2023 Liquid Crystals Gordon Research Conference & Gordon Research Seminar

2023年液晶戈登研究会议

• 批准号: 10683604
• 负责人: Cecilia Leal
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683604
• 关键词: 2019-nCoV; Academia; Address; Alzheimer' s Disease; Applied Research; Area; Basic Science; Biological; Biology; Biosensing Techniques; Biosensor; Birth; Capsid; Caring; Cell membrane; Chemistry; Collaborations; Colloids; Color; Communities; Complement 2; Detection; Diagnosis; Disease; Elastomers; Engineering; Environment; Equity; Faculty; Female; Fostering; Future; Goals; Hour; Human body; Implant; Industry; International; Joints; Leadership; Life; Lipids; Liquid substance; Medical; Membrane Lipids; Membrane Microdomains; Mentors; Military Personnel; Minority Groups; Minority Participation; Mission; Muscle; National Institute of Biomedical Imaging and Bioengineering; Nature; New Hampshire; Nucleic Acids; Oral; Participant; Pharmacologic Substance; Phase; Phase Transition; Physics; Play; Polymers; Postdoctoral Fellow; Prevention; Proteins; Reporting; Research; Research Personnel; Robotics; Role; Science; Scientist; Students; Suspensions; Technology; Toxin; Underrepresented Minority; United States National Institutes of Health; Universities; Viral; Virus; Voice; Water; Woman; active lifestyle; career; elastomeric; empowerment; experimental study; flexibility; liquid crystal; materials science; meetings; pathogen; peer; posters; prevent; self assembly; sensor; social; symposium; theories; tool

Project Summary Significance, timeliness and rationale. NIBIB's mission is to transform through engineering the understanding of disease and its prevention, detection, diagnosis, and treatment. Life would not be possible without liquid crystalline (LC) order. The most celebrated example is the unique combination of flexibility and confining ability of cell membranes which is possible because lipids cooperatively aggregate into a lamellar LC phase in water. The phase separation underlying the lipid raft paradigm of plasma membrane organization bears all the hall- marks of inter-LC phase transitions, as does separation in suspensions of amyloidogenic protein fibrils in Alz- heimer's disease. Many viruses, e.g., SARS-CoV-2, are enveloped in a lipid membrane and they may employ LC order for packing their nucleic acid cargo. Non-biological LCs have turned out to be sensitive in detecting and reporting on the presence of pathogens and toxins, making them highly interesting for autonomous bio- /chemosensors. LC formation is thus an integral component of what keeps us healthy and causes disease, and they are emerging as a powerful tool for detecting disease agents. Although this connection is known since long, it has until now been researched only marginally, constituting an under-explored opportunity in addressing soci- etal needs. Today, the international LC research community is undergoing a rebirth, fully embracing these as- pects. Interdisciplinary crossovers where LC science meets biological, life and pharmaceutical sciences, and engineering and materials science, play a groundbreaking role in leveraging the opportunities. Additional impact on the core fields of the NIH-NIBIB mission comes from, e.g., the exploration of LC elastomers in soft actuators or implants in the human body. Objective. The chairs seek support for the Gordon Research Conference (GRC) and Seminar (GRS) on Liquid Crystals 2023:“ From Nature to Transformational Technology through Liquid Crys- tal Science”, Southern New Hampshire University, Manchester, NH, June 24–25 (GRS), June 25-June 30 (GRC), 2023. The joint meetings will bring together US and international researchers at the forefront of today's vibrant LC science, spanning its full breadth and connecting academia, industry and military labs, young and senior, and harnessing every opportunity to promote women and underrepresented minorities as speakers, discussing lead- ers and participants. Approach. 30 prominent speakers have confirmed our invitations to present unpublished cutting-edge research, covering, e.g., LCs in and from nature, LC-self-assembly in colloids and polymers, and in emerging applications. 52% of speakers are female and 37% are non-white. Academic speakers are comple- mented by 2 industry and 2 military research lab speakers. Additionally, 5 speaker slots will be given to excellent young scientists selected from submitted poster abstracts. To further strengthen the voice of young researchers, the GRC is preceded by the GRS, catering only to students and post-docs and providing mentoring and career advice, and during the GRC, young scientists will be given precedence in all scientific discussions.

项目摘要 意义，及时性和理由。尼比卜的使命是通过工程理解来改变 疾病及其预防，检测，诊断和治疗。没有液体，生活将是不可能的 结晶（LC）顺序。最著名的例子是灵活性和限制能力的独特组合 细胞膜的可能性是可能的，因为脂质在水中合作地聚集成层状LC相。 质膜组织的脂质筏范式的基础的相位分离带有所有厅 LC间过渡的痕迹，在ALZ-淀粉样蛋白原纤维悬浮液中的分离也是如此 海默氏病。许多病毒，例如SARS-COV-2，都包裹在脂质膜上，它们可能会采用 LC命令包装其核酸货物。事实证明，非生物LC在检测和 报道存在病原体和毒素的存在，使其对自主生物的有趣 /化学传感器。因此，LC的形成是使我们保持健康并引起疾病的组成部分 它们正在成为检测疾病药物的强大工具。虽然这种连接从长期以来就已经知道 到目前为止，它的研究仅是一小段研究，构成了解决社会问题的探索机会。 eT的需求。如今，国际LC研究界正在重生，完全拥抱这些 螺旋。 LC科学符合生物学，生活和药物科学的跨学科跨界跨界以及 工程和材料科学，在利用机会方面发挥着突破性的作用。其他影响 在NIH-NIBIB任务的核心领域，例如，在软执行器中探索LC弹性体的探索 或人体中的刺激性。客观的。椅子寻求支持戈登研究会议（GRC） 和液晶2023上的研讨会（GRS）：“从自然到转化技术到液体crys- 6月25日至25日，新罕布什尔州南部新罕布什尔大学，新罕布什尔大学南部北部科学” 2023年。联合会议将使我们和国际研究人员聚集在今天充满活力的最前沿 LC科学，涵盖其完整的广度和连接学术界，工业和军事实验室，年轻和高级，以及 利用所有机会来促进妇女和代表人数不足的演讲者，讨论主角 - ERS和参与者。方法。 30位杰出的演讲者已经确认了我们的邀请，以表达未出版 尖端的研究，例如自然界和来自自然的LCS，lc-sef-semplble，以及聚合物中的LC-sef-emembly，以及 在新兴应用程序中。 52％的说话者是女性，37％是非白人。学术发言人是完整的 - 由2个行业和2位军事研究实验室发言人进行。此外，将提供5个扬声器插槽 从提交的海报摘要中选出的年轻科学家。为了进一步加强年轻研究人员的声音， GRC之前是GRS，仅适合学生和毕业后，并提供心理和职业 建议，在GRC期间，在所有科学讨论中都将获得年轻科学家的优势。