2023 Neurotrophic Mechanisms in Health and Disease

2023 健康与疾病中的神经营养机制

• 批准号: 10654336
• 负责人: Rejji Kuruvilla
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10654336
• 关键词: Academia; Acceleration; Address; Adoption; Adult; Affect; Alzheimer' s Disease; Area; Award; Axon; Basic Science; Behavior; Biology; Breast Feeding; COVID-19; Cells; Cellular biology; Child Care; Chronic; Clinical; Clinical Trials; Collaborations; Communication; Communities; Computing Methodologies; Dedications; Dendrites; Development; Disease; Environment; Family; Fostering; Friends; Funding; Goals; Growth; Growth Factor; Health; Human; Immune signaling; Industry; Infant Care; Inflammation; Knowledge; Maintenance; Malignant Neoplasms; Mental Depression; Mental disorders; Methodology; Methods; Molecular; Natural regeneration; Nervous System; Nervous System Physiology; Neurodegenerative Disorders; Neuroglia; Neurologic; Neurons; Neurosciences; Ointments; Pathology; Pediatric Neoplasm; Physiology; Postdoctoral Fellow; Privatization; Reagent; Recording of previous events; Regulation; Research; Research Personnel; Role; Schedule; Scientist; Signal Transduction; Site; Students; Synaptic plasticity; System; Systems Biology; Therapeutic; Time; Translating; Translations; Travel; Underrepresented Populations; Universities; Woman; Work; career; childcare allowance; chronic pain; cohort; community-level factor; developmental disease; diversity and inclusion; faculty mentor; insight; interest; meetings; multidisciplinary; myelination; nervous system development; nervous system disorder; neurogenesis; neuron development; neuron loss; neuronal survival; neurotrophic factor; novel strategies; optogenetics; programs; recruit; repaired; stem cell biology; stem cell niche; stem cells; symposium; tissue regeneration; tissue repair; tool; translational applications; translational medicine; tumor progression; virtual

Abstract This proposal is to provide support for early career investigators, post-doctoral fellows, and students to attend the Gordon Research Conference (GRC) on Neurotrophic Mechanisms in Health and Disease and the accompanying Gordon Research Seminar (GRS). The GRC will be held in Salve Regina University Newport RI from May 28-June 2 2023, and the GRS on May 27-28. Neurotrophic factors, broadly defined as factors that have critical roles in circuit connectivity, synaptic plasticity, and behavior, are essential for the development, maintenance, repair, and functions of the nervous system. Importantly, several treatments that exploit knowledge of neurotrophin biology are now in human clinical trials for chronic pain, Alzheimer's disease, and cancer. This GRC is the primary forum for bringing together diverse communities of basic researchers and clinicians investigating growth factor biology in the nervous system. The 2023 Neurotrophic Mechanisms in Health and Disease GRC is unique in bringing together a multi- disciplinary group of researchers in areas spanning fundamental problems in molecular, cellular, and developmental neuroscience to translating neurotrophin biology into therapies. The meeting will provide an important venue to integrate basic research on neurotrophic factor biology with clinical needs and industry interest, with the ultimate goal of accelerating the development and adoption of new treatments for human neurodevelopmental and neurological conditions, psychiatric diseases, and some forms of cancers. The conference will bring together speakers, many new to the meeting, who will speak to the intersection of neurotrophin biology with circuit formation, neuron-glia/immune signaling, stem cell biology, chronic pain, depression, tissue repair, and neurological disorders. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers. Several features distinguish the 2023 GRC Neurotrophic Factor conference from earlier meetings. These include an emphasis on the intersection of neurotrophin biology with neuron-glia/immune signaling, stem cells, tissue repair, and therapeutic avenues, recruitment of a cohort of investigators new to the meeting who will speak to these emerging areas and provide fresh perspectives, robust representation of speakers who are women (57.1%), and from historically under-represented groups in academia (20%), introduction of an associated two- day GRS for students and postdoctoral scientists to facilitate networking among junior scientists, and introduction of a faculty mentoring system for junior trainees.

抽象的 该建议是为早期职业调查人员，博士后研究员和学生提供支持 参加有关健康和疾病的神经营养机制的戈登研究会议（GRC） 伴随戈登研究研讨会（GRS）。 GRC将在Regina University Newport RI举行 从5月28日至6月2日至2023年，以及5月27日至28日的GRS。神经营养因素，广泛定义为 在电路连通性，突触可塑性和行为中具有关键作用，对于开发至关重要， 神经系统的维护，修复和功能。重要的是，利用知识的几种治疗方法 神经营养生物学的生物学目前正在为慢性疼痛，阿尔茨海默氏病和癌症的人类临床试验中。这 GRC是将基础研究人员和临床医生组成的不同社区聚集在一起的主要论坛 研究神经系统中生长因子生物学。 2023年健康和疾病GRC中的神经营养机制在整合多个 纪律研究人员的研究人员在分子，细胞和 发育神经科学将神经营养生物学转化为疗法。会议将提供 将神经营养因素生物学与临床需求和行业相结合的基础研究的重要场所 兴趣，最终的目标是加速人类的开发和采用新治疗 神经发育和神经系统疾病，精神疾病以及某些形式的癌症。这 会议将聚集在一起，会议的许多新演讲者，他们将在 神经营养蛋白生物学，有回路形成，神经元-GLIA/免疫信号传导，干细胞生物学，慢性疼痛， 抑郁，组织修复和神经系统疾病。其他主题和后期的发展将是 通过从摘要中选出的会谈，特别鼓励初级研究人员参与。 几个功能将2023 GRC神经营养因素会议与早期会议区分开。这些 包括强调神经营养蛋白生物学与神经元/免疫信号传导，干细胞，，， 组织维修和治疗途径，招募了会议新的调查员 这些新兴领域并提供新的观点，强大的女性说话者的代表 （57.1％），以及从历史上代表性不足的学术界（20％）中引入相关的两种群体 学生和博士后科学家的日期，以促进初级科学家之间的网络，并引入 初级学员的教师指导系统。