Infections in Pregnancy: PathogenicMechanisms, Experimental Advances and Clinical Strategies

妊娠期感染：致病机制、实验进展和临床策略

• 批准号: 10540260
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-04 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540260
• 关键词: 2019-nCoV; Biology; Child Health; Clinical; Clinical Research; Collaborations; Congenital Abnormality; Cytomegalovirus; Development; Developmental Delay Disorders; Diagnostic; Educational workshop; Fetal health; Fetus; Growth; Human; Immune; Immune response; Immunologics; Infant Health; Infection; Joints; Knowledge; Learning; Maternal Health; Maternal-Fetal Exchange; Methodology; Microbe; Modeling; New Mexico; Outcome; Participant; Pathogenesis; Pathogenicity; Patient Care; Patients; Penetration; Physiological; Placenta; Pregnancy; Reporting; Research; Research Design; Research Personnel; Streptococcus Group B; Structure; System; Therapeutic; Time; Toxoplasma gondii; Vaccines; Vertical Transmission; Viral; Virus; Work; Zika Virus; adverse pregnancy outcome; career; clinical practice; combat; congenital infection; design; diagnostic strategy; fetal; fetal loss; improved; intrauterine infection; meetings; microbial; multidisciplinary; neonate; pathogen; posters; programs; symposium; treatment strategy; vaccine strategy

ABSTRACT Support is requested for a Keystone Symposia conference entitled Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies, organized by Drs. Helen Lazear, Carolyn Coyne and David Aronoff. The conference will be held in Santa Fe, New Mexico from January 22-25, 2023. The placenta generally provides a robust barrier to the fetal compartment across which relatively few microbes are able to penetrate, and functions together with other defenses at the maternal-fetal interface to protect against congenital infections. Nonetheless, congenital pathogens including human cytomegalovirus, Zika virus, Toxoplasma gondii, and group B streptococcus can cause fetal loss, growth restriction, birth defects, and developmental delays. The list of congenital pathogens continues to grow; for example, the recently emergent virus SARS-CoV-2, can cause devastating adverse pregnancy outcomes independent of vertical transmission. In addition to pathogenic effects on the fetus and neonate, infections during pregnancy can have distinct impacts on maternal health, owing to the physiologic and immunologic effects of pregnancy. As such, there is a need to better understand the pathogenic mechanisms of congenital infections and immune defenses at the maternal-fetal interface, as well as to develop improved vaccine, treatment, and diagnostic strategies to combat congenital infections. But in many cases these infections can be difficult to study due to limitations in experimental systems and challenges in designing studies with human patients. This Keystone Symposia conference will bring together researchers investigating infections in pregnancy from a range of perspectives including basic biology, pathogenesis models, clinical studies, and patient care. The program is designed to highlight the new advances in understanding the pathogenic mechanisms of congenital infections. Other sessions will share recent developments in experimental systems for studying congenital infections, in addition to providing details on the latest developments in vaccines, therapeutics, and diagnostics. The program will also be designed to consider the effects of infections during pregnancy on maternal health, as well as on fetal, infant, and child health. This conference will provide an opportunity for researchers from diverse backgrounds to exchange ideas and develop new collaborations to promote future research on infections during pregnancy. Finally, this conference is being paired with another Keystone Symposia meeting on Maternal-Fetal Crosstalk. This will allow participants at both conference the chance to network and develop new collaborations through shared sessions and meals.

抽象的 请求支持题为“妊娠期感染：致病性”的 Keystone 研讨会 机制、实验进展和临床策略，由博士组织。海伦·拉泽尔，卡罗琳·科恩 和大卫·阿罗诺夫。会议将于2023年1月22日至25日在新墨西哥州圣达菲举行。 胎盘通常为胎儿室提供坚固的屏障，相对较少的微生物穿过该屏障 能够渗透，并与母胎界面的其他防御系统一起发挥作用，以保护 预防先天性感染。尽管如此，先天性病原体包括人类巨细胞病毒、寨卡病毒、 弓形虫和 B 族链球菌可导致胎儿流产、生长受限、出生缺陷和 发育迟缓。先天性病原体的名单继续增加；例如最近出现的 SARS-CoV-2 病毒可导致毁灭性的不良妊娠结局，与垂直传播无关。 除了对胎儿和新生儿的致病影响外，妊娠期间的感染还可产生明显的影响。 由于怀孕的生理和免疫作用，对孕产妇健康的影响。因此，有 需要更好地了解先天性感染和免疫防御的致病机制 母胎界面，以及开发改进的疫苗、治疗和诊断策略 对抗先天性感染。但在许多情况下，由于研究的局限性，这些感染可能很难研究 实验系统和设计人类患者研究的挑战。本次基石研讨会 会议将汇集研究人员从多个角度调查妊娠期感染 包括基础生物学、发病机制模型、临床研究和患者护理。该计划旨在 强调了解先天性感染致病机制的新进展。其他 此外，会议还将分享研究先天性感染的实验系统的最新进展 提供有关疫苗、治疗和诊断方面最新进展的详细信息。该计划将 还应考虑怀孕期间感染对孕产妇健康以及胎儿的影响， 婴儿和儿童健康。本次会议将为来自不同背景的研究人员提供机会 交流想法并开展新的合作，以促进未来关于妊娠期间感染的研究。 最后，本次会议与另一场关于母胎串扰的 Keystone 研讨会相结合。 这将使两次会议的参与者有机会通过以下方式建立联系并开展新的合作： 共享会议和膳食。