Facility Management, Maintenance and Operation Core

设施管理、维护和运营核心

• 批准号: 10793908
• 负责人: Raymond Paul Goodrich
• 金额: $ 133.84万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793908
• 关键词: 2019-nCoV; Academia; Address; Administrative Supplement; Advocate; Aging; Animal Husbandry; Award; Basic Science; Biological; Biological Sciences; Burkholderia pseudomallei; Calibration; Capital; Career Choice; Categories; Certification; Client; Collaborations; Colorado; Communicable Diseases; Communication; Conflict (Psychology); Cyclic GMP; Data; Dedications; Discipline; Disease; Eastern Equine Encephalitis Virus; Economic Burden; Education; Emerging Communicable Diseases; Ensure; Entrepreneurship; Environment; Equipment; Evaluation; Fees; Foundations; Francisella tularensis; Funding; Genus Mycobacterium; Goals; Good Manufacturing Process; Government Agencies; Grant; Hazardous Chemicals; Hazardous Substances; Human Resources; Industry; Infectious Diseases Research; Information Systems; Information Technology; Infrastructure; Institution; Investments; Laboratories; Leadership; Leprosy; Maintenance; Melioidosis; Middle East Respiratory Syndrome Coronavirus; Mission; Modernization; Monkeypox; National Institute of Allergy and Infectious Disease; Operations Research; Parents; Pharmacologic Substance; Plague; Process; Public Health; Research; Research Personnel; Research Support; Resolution; Resource Allocation; Resource Development; Resources; Risk; Science; Services; Site; Structure; System; Training; Translational Research; Tuberculosis; Tularemia; Universities; Update; Venezuelan Equine Encephalomyelitis; Vertebral column; Veterinary Medicine; Vision; Work; Workforce Development; aged; biodefense; biosafety level 3 facility; biosecurity; college; cost; design; emerging pathogen; faculty research; health economics; improved; instrument; laboratory facility; manufacture; non-tuberculosis mycobacteria; operation; pandemic disease; pandemic potential; pathogen; pathogenic bacteria; professional atmosphere; programs; repaired; response; socioeconomics; usability; viral pandemic; visiting scholar

Project Summary: The BSL3 suites in the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University (CSU) have been operational and at capacity since being commissioned. These facilities support research in response to new threats from established pathogens, such as Mycobacterium spp. (tuberculosis, leprosy, and emerging diseases caused by non-tuberculosis mycobacteria) and high consequence, select agent pathogens, such as Eastern Equine Encephalitis Virus, Venezuelan Equine Encephalitis, Francisella tularensis, and Burkholderia pseudomallei. The RMRBL BSL3 is required to pivot and rapidly respond to new, emerging pathogens with pandemic potential. The RMRBL has been exemplary, researching new threats such as MERS-CoV, MPox, and SARS-CoV-2. The RMRBL BSL3 thus represents the backbone of research capabilities in infectious disease at CSU. CSU, in turn has supported the facility for the past 15 years. CSU’s support includes much of the day-to-day operating costs of the RMRBL BSL3 facilities; remaining costs are covered by assessing user fees to CSU researchers based on square footage and entries. Expenses beyond day-to-day operational costs, including non-annual facilities repairs and replacement upgrades require additional advocating and are addressed when eminently needed. This disrupts crucial operations. Work within the BSL3 comes with a sacrifice to personal comfort due to the requirements for biosafety and biosecurity, along with the inherent risk of work on high consequence pathogens. Maintaining safe, operational and appropriate scientific instruments is challenged as servicing these instruments is difficult and frequently results in the need to replace equipment. The consequence of the cost, work environment, deprecating equipment and operational disruptions is our inability to maintain a trained workforce and sufficiently technically equipped BSL3 ‘warm ready’ space. In response to this challenge, we propose our Core 1 – Facility Management, Maintenance & Operations. This core is strategically designed to resolve many of the RMRBL BSL3 challenges through three functional aims; Aim 1 - Management, will improve upon the current structure for communication across research and support teams; Aim 2 – Maintenance, will maintain the RMRBL BSL3 facilities functionality through proactive preventative maintenance, reducing unplanned disruptions; and finally, Aim 3 – Operations, will institute dedicated operational and animal husbandry support and improve IT-communications within the RMRBL BSL3/ABSL3. Our comprehensive approach to improving the management, maintenance, and operations of the RMRBL BSL3 will result in an improved RMRBL BSL3 system that exemplifies communication and collaboration across our diverse leadership and research teams in a biosafe and bio-secure compliant environment. As a result, the penultimate goal of this core - to perpetuate warm ready RMRBL BSL3 facilities; compliant with the dynamic requirements for biosafety and biosecurity, appropriately resourced, and responsive to our national and state RBL mission – will be achieved.

项目摘要：落基山区域生物植物实验室（RMRBL）的BSL3套件位于 科罗拉多州立大学（CSU）自委托以来一直处于运营状态，并且有能力。这些 设施支持研究，以应对已建立病原体的新威胁，例如分枝杆菌 spp。 （结核病，麻风病和由非结核分枝杆菌引起的新兴疾病）和较高 结果，选择的药物病原体，例如东马脑炎病毒，委内瑞拉马 脑炎，francisella tularensis和burkholderia pseudomallei。 RMRBL BSL3需要旋转和 迅速对具有大流行潜力的新的新兴病原体做出了反应。 rmrbl是典范， 研究MERS-COV，MPOX和SARS-COV-2等新威胁。 RMRBL BSL3因此代表 CSU传染病研究能力的骨干。 CSU又支持了 过去15年。 CSU的支持包括RMRBL BSL3设施的大部分日常运营成本； 根据平方英尺和条目评估CSU研究人员的用户费用，剩余成本涵盖了剩余成本。 日常运营成本以外的费用，包括非年轻设施维修和更换 升级需要额外的倡导，并在需要时解决。这破坏了至关重要的 运营。由于要求 生物安全和生物安全，以及在高后果病原体上进行工作的继承风险。维护 安全，操作和适当的科学仪器受到挑战，因为为这些乐器提供服务是困难的 并且经常导致需要更换设备。成本，工作环境的结果， 贬值设备和操作中断是我们无法维持训练有素的劳动力和 适当地在技术上等效的BSL3“温暖的现成”空间。为了应对这一挑战，我们提出了核心 1 - 设施管理，维护和操作。该核心在战略上设计旨在解决许多 RMRBL BSL3通过三个功能目标挑战；目标1-管理，将改善当前 跨研究和支持团队进行交流的结构；目标2 - 维护，将维护 RMRBL BSL3设施通过主动预防性维护功能，减少计划外 干扰；最后，AIM 3 - 操作将建立专门的运营和畜牧业支持 并改善RMRBL BSL3/absl3中的IT通信。我们改进的全面方法 RMRBL BSL3的管理，维护和操作将改善RMRBL BSL3 在我们的潜水者领导和研究团队中的沟通和协作的系统 生物安全和生物安全的环境。结果，这个核心的倒数第二个目标 - 永久化 温暖准备的RMRBL BSL3设施；符合生物安全和生物安全的动态要求， 将实现适当的采购，并对我们的国家和州RBL任务做出响应。