Sleep Extension: A Novel Intervention for Weight Loss in Young Adults

延长睡眠：年轻人减肥的新干预措施

• 批准号: 10753226
• 负责人: Esra Tasali
• 金额: $ 73.7万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10753226
• 关键词: Accelerometer; Address; Affect; Age; Behavior; Behavioral; Biological; Biological Factors; Biological Markers; Blood Pressure; Body Weight Changes; Body Weight decreased; Body fat; Body mass index; Caloric Restriction; Cardiometabolic Disease; Clinic; Cognitive; Continuous Glucose Monitor; Counseling; Custom; Data; Data Display; Diet; Dietary intake; Drowsiness; Dual-Energy X-Ray Absorptiometry; Eating; Electrocardiogram; Energy Intake; Energy Metabolism; Epidemiology; Feedback; Food; Glucose; Health; Heart Rate; Home; Hour; Hunger; Hyperphagia; Indirect Calorimetry; Intervention; Intervention Trial; Knowledge; Laboratories; Laboratory Study; Leptin; Life; Life Style; Lipids; Maintenance; Measures; Methods; Monitor; Motivation; Obesity; Observational Study; Outcome; Overweight; Participant; Phase; Physical activity; Physical assessment; Population Study; Prevalence; Psychosocial Factor; Public Health; Randomized; Regulation; Research; Rest; Roentgen Rays; Self Efficacy; Sleep; Sleep Deprivation; Technology; Time; Weight; Work; alertness; behavior change; cardiometabolic risk; cardiometabolism; clinical application; dietary; dietary restriction; doubly-labeled water; emotional eating; energy balance; evidence base; executive function; fitbit; ghrelin; improved; indexing; insight; laboratory experiment; lifestyle intervention; novel; novel strategies; obesity development; obesity prevention; obesity risk; prevent; primary outcome; psychosocial; randomized, clinical trials; response; secondary outcome; sedentary; sleep behavior; sleep pattern; smartphone application; success; telecoaching; total energy expenditure; weight loss intervention; weight loss program; wireless; young adult

PROJECT SUMMARY Despite widespread efforts to implement lifestyle interventions aimed at restricting energy intake and increasing physical activity, weight loss success has been limited and obesity prevalence continues to rise. Thus, there is a critical need to develop novel strategies to prevent obesity and related cardiometabolic risks. Short sleep duration is a highly prevalent behavior and is strongly associated with obesity risk among young adults. Experimental laboratory evidence indicates that short sleep duration may increase obesity risk primarily through food-seeking behavior and overeating. We have recently demonstrated that short-term sleep extension in real- life settings in young adults with habitual short sleep reduces energy intake by a significant amount, and thus might be a potent strategy to improve weight loss outcomes in lifestyle interventions with calorie-restricting diets. To our knowledge, no prior weight loss intervention trial specifically examined the effects of extending sleep duration on weight loss outcomes in young adults. We, thus, propose a randomized clinical trial to determine whether weight loss outcomes in lifestyle interventions can be improved by adding an intervention component to extend sleep duration in overweight young adults with habitual short sleep duration. Overweight young adults who habitually sleep <6.5 hours will be randomized to either a lifestyle intervention alone (diet and activity counseling) or a lifestyle plus sleep intervention (diet, activity, and sleep counseling). All participants will receive a technology-supported intensive lifestyle intervention for weight loss with biweekly remote coaching for 6 months (Intervention). Participants assigned to lifestyle plus sleep intervention will also receive individualized sleep counseling to extend sleep duration, proven successful in our prior work, and tailored feedback. Participants will continue their assigned intervention for an additional 6 months without frequent contact (Maintenance). Sleep will be objectively assessed by accelerometry. Participants will self-monitor their diet (record all dietary intake into a custom smartphone app), physical activity (by accelerometry), and self-weigh daily on a wireless scale. Our specific aims are to determine whether lifestyle plus sleep intervention produces a greater weight loss (Aim1) and a greater reduction in objectively assessed (using doubly labeled water/energy balance method) energy intake (Aim2), as compared with lifestyle intervention alone. We will compare the change in weight (primary outcome) and energy intake (secondary outcome) at 6 months between groups. We will collect additional data on behavioral, biological, and psychosocial factors to explore their effects on intervention responses and generate novel insights. Weight change at 12 months (end maintenance) will be an exploratory outcome. If effective, data from this trial would strongly support incorporating sleep interventions into behavioral weight loss programs and provide the evidence base needed to guide tailored behavior change strategies for preventing obesity and related cardiometabolic risk in young adults with insufficient sleep duration.

项目概要 尽管人们广泛努力实施旨在限制能量摄入和增加能量摄入的生活方式干预措施 体力活动、减肥成功率有限，肥胖患病率持续上升。因此，有 迫切需要制定新的策略来预防肥胖和相关的心脏代谢风险。睡眠时间短 持续时间是一种非常普遍的行为，并且与年轻人的肥胖风险密切相关。 实验实验室证据表明，睡眠时间短可能会增加肥胖风险，主要是通过 寻求食物的行为和暴饮暴食。我们最近证明，短期睡眠延长实际上 习惯性短睡眠的年轻人的生活环境会显着减少能量摄入，因此 可能是通过限制热量饮食的生活方式干预来改善减肥效果的有效策略。 据我们所知，之前没有减肥干预试验专门检查延长睡眠的影响 年轻人减肥结果的持续时间。因此，我们提出一项随机临床试验来确定 是否可以通过在生活方式干预中添加干预成分来改善减肥效果 延长习惯性短睡眠时间的超重年轻人的睡眠时间。超重的年轻人 习惯性睡眠<6.5小时的人将被随机分配到单独的生活方式干预组（饮食和活动） 咨询）或生活方式加睡眠干预（饮食、活动和睡眠咨询）。所有参与者将 接受技术支持的强化生活方式干预以减轻体重，并每两周进行一次远程辅导 6个月（干预）。被分配生活方式加睡眠干预的参与者也将接受个性化的治疗 睡眠咨询可延长睡眠时间，在我们之前的工作中证明是成功的，并且提供量身定制的反馈。 参与者将继续指定的干预措施 6 个月，无需频繁联系 （维护）。睡眠将通过加速度测量进行客观评估。参与者将自我监控自己的饮食 （将所有饮食摄入量记录到定制智能手机应用程序中）、身体活动（通过加速度测量）和自我称重 每天以无线规模进行。我们的具体目标是确定生活方式加上睡眠干预是否会产生 更大的体重减轻（目标1）和客观评估的更大减少（使用双重标记的水/能量） 平衡法）能量摄入（目标2），与单独生活方式干预相比。我们将比较 6 个月时组间体重（主要结果）和能量摄入（次要结果）的变化。我们 将收集有关行为、生物和心理社会因素的额外数据，以探讨它们对 干预反应并产生新颖的见解。 12 个月（维持结束）时的体重变化将是 探索性的结果。如果有效，该试验的数据将强烈支持将睡眠干预纳入 行为减肥计划并提供指导定制行为改变所需的证据基础 预防睡眠时间不足的年轻人肥胖和相关心脏代谢风险的策略。