Bioenergetics in Health and Diseases

健康与疾病中的生物能量学

基本信息

批准号：
10609120
负责人：
Thale Cross Jarvis
金额：
$ 1.74万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10609120
关键词：
Acceleration Adipose tissue Aging Area Bioenergetics Biology Clinical Collaborations Colorado Defect Development Disease Drug Targeting Educational workshop Elements Energy Metabolism Exercise Exercise Physiology Fatty acid glycerol esters Fibrosis Futile Cycling Future Health Heart Homeostasis Immunology Industry Knowledge Life Malignant Neoplasms Metabolic Metabolic Diseases Metabolism Methodology Mitochondria Molecular Neurodegenerative Disorders Outcome Pathology Process Proteomics Reporting Research Research Personnel Resolution Role Science Scientist Technology Underrepresented Populations Work age related career clinical practice design expectation human disease improved insight interdisciplinary collaboration lipidomics metabolomics mitochondrial metabolism multidisciplinary new technology next generation novel novel strategies posters programs symposium synergism tumor metabolism

Acceleration Adipose tissue Aging Area Bioenergetics Biology Clinical Collaborations Colorado Defect Development Disease Drug Targeting Educational workshop Elements Energy Metabolism Exercise Exercise Physiology Fatty acid glycerol esters Fibrosis Futile Cycling Future Health Heart Homeostasis Immunology Industry Knowledge Life Malignant Neoplasms Metabolic Metabolic Diseases Metabolism Methodology Mitochondria Molecular Neurodegenerative Disorders Outcome Pathology Process Proteomics Reporting Research Research Personnel Resolution Role Science Scientist Technology Underrepresented Populations Work age related career clinical practice design expectation human disease improved insight interdisciplinary collaboration lipidomics metabolomics mitochondrial metabolism multidisciplinary new technology next generation novel novel strategies posters programs symposium synergism tumor metabolism

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项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Bioenergetics in Health and Diseases, organized by Drs. Shingo Kajimura, Anna Krook and Jared Rutter. The conference will be held in Keystone, Colorado from January 15-19, 2023. Bioenergetic defects lie at the heart of metabolic disease, age-related disease, and cancer; however, what initiates the processes remain insufficiently understood. Over the last several years, the field has been transformed because of several breakthroughs and continues to expand. For instance, new mechanisms of futile cycling were identified. Novel regulators of mitochondrial metabolism and their roles in metabolic diseases and cancer have been reported. The sensitivity and resolution of metabolomics, lipidomics, and proteomics technologies are rapidly increasing. Thus, there is momentum to organize a conference that focuses on this exciting and emerging topic in the context of metabolic diseases, exercise, and cancer. The program includes a multi-disciplinary speaker lineup that will cover topics such as mitochondrial bioenergetics, cancer metabolism, exercise physiology, and metabolic diseases. Moreover, this conference will be held jointly with the Keystone Symposia conference, “Adipose Tissue: Energizing Good Fat.” This pairing will feature three shared sessions: Metabolic Flux in Health and Disease, Bioenergetics and Energy Homeostasis, and Adipose Tissue and Metabolic Diseases. It is anticipated that these topics will create numerous new collaborations and cross-disciplinary interactions. All in all, this conference was designed to discuss the emerging questions in the field of bioenergetics in the context of metabolic diseases at molecular and organismal levels, in addition to facilitating synergy between established and new investigators in the field of energy metabolism.

抽象的请求支持Keystone研讨会会议，题为“健康与疾病的生物能学”，由Drs组织。 Shingo Kajimura，Anna Krook和Jared Rutter。会议将在基斯通举行科罗拉多州，从2023年1月15日至19日。生物能缺陷是代谢疾病，与年龄有关的疾病和癌症的核心。但是，什么启动过程仍然不足。在过去的几年中，该领域一直是由于几个突破而发生了变化，并继续扩大。例如，新机制确定了徒劳的骑自行车。线粒体代谢的新型调节剂及其在代谢中的作用疾病和癌症已有报道。代谢组学，脂质组学和分辨率的敏感性和分辨率蛋白质组学技术正在迅速增加。那是组织会议的动力在代谢疾病，运动和癌症的背景下，重点介绍了这个令人兴奋的新兴话题。程序包括一个多学科的演讲者阵容，该阵容将涵盖线粒体生物能力等主题，癌症代谢，运动生理和代谢疾病。此外，这次会议将举行共同与Keystone研讨会会议“脂肪组织：充满活力的脂肪”。这个配对将特色三个会议：健康和疾病的代谢通量，生物能和能量稳态，以及脂肪组织和代谢疾病。预计这些主题将创造许多新的协作和跨学科互动。总而言之，这次会议旨在讨论在分子和有机层，除了促进该领域的既定研究者与新研究人员之间的协同作用能量代谢。