Engineering Multi-Cellular Living Systems

工程多细胞生命系统

• 批准号: 10462913
• 负责人: Thale Cross Jarvis
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462913
• 关键词: Address; Area; Behavior; Biochemical; Biological; Biological Process; Cell Communication; Cells; Collaborations; Colorado; Communities; Complex; Development; Developmental Biology; Discipline; Disease; Educational workshop; Engineering; Environment; Ethics; Future; Goals; Health; Human; Industry; Knowledge; Learning; Medicine; Mentors; Methodology; Methods; Modeling; Montserrat; Natural regeneration; Organism; Organoids; Outcome; Process; Research; Research Personnel; Robot; Scientist; Subcellular structure; System; Technology; Translations; Work; career; clinical practice; design; interest; mechanical signal; multidisciplinary; novel strategies; organ on a chip; posters; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Engineering Multi-Cellular Living Systems organized by Drs. Roger D. Kamm, Nuria Montserrat Pulido, Jianping Fu. The conference will be held in Keystone, Colorado from April 3-6, 2022. Developing the capability to design, engineer and produce complex, multi-cellular engineered living systems (M-CELS) to emulate natural processes (development, regeneration, and disease) or to create new functionality is a grand challenge facing the scientific community. The manufacturing and design of these complex multicellular machines and systems (e.g., organ-on-chip models, biological robots, and organoids) require fundamental understanding of interactions between cells and their environment, their control by biochemical and mechanical cues, and coordinated behavior of functional cell clusters through computational and experimental methods. Cell interactions, controls across scales (from subcellular structures to multi- cellular systems) and behaviors will be central themes of the conference. The primary aim of this conference is to bring together a multidisciplinary group of forward-looking researchers seeking to explore these complex biological interactions and the emergent behaviors they produce, with the goal of creating responsibly engineered multi-cellular systems with specific functions.

抽象的 请求支持题为“工程多细胞生命系统”的 Keystone 研讨会 由博士组织。罗杰·D·卡姆、努里亚·蒙特塞拉特·普利多、付建平。会议将于 2022 年 4 月 3 日至 6 日在科罗拉多州基斯通举行。 发展设计、工程和生产复杂的多细胞工程生命系统的能力 （M-CELS）模拟自然过程（发育、再生和疾病）或创造新的 功能性是科学界面临的巨大挑战。这些产品的制造和设计 复杂的多细胞机器和系统（例如芯片器官模型、生物机器人和类器官） 需要对细胞与其环境之间的相互作用以及它们的控制有基本的了解 生化和机械线索，以及通过计算功能细胞簇的协调行为 和实验方法。细胞相互作用，跨尺度控制（从亚细胞结构到多细胞结构） 蜂窝系统）和行为将是会议的中心主题。本次会议的主要目的 是汇集一个由具有前瞻性的研究人员组成的多学科小组，寻求探索这些复杂的 生物相互作用及其产生的突发行为，目标是负责任地创造 设计具有特定功能的多细胞系统。