Transposable Elements at the Crossroads of Evolution, Health and Disease

处于进化、健康和疾病十字路口的转座元件

• 批准号: 10750852
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-13 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10750852
• 关键词: Academia; Acceleration; Address; Affect; Aging; Area; Automobile Driving; Basic Science; Bioinformatics; Biological; Biology; Biomedical Research; British Columbia; Burn injury; Canada; Collaborations; DNA Transposable Elements; Development; Disease; Educational workshop; Elements; Environmental Science; Epigenetic Process; Evolution; Genome; Genome engineering; Genomics; Health; Human; Human Biology; Industry; International; Knowledge; Learning; Life; Methodology; Mobile Genetic Elements; Molecular; Nature; Nerve Degeneration; Organism; Outcome; Pathologic; Plants; Play; Population; Process; Property; Proteomics; Research; Research Personnel; Role; Scientist; Shapes; Technology; Time; Work; carcinogenesis; clinical practice; improved; insight; interest; next generation; posters; symposium; tool development; transposon/insertion element

ABSTRACT Support is requested for a Keystone Symposia conference entitled Transposable Elements at the Crossroads of Evolution, Health and Disease, organized by Drs. Kathleen Burns, Harmit Malik and Irina Arkhipova. The conference will be held in Whistler, British Columbia, Canada from September 3-6, 2023. Transposable elements are omnipresent in every domain of life and play an eminent role in shaping biological properties of living organisms. The field of transposon research has significantly expanded with the realization that mobile DNA constitutes a major component of most genomes and that transposable element sequences, while generally mutagenic, can be co-opted to benefit the host species. Moreover, rapid development of tools to study transposon activities enables the efforts to differentiate their causal and epiphenomenal effects. There is a pressing need to understand the many ways in which mobile DNA affects genome evolution and shapes its function under normal and pathological states. The aims of this conference are to: 1) Apply recent advances in genomics, proteomics and bioinformatics towards an overview of transposon integration into genomic compartments, epigenetic processes and regulatory networks over evolutionary time scales; 2) Expand structural and mechanistic insights into the nature of transposition processes affecting genome dynamics and integrity; 3) Close the gaps in understanding transposon mobilization and its control at the molecular, cellular, organismal, and population levels, highlighting the impact on carcinogenesis, neurodegeneration and aging; 4) Showcase the applications of fundamental knowledge on mobile element-host interactions to the burgeoning fields of genome engineering, biomedicine, plant and environmental sciences. Accelerating advances in the field will attract new investigators who will benefit greatly from this conference, while giving the long-standing experts reasons to reconvene, share methodologies, and promote new collaborations between leading international groups on the broadest possible scale, exploring all kingdoms of life.

抽象的 请求支持Keystone研讨会会议，标题为“ Crossroads” 由Drs组织的进化，健康和疾病。 Kathleen Burns，Harmit Malik和Irina Arkhipova。这 会议将于2023年9月3日至6日在加拿大不列颠哥伦比亚省的惠斯勒举行。 转座元素在生活的每个领域无处不在，并且在塑造生物学方面发挥着重要作用 活生物体的特性。随着实现的实现，转座子研究领域已大大扩展 该移动DNA构成了大多数基因组的主要组成部分，并且该转座元件序列， 虽然通常可以选择诱变，但可以使宿主物种受益。而且，工具的快速开发 研究转座子活性可以努力区分其因果和表现效应。那里 迫切需要了解移动DNA影响基因组进化并塑造其的多种方式 在正常状态和病理状态下的功能。这次会议的目的是：1）在 基因组学，蛋白质组学和生物信息学，概述转座子整合到基因组中 在进化时间尺度上的隔室，表观遗传过程和调节网络； 2）扩展 对影响基因组动力学和的换位过程性质的结构和机械洞察 正直; 3）缩小理解转座子动员及其对照在分子，细胞， 有机体和种群水平，强调了对癌变，神经退行性和衰老的影响； 4） 展示有关移动元素互动互动的基本知识在新兴的应用 基因组工程，生物医学，植物和环境科学领域。加速进步 领域将吸引新的调查员，他们将从本次会议中受益匪浅，同时为长期存在 专家的理由重新闻，共享方法和促进领先的新合作 国际团体最广泛的规模，探索了生活的所有王国。