Adipose Tissue: Energizing Good Fat

脂肪组织：为好脂肪提供能量

• 批准号: 10609127
• 负责人: Thale Cross Jarvis
• 金额: $ 2.02万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609127
• 关键词: Address; Adipocytes; Adipose tissue; Affect; Area; Bioenergetics; Biology; Cardiometabolic Disease; Cardiovascular Diseases; Cells; Collaborations; Colorado; Consensus; Development; Disease; Eating; Economics; Educational workshop; Elements; Ethics; Fatty acid glycerol esters; Focus Groups; Functional disorder; Future; Goals; Health; Homeostasis; Human; Immune; Joints; Knowledge; Lipids; Mediator; Medicine; Mentors; Metabolic; Metabolic Diseases; Metabolism; Methodology; Mitochondria; Molecular; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Physiological; Play; Rana; Research; Research Personnel; Role; Underrepresented Populations; Vision; Work; career development; clinical practice; design; health disparity; health inequalities; human disease; improved; interest; metabolic rate; mortality; nerve supply; next generation; non-alcoholic fatty liver disease; novel therapeutics; posters; programs; stem cells; symposium; synergism; tissue repair; translational potential

ABSTRACT Support is requested for a Keystone Symposia conference entitled Adipose Tissue: Energizing Good Fat, organized by Drs. Silvia Corvera, Kendra Bence and Rana Gupta. The conference will be held in Keystone, Colorado from January 15-19, 2023. Adipose tissue plays a critical role in metabolic health. Having a better understanding of its biology will guide development of new therapeutics for metabolic diseases. Therefore, this conference was developed to address key emerging questions in the field, from physiological to molecular, in order to facilitate synergy between established groups while also providing new trainees with a better picture of critical knowledge gaps. Key questions to be covered include: How do different adipose tissue depots contribute to systemic metabolism? How many types of adipocytes exist, and how do they contribute to the functions of different depots? How do adipocytes develop from progenitor cells? How do elements such as immune cells, vasculature and innervation influence their development? And finally, how do adipocyte lipid droplets and mitochondria develop, function and influence systemic metabolic homeostasis? There will also be discussions on how to envision research on adipose tissue in relation to the broader topic of human health. Adipose tissue disfunction, as manifested by obesity and metabolic disease, disproportionally affects groups underrepresented in medicine and research. Therefore, this health inequity will be addressed through a keynote address as well as a health disparities workshop. This program will also include a career development workshop for trainees. Finally, this conference will be paired with the Keystone Symposia conference on Bioenergetics in Health and Diseases. In order to help stimulate networking opportunities and develop new collaborations, there have been three joint sessions designed for these conferences: Metabolic Flux in Health and Disease, Bioenergetics and Energy Homeostasis, and Adipose Tissue and Metabolic Diseases.

抽象的 请求支持Keystone研讨会会议，标题为“脂肪组织：良好的脂肪”， 由Drs组织。 Silvia Corvera，Kendra Bence和Rana Gupta。会议将在基斯通举行 科罗拉多州，从2023年1月15日至19日。 脂肪组织在代谢健康中起关键作用。对其生物学有更好的了解将指导 开发用于代谢疾病的新疗法。因此，这次会议是发展到 为了促进协同作用，解决从生理到分子的现场关键问题 在成熟的群体之间，同时还为新学员提供了更好的批判知识差距。 要涵盖的关键问题包括：不同的脂肪组织库如何有助于系统性 代谢？存在多少种类型的脂肪细胞，它们如何促进不同的功能 仓库？祖细胞如何从祖细胞中发展？免疫细胞等元素如何 脉管系统和神经影响会影响他们的发展？最后，脂肪细胞脂质液滴和如何 线粒体发展，功能和影响系统性代谢稳态？还将讨论 关于如何设想与更广泛的人类健康有关的脂肪组织的研究。脂肪组织 肥胖和代谢疾病所表现出的失功能不成比例地影响群体 医学和研究的代表性不足。因此，这种健康不平等将通过 主题演讲以及健康差异研讨会。该计划还将包括职业发展 学员的研讨会。最后，这次会议将与Keystone研讨会会议结合 健康和疾病中的生物能学。为了帮助刺激网络机会并发展新的机会 合作，为这些会议设计了三个联合会议：健康的代谢通报 和疾病，生物能和能量稳态以及脂肪组织和代谢疾病。