Metastasis

转移

基本信息

批准号：
10681132
负责人：
TERRY L. SHEPPARD
金额：
$ 1.5万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-06 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10681132
关键词：
Address Area Biology Blood British Columbia Canada Cancer Burden Career Mobility Cause of Death Cell Survival Cells Clinical Management Collaborations DNA analysis Development Distant Metastasis Economic Burden Education Educational workshop Emotional Environment Epigenetic Process Event Evolution Future Genetic Goals Growth Image Industrialization Joints Knowledge Learning Malignant Neoplasms Metabolic Metabolism Methodology Modeling Nature Neoplasm Metastasis Outcome Phenotype Primary Neoplasm Process Proliferating Regulation Research Research Personnel Resistance Scientist Stress Work cancer cell cancer survival cancer therapy career circulating cancer cell clinical practice experience improved interest multidisciplinary novel strategies posters programs symposium therapeutic target treatment response tumor microenvironment

Address Area Biology Blood British Columbia Canada Cancer Burden Career Mobility Cause of Death Cell Survival Cells Clinical Management Collaborations DNA analysis Development Distant Metastasis Economic Burden Education Educational workshop Emotional Environment Epigenetic Process Event Evolution Future Genetic Goals Growth Image Industrialization Joints Knowledge Learning Malignant Neoplasms Metabolic Metabolism Methodology Modeling Nature Neoplasm Metastasis Outcome Phenotype Primary Neoplasm Process Proliferating Regulation Research Research Personnel Resistance Scientist Stress Work cancer cell cancer survival cancer therapy career circulating cancer cell clinical practice experience improved interest multidisciplinary novel strategies posters programs symposium therapeutic target treatment response tumor microenvironment

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项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Metastasis, organized by Drs. Joan Massagué, Sean Morrison and Caroline Dive. The conference will be held in Vancouver, British Columbia Canada from May 7- 10, 2023. Most cancer deaths are caused by distant metastasis, yet the mechanisms that regulate distant metastasis are poorly understood. Metastasis is a very inefficient process in which few disseminated cancer cells survive, and even fewer proliferate, but little is known about why. This conference will address the nature of metastasis initiating cells as well as their phenotypic plasticity, genetic and epigenetic evolution. Speakers will cover topics including the characterization of circulating cancer cells and how recent advances in imaging and DNA analysis are assisting the clinical management of metastasis. Other sessions will cover why cancer cells sometimes go dormant after metastasis. Additionally, the program will include sessions which will discuss the metabolic regulation of metastasis and how the metabolic environment influences the survival of cancer cells during metastasis. Finally, this conference is being paired with the Keystone Symposia conference entitled, The Resistant Tumor Microenvironment. There will be joint sessions and attendees of both conferences will be able to interact and network during mealtimes and poster sessions.

抽象的请求支持由Drs组织的Keystone研讨会会议，名为《转移》。琼 Massagué，Sean Morrison和Caroline Dive。会议将在不列颠哥伦比亚省温哥华举行加拿大从2023年5月7日至10日。大多数癌症死亡是由远处转移引起的，但是调节遥远转移的机制是理解不佳。转移是一个非常无效的过程，其中很少传播癌细胞存活，而甚至更少的扩散，但对原因知之甚少。这次会议将解决转移的性质引发细胞及其表型可塑性，遗传和表观遗传进化。演讲者将掩护主题包括表征循环癌细胞以及成像和DNA的最新进展分析有助于转移的临床管理。其他会议将涵盖为什么癌细胞有时转移后休眠。此外，该计划将包括会议，将讨论代谢调节转移以及代谢环境如何影响癌细胞的存活率在转移期间。最后，这次会议与Keystone研讨会会议配对，标题为“ 抗性肿瘤微环境。两个会议的联合会议和与会者将是它可以在进餐时间和海报会议期间进行互动和网络。