Digital monitoring of autonomic activity to detect empathy loss in behavioral variant frontotemporal dementia

对自主活动进行数字监测以检测行为变异型额颞叶痴呆的同理心丧失

基本信息

批准号：
10722938
负责人：
Emma Rhodes
金额：
$ 16.29万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10722938
关键词：
Accelerometer Address Adult Age Anterior Area Arousal Atrophic Autonomic nervous system Behavior Behavioral Behavioral Symptoms Caregiver Burden Caregivers Classification Clinical Cognitive Collaborations Cues Data Dementia Detection Development Devices Digital biomarker Distress Early Diagnosis Electrocardiogram Emotional Emotions Empathy Environment Family Functional Magnetic Resonance Imaging Functional disorder Galvanic Skin Response Goals Impaired cognition Individual Insula of Reil Investigation K-Series Research Career Programs Knowledge Link Machine Learning Measurement Measures Mediating Mediation Mentorship Methodology Methods Modeling Monitor Morphologic artifacts Motion Movement Nervous System Physiology Neuroanatomy Neurodegenerative Disorders Neuropsychology Output Parasympathetic Nervous System Participant Pathway Analysis Patients Pattern Pennsylvania Performance Persons Phase Physiological Reporting Research Research Personnel Rest Role Sampling Scientific Inquiry Signal Transduction Sinus Standardization Statistical Methods Stimulus Sympathetic Nervous System Symptoms Technology Testing Training Universities behavior measurement behavioral variant frontotemporal dementia cingulate cortex clinical diagnosis cognitive function daily functioning design detector diagnostic accuracy digital digital monitoring early onset feature selection frontotemporal degeneration improved innovation machine learning method multimodal neuroimaging network dysfunction neuroimaging neuropsychiatric symptom novel recruit respiratory response segregation sensor skills smart watch social social deficits symptom treatment wearable device

项目摘要

PROJECT SUMMARY/ABSTRACT Patients with behavioral variant frontotemporal dementia (bvFTD) develop progressive and highly distressing symptoms of social and emotional dysfunction, including loss of empathy for other people. Scientific research has struggled to understand the specific causes of empathy loss in bvFTD because empathy is difficult to measure in a way that is meaningful and not biased by other factors, such as caregiver burden, and because individuals with bvFTD have highly variable patterns of cognitive and behavioral functioning. A relatively unexplored but promising avenue of scientific inquiry is the role of autonomic nervous system (ANS) activity in empathy loss in bvFTD. The ANS is comprised of two complementary subsystems, the sympathetic and parasympathetic nervous systems, which operate together to increase and decrease levels of physiologic arousal in response to cues from the environment. Patients with bvFTD show subtle abnormalities in ANS activity that are linked to symptoms of social dysfunction, including loss of empathy, but this line of research has been hindered by reliance on traditional methods of measuring ANS output, namely hard-wired EKG and skin conductance sensors, which restrict the movement of the patient and are sensitive to motion artifacts. Recent advances in wearable smartwatch technology allow for precise, unobtrusive measurement of ANS activity with built-in motion detectors to account for changes in ANS signals that are due to movement. Smartwatch technology is well-suited for continuous measurement of ANS functioning to detect subtle abnormalities that correspond to behavioral measures of empathy in bvFTD. This project has the potential to identify specific physiologic contributions to empathy loss in bvFTD, which can be used to develop new treatments and improve early detection of social and emotional dysfunction in bvFTD.

项目摘要/摘要行为变异额颞痴呆（BVFTD）的患者发展为渐进且高度痛苦的患者社会和情感功能障碍的症状，包括失去对他人的同理心。科学研究一直在努力理解BVFTD同理心损失的具体原因，因为很难以有意义的方式衡量，不受其他因素的偏见，例如护理人员负担，因为具有BVFTD的个体具有高度可变的认知和行为功能模式。一个相对尚未开发但有前途的科学探究途径是自主神经系统（ANS）活动的作用 BVFTD的同理心损失。 ANS由两个互补子系统组成副交感神经系统，该系统共同起作用以增加和降低生理水平响应环境线索的唤醒。 BVFTD患者在ANS中显示出微妙的异常与社会功能障碍的症状有关的活动，包括失去移情，但是这一研究线依靠传统的测量ANS输出方法，即硬连线的EKG和皮肤电导传感器，限制了患者的运动，并且对运动伪影敏感。可穿戴智能手表技术的最新进展允许对ANS进行精确，不引人注目的测量带有内置运动探测器的活动，以说明由于移动引起的ANS信号的变化。智能手表技术非常适合连续测量ANS功能以检测微妙的与BVFTD中移情行为度量相对应的异常。这个项目有可能确定对BVFTD中移情损失的特定生理贡献，可用于开发新在BVFTD中，治疗并改善了对社会和情感功能障碍的早期发现。