Progress in Vaccine Development for Infectious Diseases

传染病疫苗研发进展

• 批准号: 10467880
• 负责人: Thale Cross Jarvis
• 金额: $ 0.55万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-27 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467880
• 关键词: Academia; Address; Adjuvant; Advocate; Age; Animal Model; Antigens; Area; Biological Markers; Biology; Biomedical Engineering; Collaborations; Colorado; Communicable Diseases; Communities; Coupled; DNA; Development; Educational workshop; Empirical Research; Fostering; Future; Immune response; Immunization; Immunologist; Immunology; Industry; Knowledge; Learning; Life; Mentors; Messenger RNA; Methodology; Modern Medicine; Outcome; Participant; Proteins; Research; Research Personnel; Savings; Scheme; Science; Scientist; Speed; Structural Biologist; Structure; System; Technology; Vaccine Production; Vaccines; Viral Vector; Work; base; career; clinical implementation; clinical practice; combat; design; human pathogen; immunogenicity; nanomaterials; nanoparticle; novel; pandemic preparedness; pathogen; posters; programs; screening; structural biology; symposium; vaccine development; vaccine distribution; vaccine platform; vaccine response; vaccinology

ABSTRACT Support is requested for a Keystone Symposia conference entitled Progress in Vaccine Development for Infectious Diseases, organized by Drs. Katalin Kariko, Karin Loré and Norbert Pardi. The conference will be held in Breckenridge, Colorado from June 1-4, 2022. Vaccines are the cornerstones of modern medicine, saving millions of lives every year. Due to the fast progress in better understanding the biology of certain pathogens coupled with recent technological advances in the fields of immunology, structural biology and nanomaterial development, science has entered a new golden age of vaccinology. This conference will focus on presenting state-of-the-art vaccine technologies (mRNA, viral vectors, protein nanoparticles, adjuvants), recent advancements in understanding (and potentially manipulating) vaccine-induced immune responses and key aspects of structure-based antigen design that allows us to develop better vaccine immunogens. Combining these overlapping and strongly synergistic aspects of vaccine development will foster collaborations between conference participants that may result in novel, very effective vaccines in the future. Moreover, most of the currently used vaccines have been developed by empirical research without the involvement of immunologists, structural biologists or biomedical engineers. However, it has become evident in recent years that the empirical approach is not sufficient for successful vaccine development against hard-to-target pathogens. To successfully combat these pathogens, the community needs to better understand how to induce protective immune responses against them and need to develop better adjuvants, vaccine platforms or immunization schemes. This "combined" approach requires a tight cooperation between interdisciplinary groups of scientists who will all be in attendance at this Keystone Symposia conference. Finally, the program includes a session focused on vaccine diplomacy, to address key challenges regarding vaccine production and distribution and advocate for a more equitable system for worldwide vaccine distribution.

抽象的 请求支持题为“疫苗开发进展”的 Keystone 研讨会 传染病，由 Katalin Kariko、Karin Loré 和 Norbert Pardi 博士组织。 2022 年 6 月 1 日至 4 日在科罗拉多州布雷肯里奇举行。 疫苗是现代医学的基石，每年挽救数百万人的生命。 更好地了解某些病原体的生物学进展以及最新的技术进步 在免疫学、结构生物学和纳米材料开发领域，科学进入了一个新的阶段 本次会议将重点介绍最先进的疫苗技术。 （mRNA、病毒载体、蛋白质纳米粒子、佐剂）、理解方面的最新进展（以及潜在的 操纵）疫苗诱导的免疫反应以及基于结构的抗原设计的关键方面 使我们能够结合这些重叠和强协同作用来开发更好的疫苗免疫原。 疫苗开发的各个方面将促进会议之间的合作，这可能会导致 未来将出现新型、非常有效的疫苗，而且目前使用的大多数疫苗都是。 由实证研究开发，没有免疫学家、结构生物学家或生物医学家的参与 然而，近年来，很明显，经验方法对于工程师来说是不够的。 成功开发针对难以靶向的病原体的疫苗 为了成功对抗这些病原体， 社区需要更好地了解如何诱导针对他们的保护性免疫反应，并且需要 开发更好的佐剂、疫苗平台或免疫方案需要这种“组合”方法。 跨学科科学家小组之间的紧密合作，他们都将出席本次 Keystone 最后，该计划包括一场专注于疫苗外交的会议，以解决关键问题。 疫苗生产和分配方面的挑战，并倡导建立更公平的制度 全球疫苗分发。