledge; Mentors; Methodology; MicroRNAs; Mind; Molecular; New Mexico; Oncology; Outcome; Pharmacologic Substance; Physicians; Play; Postdoctoral Fellow; Process; Property; RNA; RNA-targeting therapy; Regulator Genes; Research; Research Personnel; Role; Science; Scientist; Small Interfering RNA; Small RNA; Students; Technology; Therapeutic; Therapeutic Agents; Therapeutic Uses; Translations; base; bench to bedside; bench-to-bedside translation; career; clinical practice; design; fight against; human disease; interest; invention; meetings; new therapeutic target; novel therapeutics; posters; programs; rare genetic disorder; symposium; targeted treatment; therapeutic RNA; tool; wound healing; Academia; Address; Area; Biological Process; Biology; Biotechnology; Clinic; Clinical; Collaborations; Development; Diagnosis; Disease; Educational workshop; Environment; Fibrosis; Future; Gene Expression; Goals; Hepatitis; Homeostasis; Industry; Kidney Diseases; Knowledge; Mentors; Methodology; MicroRNAs; Mind; Molecular; New Mexico; Oncology; Outcome; Pharmacologic Substance; Physicians; Play; Postdoctoral Fellow; Process; Property; RNA; RNA-targeting therapy; Regulator Genes; Research; Research Personnel; Role; Science; Scientist; Small Interfering RNA; Small RNA; Students; Technology; Therapeutic; Therapeutic Agents; Therapeutic Uses; Translations; base; bench to bedside; bench-to-bedside translation; career; clinical practice; design; fight against; human disease; interest; invention; meetings; new therapeutic target; novel therapeutics; posters; programs; rare genetic disorder; symposium; targeted treatment; therapeutic RNA; tool; wound healing

ABSTRACT Support is requested for a Keystone Symposia conference entitled Small Regulatory RNAs: From Bench to Bedside, organized by Drs. Frank Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt. The conference will be held in Santa Fe, New Mexico from May 1-4, 2022. RNA-based therapeutics are already approved for a variety of human diseases. A large and diverse set of small regulatory RNAs have emerged as key regulators of gene expression during development and cellular homeostasis and are frequently mis-expressed in human disease. Their small size and molecular properties make small RNAs amenable as targets and therapeutics and provide physicians with a powerful new battery of agents to diagnose and treat disease. However, while thousands of small RNAs are known, relatively little is known about their roles and targets, and there is still a limited application of these molecules in the clinic. This conference program is designed to explore the exciting biology of small regulatory RNAs and to highlight the best current research into the role that small RNAs play in fundamental processes. Additionally, other sessions will focus on the latest efforts to harness the power of these RNAs as agents in the fight against disease and provide the basic understanding that will drive the invention of powerful clinical tools. Dedicated sessions will focus on therapeutic applications of microRNA and siRNA in areas of high interest such as oncology, as well as diverse conditions ranging from rare genetic disorders to kidney disease, fibrosis, hepatitis and wound healing. It is anticipated that this conference will attract the many researchers working in small RNAs to come together to engage in critical discussions that will advance the field and accelerate the bench to bedside translation of this technology. Finally, this conference will provide a stimulating environment where students, postdocs and junior investigators can present and discuss their research with the best minds in the field.

抽象的 请求支持Keystone研讨会会议，标题为“小监管RNA：从长凳到 床边，由Drs组织。弗兰克·斯洛克（Frank Slack），约尔格·沃格尔（JörgVogel），伊万·马丁内斯（Ivan Martinez）和卡琳·施密特（Karyn Schmidt）。会议将是 2022年5月1日至4日在新墨西哥州圣达菲举行。 基于RNA的治疗已经被批准用于各种人类疾病。一组大而多样的 小调节性RNA已成为发育和细胞期间基因表达的关键调节剂 体内平衡，经常在人类疾病中表达。它们的尺寸小和分子特性 使小型RNA作为目标和疗法，并为医生提供强大的新电池 诊断和治疗疾病的药物。但是，尽管已知成千上万的小RNA，但相对较少 知道它们的作用和目标，并且这些分子在诊所中仍然存在有限的应用。这 会议计划旨在探讨小型监管RNA的激动人心的生物学，并突出显示 最佳目前研究小型RNA在基本过程中所扮演的角色。另外，其他 会议将集中于最新的努力，以利用这些RNA作为对抗的代理商的力量 疾病并提供基本的理解，以推动强大的临床工具的事故。投入的 会议将重点介绍microRNA和siRNA在高感兴趣领域的治疗应用，例如 肿瘤学以及从罕见的遗传疾病到肾脏疾病，纤维化，肝炎 和伤口愈合。预计这次会议将吸引许多小型研究人员 RNA聚集在一起，进行批判性讨论，以推进该领域并加速替补席 该技术的床头翻译。最后，这次会议将提供一个令人兴奋的环境 学生，博士后和初级调查人员可以与最好的思想一起介绍和讨论他们的研究 场地。