Drug Delivery to the Brain: Challenges and Progress

大脑药物输送：挑战与进展

• 批准号: 10540503
• 负责人: Thale Cross Jarvis
• 金额: $ 1.77万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540503
• 关键词: Academia; Address; Alzheimer' s Disease; Area; Biochemical; Biology; Blood; Blood - brain barrier anatomy; Blood Vessels; Brain; Career Choice; Central Nervous System Agents; Central Nervous System Diseases; Cerebrospinal Fluid; Cerebrovascular system; Clinical Research; Collaborations; Colorado; Development; Disease; Drug Delivery Systems; Educational workshop; Engineering; Event; Fostering; Future; Genetic; Goals; Health; Industry; Intention; International; Knowledge; Learning; Medical; Methodology; Methods; Neuraxis; Neurosciences; Oligonucleotides; Oral; Outcome; Parkinson Disease; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; Physiology; Postdoctoral Fellow; Proteins; Research; Research Personnel; Science; Scientist; Students; Technology; Time; Tissues; Work; bench to bedside; career; clinical practice; design; diversity and inclusion; drug development; gene therapy; improved; innovation; learning network; meetings; multidisciplinary; neurosurgery; next generation; novel; novel strategies; posters; pre-clinical research; research study; small molecule; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Drug Delivery to the Brain: Challenges and Progress, organized by Drs. Robert Thorne and Reina Bendayan. The conference will be held in Breckenridge, Colorado from January 26-39, 2023. This Keystone Symposia conference is designed to address the urgent scientific need for innovative, new approaches to central nervous system (CNS) drug delivery. Indeed, the current shortage of disease-modifying treatments for Alzheimer’s, Parkinson’s and other CNS diseases represent among the most significant unmet health needs of our time. Our ability to effectively tap into the vast potential that protein, oligonucleotide, and gene therapies have for treating CNS disorders has been sharply limited by the typically insufficient brain exposure that results after their systemic or central administration. Even many orally administered small molecules suffer from brain exposure limitations. Among the primary reasons for these limitations are the physical and biochemical barriers that exist at key CNS interfaces, including the blood-brain barrier at the level of the cerebrovasculature, other specialized barriers between the blood and cerebrospinal fluid, and further obstacles hindering drug exchange between cerebrospinal fluid and CNS tissue. CNS drug delivery research lies at the crossroads between many different fields, including physiology, pharmacology, pharmaceutical science, neuroscience, neurosurgery, engineering, genetics, and vascular biology, among others. Surprisingly few conferences to date have focused exclusively on the multidisciplinary challenges associated with CNS drug delivery. The goals of this symposium are (i) to bring together international experts and junior investigators from multiple research fields for the purpose of exchanging new ideas and brainstorming novel solutions to existing CNS drug delivery challenges and (ii) to highlight new methods and perspectives with the potential to change how CNS drug delivery research studies are performed and, ultimately, to transform the field. Sessions are to include a number of short talks chosen to integrate late-breaking developments and new research directions from the field.

抽象的 请求支持Keystone研讨会会议，标题为“向大脑交付药物：挑战和 进度，由Drs组织。罗伯特·索恩（Robert Thorne）和雷纳·本田（Reina Bendayan）。会议将在 科罗拉多州布雷肯里奇，2023年1月26日至39日。 这次Keystone研讨会会议旨在满足新创新的紧急科学需求 中枢神经系统（CNS）药物输送的方法。确实，当前的疾病改良短缺 对阿尔茨海默氏症，帕金森氏症和其他中枢神经系统疾病的治疗 我们时间的健康需求。我们有效利用蛋白质，寡核苷酸和 基因疗法对治疗中枢神经系统疾病的治疗已受到通常不足的大脑的严格限制 在其系统或中央给药后导致的暴露。甚至许多口服的小 分子受到大脑暴露的限制。这些限制的主要原因之一是 在关键CNS界面上存在的物理和生化障碍，包括该水平的血脑屏障 在脑血管造期，血液和脑脊液之间的其他专门障碍，进一步 阻碍脑脊液和中枢神经系统组织之间的药物交换的障碍。 CNS药物输送研究 位于许多不同领域之间的十字路口，包括生理学，药理学，药物 科学，神经科学，神经外科，工程，遗传学和血管生物学等。出奇 迄今为止，很少有会议仅专注于与CNS相关的多学科挑战 药物输送。该研讨会的目标是（i）汇集国际专家和初中 来自多个研究领域的研究人员，目的是交换新思想和集思广益的小说 现有CNS药物输送挑战的解决方案，以及（ii），以强调新方法和观点 改变CNS药物输送研究的潜力，并最终改变 场地。会议将包括许多简短的演讲，以整合后期的发展和新的发展 研究方向。