B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics

B 细胞和三级淋巴结构：癌症治疗的新兴靶点

基本信息

批准号：
10754008
负责人：
TERRY L. SHEPPARD
金额：
$ 0.6万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-18 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10754008
关键词：
Address Antibodies Antibody Response Autoantigens Autoimmune Diseases Autoimmunity B-Lymphocyte Subsets B-Lymphocytes British Columbia Cancer Burden Cancer Patient Career Choice Cell physiology Cells Cellular biology Clinical Collaborations Communities Data Discipline Disease Economic Burden Educational workshop Emotional Fostering Future Glean Goals Growth Immune response Immunology Immunotherapy Industry Knowledge Knowledge acquisition Learning Malignant Neoplasms Methodology Monoclonal Antibody Therapy Outcome Participant Patients Persons Process RNA vaccine Research Research Personnel Role Scientist Series Severities Shapes Societies Technology Therapeutic Vaccines Work cancer immunotherapy career clinical practice clinical translation combat effective therapy forging improved insight interest meetings member multidisciplinary novel pandemic disease patient response posters response symposium tertiary lymphoid organ therapy resistant training opportunity tumor tumor progression vaccine-induced antibodies virtual

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled B Cells and Tertiary Lymphoid Structures: Emerging Targets in Cancer Therapeutics, organized by Drs. Tullia Bruno, Brad Nelson, Daniel Hollern and Marie-Caroline Dieu-Nosjean. The conference will be held in Whistler, British Columbia from October 1-4, 2023. With vaccines, antibody-based immunotherapy, and scientific discoveries of B cell functional mechanisms, major breakthroughs are happening surrounding B cells. This marks a field of research that is poised for exponential growth in acquisition of knowledge and effective therapies. In particular, the novel insights into B cell biology have revealed conserved aspects across disease; for example, B cells are now recognized as critical players in Tertiary Lymphoid Structures (TLS) for both cancer patient response to immunotherapy and the severity of autoimmune disease. Likewise, B regulatory cells use mechanisms to protect from autoimmunity that are common to the mode by which they fuel cancer’s progression and resistance to therapy. By examining data across disciplines, scientists are gleaning major insights that shape the forward progression of the entire field of research. To foster the process of breakthroughs in the field of B cell research, we have established the B Cells in Cancer Consortium (BC3) to bring together this ever-growing community, and as expected, there is high interest. Specifically, our first year has built a constituency of more than 500 scientists for our virtual seminar series. This signifies a likelihood for an even larger audience given the expansive pace of immunology research driven by the global pandemic. With mRNA vaccines and monoclonal antibody therapies being a topic of high exposure, people are more informed than ever on B cell biology. This inaugural Keystone Symposia conference will be the first opportunity for this nascent field to meet together, providing a unique opportunity to forge new connections and catalyze future research into the importance of B cell function in cancer.

抽象的请求支持题为“B 细胞和三级淋巴结构”的 Keystone 研讨会：癌症治疗的新兴目标，由 Tullia Bruno、Brad Nelson、Daniel Hollern 博士和 Marie-Caroline Dieu-Nosjean。会议将于 2023 年 10 月 1 日至 4 日在不列颠哥伦比亚省惠斯勒举行。随着疫苗、基于抗体的免疫疗法以及 B 细胞功能机制的科学发现，主要 B 细胞周围正在发生突破，这标志着一个即将呈指数增长的研究领域。知识和有效疗法获取的增长，特别是对 B 细胞生物学的新见解。揭示了疾病中的保守方面；例如，B 细胞现在被认为是疾病中的关键参与者。三级淋巴结构 (TLS) 用于癌症患者对免疫治疗的反应和严重程度同样，B 调节细胞使用以下机制来预防自身免疫性疾病。通过检查数据，它们促进癌症进展和抵抗治疗的模式是共同的。跨学科的科学家们正在收集影响整个领域向前发展的重要见解为了促进 B 细胞研究领域的突破，我们建立了 B 细胞研究中心。癌症联盟（BC3）将这个不断增长的社区聚集在一起，正如预期的那样，有很高的具体来说，第一年我们的虚拟研讨会就吸引了 500 多名科学家。鉴于免疫学研究的快速发展，这意味着可能会有更多的受众。在全球大流行的推动下，mRNA 疫苗和单克隆抗体疗法成为热门话题。通过这次首届 Keystone 研讨会，人们比以往任何时候都更加了解 B 细胞生物学。这将是这个新兴领域第一次聚集在一起的机会，为打造新的领域提供了独特的机会连接并促进未来研究 B 细胞功能在癌症中的重要性。