Small Regulatory RNAs: From Bench to Bedside

小调控 RNA：从实验室到临床

基本信息

批准号：
10462420
负责人：
Thale Cross Jarvis
金额：
$ 0.5万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-27 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10462420
关键词：
Academia Address Area Biological Process Biology Biotechnology Clinic Clinical Collaborations Development Diagnosis Disease Educational workshop Environment Fibrosis Future Gene Expression Goals Hepatitis Homeostasis Industry Kidney Diseases Knowledge Mentors Methodology MicroRNAs Mind Molecular New Mexico Oncology Outcome Pharmacologic Substance Physicians Play Postdoctoral Fellow Process Property RNA RNA-targeting therapy Regulator Genes Research Research Personnel Role Science Scientist Small Interfering RNA Small RNA Students Technology Therapeutic Therapeutic Agents Therapeutic Uses Translations base bench to bedside bench-to-bedside translation career clinical practice design fight against human disease interest invention meetings new therapeutic target novel therapeutics posters programs rare genetic disorder symposium targeted treatment therapeutic RNA tool wound healing

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Small Regulatory RNAs: From Bench to Bedside, organized by Drs. Frank Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt. The conference will be held in Santa Fe, New Mexico from May 1-4, 2022. RNA-based therapeutics are already approved for a variety of human diseases. A large and diverse set of small regulatory RNAs have emerged as key regulators of gene expression during development and cellular homeostasis and are frequently mis-expressed in human disease. Their small size and molecular properties make small RNAs amenable as targets and therapeutics and provide physicians with a powerful new battery of agents to diagnose and treat disease. However, while thousands of small RNAs are known, relatively little is known about their roles and targets, and there is still a limited application of these molecules in the clinic. This conference program is designed to explore the exciting biology of small regulatory RNAs and to highlight the best current research into the role that small RNAs play in fundamental processes. Additionally, other sessions will focus on the latest efforts to harness the power of these RNAs as agents in the fight against disease and provide the basic understanding that will drive the invention of powerful clinical tools. Dedicated sessions will focus on therapeutic applications of microRNA and siRNA in areas of high interest such as oncology, as well as diverse conditions ranging from rare genetic disorders to kidney disease, fibrosis, hepatitis and wound healing. It is anticipated that this conference will attract the many researchers working in small RNAs to come together to engage in critical discussions that will advance the field and accelerate the bench to bedside translation of this technology. Finally, this conference will provide a stimulating environment where students, postdocs and junior investigators can present and discuss their research with the best minds in the field.

抽象的请求支持题为“小型监管 RNA：从实验室到 Bedside，由 Frank Slack 博士、Jörg Vogel、Ivan Martinez 和 Karyn Schmidt 组织。 2022 年 5 月 1 日至 4 日在新墨西哥州圣达菲举行。基于 RNA 的疗法已被批准用于治疗多种人类疾病。小调节RNA已成为发育和细胞过程中基因表达的关键调节因子它们的小尺寸和分子特性经常在人类疾病中被错误表达。使小 RNA 适合作为靶点和治疗方法，并为医生提供了强大的新电池然而，虽然已知有数千种小RNA，但了解的相对较少。人们已经了解它们的作用和靶点，并且这些分子在临床上的应用仍然有限。会议议程旨在探索小调控RNA令人兴奋的生物学并强调目前关于小 RNA 在基本过程中的作用的最佳研究。会议将重点关注利用这些RNA作为抗击新冠病毒的力量的最新努力疾病并提供基本的了解，从而推动强大的临床工具的发明。会议将重点关注 microRNA 和 siRNA 在人们高度关注的领域的治疗应用，例如肿瘤学，以及从罕见遗传性疾病到肾脏疾病、纤维化、肝炎等多种疾病预计这次会议将吸引许多小型研究人员。 RNA 齐聚一堂，进行批判性讨论，这将推动该领域的发展并加速实验室的发展最后，本次会议将为这项技术提供一个令人兴奋的环境。学生、博士后和初级研究人员可以与业内最优秀的人一起展示和讨论他们的研究场地。