Gut-Brain Axis

肠脑轴

• 批准号: 10467819
• 负责人: Thale Cross Jarvis
• 金额: $ 1.72万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467819
• 关键词: Academia; Area; Autonomic nervous system; Behavior; Canada; Central Nervous System Diseases; Collaborations; Communication; Desire for food; Disease; Educational workshop; Endocrine; Enteric Nervous System; Future; Gastrointestinal tract structure; Health; Human; Immune; Immune System Diseases; Immune signaling; Immunity; Immunologist; Industry; Inflammation; Investments; Knowledge; Learning; Mediating; Mentors; Metabolic; Metabolic Diseases; Metabolic Pathway; Methodology; Neuraxis; Neurons; Obesity; Outcome; Participant; Pathway interactions; Physiology; Research; Research Personnel; Role; Scientist; System; Technology; Translations; Vagus nerve structure; Work; career; clinical implementation; clinical practice; gastrointestinal; gut-brain axis; hormonal signals; improved; interest; meetings; microbiome; nervous system disorder; neurobiological mechanism; neuropsychiatric disorder; nonalcoholic steatohepatitis; novel strategies; posters; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Gut-Brain Axis, organized by Drs. Ann Weber, Sarkis Mazmanian and Scott Sternson. The conference will be held in Banff, Canada from March 20- 23, 2022. The gut-brain axis encompasses bidirectional communication between the gastrointestinal tract and the central nervous system (CNS). This is mediated via the autonomic nervous system, including the vagus nerve and enteric nervous system (ENS), and endocrine, immune, and metabolic pathways. These systems coordinate physiology and behavior in health and disease. The underlying mechanisms and pathways are now being elucidated in this emerging area of scientific interest. Understanding the gut-brain axis augments neurobiological mechanisms and provides opportunities to treat CNS disorders from the periphery as well as metabolic and immunologic diseases, including diverse conditions ranging from obesity to nonalcoholic steatohepatitis to neurologic and neuropsychiatric disorders. This meeting will bring together basic and applied scientists from across academia and industry to advance our understanding of gut-brain signaling. By highlighting the latest research across the components of the gut-brain axis, including vagal and ENS circuits and gut hormone and immune signaling, the role of the microbiome, and the gut-brain axis in health and disease, this meeting will catalyze increased interest, investment and cross-disciplinary collaborations to advance promising new approaches to improving human health. Finally, this meeting is being paired with the Keystone Symposia conference, Neuronal Control of Appetite. The meetings will share sessions and provide an optimal venue for participants across both conferences to interact and develop new collaborations in these fields.

抽象的 请求支持由Drs组织的Keystone研讨会会议，名为“肠脑轴”。安 韦伯，萨基斯·马兹马尼亚人和斯科特·斯特恩森。该会议将于3月20日在加拿大班夫举行。 23，2022。 肠道轴包括胃肠道和中央之间的双向通信 神经系统（CNS）。这是通过自主神经系统介导的，包括迷走神经和 肠神经系统（ENS）以及内分泌，免疫和代谢途径。这些系统坐标 健康与疾病的生理和行为。现在的基本机制和途径正在 在这个科学意义的新兴领域阐明了。了解肠道轴的增加 神经生物学机制，并提供了治疗外围CNS疾病的机会 代谢和免疫疾病，包括从肥胖到非酒精性的各种疾病 神经系统和神经精神疾病的脂肪性肝炎。这次会议将汇集基础和应用 来自学术界和行业的科学家，以促进我们对肠道信号传导的理解。经过 强调肠道轴各个组件的最新研究，包括迷走和ENS电路 以及肠道激素和免疫信号传导，微生物组的作用以及肠道轴在健康和 疾病，这次会议将促进增加的兴趣，投资和跨学科合作 提高了有望改善人类健康的新方法。最后，这次会议与 Keystone研讨会会议，食欲的神经元控制。会议将分享会议并提供 两个会议的参与者的最佳场所，可以在这些会议中进行互动和发展新的合作 字段。