CORE--IRRADIATION

核心--辐照

• 批准号: 7310506
• 负责人: Robert C Young
• 金额: $ 2.75万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7310506
• 关键词: biomedical facility; ionizing radiation; neoplasm /cancer; whole body irradiation dosage; biomedical facility; ionizing radiation; neoplasm /cancer; whole body irradiation dosage

The Irradiation Facility at Fox Chase Cancer Center (FCCC) manages the shared use of ionizing radiation sources according to procedures mandated in our license from the Nuclear Regulatory Commission (NRC). Management and maintenance of these potentially dangerous, costly devices ($100,000-$200,000 each) as a shared resource for multiple users facilitates administration, quality assurance, safety and regulatory compliance. The Facility consists of two different irradiators, each sited optimally for its specific use. They produce fields of Cesium-137 gamma-rays to irradiate molecules in solution, cell cultures, rodent tumors or normal tissues for studies of radiobiologic mechanisms, to suppress immune response, to induce DMA damage and/or mitotic arrest, and to sterilize cell and drug preparations. The Shepherd Model 280 irradiator is situated in the Laboratory Animal Facility and used mainly for whole body irradiation of animals used in immunobiology research (see Hayakawa et al., J. Exp. Med. 197:87-99, 2003; Allman et al., J. Immunol. 167:6834-6840, 2001). The panoramic Shepherd Model 81-14R irradiator is situated in the basement of the Reimann Building. It was used 223 times in 2003 primarily for the irradiation of cells (see, for example, Katz et al., J. Virol. 76:5422-5434, 2002; Mu et al., Int. J. Radiat. Oncol. Biol. Phys. 58:336-343, 2004). Oversight of Facility operation is provided by the Facility Manager, Facility Director, Radiation Safety Officer, Radiation Safety Committee, FCCC Administration and the NRC. Facility staff operate various radiation dosimeters to accurately determine the dose to experimental set-ups and is available to FCCC investigators for planning radiation experiments, to assist infrequent users, for training individuals to become qualified irradiator users in accord with NRC and other safety regulations and for overseeing the annual maintenance and quality assurance of equipment. Inventories of the radioactive sources are made at intervals determined by the Homeland Security threat level. Over the last Core grant cycle, the Facility was used by 24 peer-reviewed funded investigators from ten FCCC research Programs in two Center Divisions. Currently, 92% of Facility use is by peer-reviewed funded investigators. Facility use has increased about 10% per year and is projected to increase 5-10% per year during the next Core grant cycle.

Fox Chase Cancer Center（FCCC）的辐照设施管理着共同使用 根据核许可证中规定的程序电离辐射源 监管委员会（NRC）。这些潜在危险的管理和维护， 昂贵的设备（每台$ 100,000- $ 200,000）作为多个用户的共享资源 管理，质量保证，安全性和法规合规性。该设施由两个 不同的辐照器，每个辐照器都最适合其特定用途。它们产生剖腹产137 伽马射线以照射溶液，细胞培养物，啮齿动物肿瘤或正常组织中的分子 放射生物学机制的研究，以抑制免疫反应，诱导DMA损伤和/或有丝分裂停滞，并对细胞和药物制剂进行消毒。 Shepherd Model 280辐射器位于实验室动物设施中，主要用于用于免疫生物学研究中使用的动物的全身照射（参见Hayakawa等，J。Exp。Med。197：87-99，2003; Allman等，J.Immunol。167：6834-6840，2001）。 Panoramic Shepherd 81-14R辐照器位于Reimann大楼的地下室。它在2003年主要用于细胞的辐射223次（例如，参见Katz等人，J。Virol。76：5422-5434，2002; Mu等，Mu等，Int。J.Radiat。Oncol。Biol。Biol。Biol。Phys。58：336-343，2004）。设施经理的监督由设施经理，设施主管，辐射安全官员，辐射安全委员会，FCCC管理局和NRC提供。设施工作人员操作各种辐射剂量计，以准确确定实验设置的剂量，并可为FCCC研究人员提供计划辐射实验，以协助用户提供频繁的用户，以培训个人根据NRC和其他安全法规成为合格的辐射用户，并监督设备的年度维护和质量保证。放射性来源的库存是由国土安全威胁级别确定的间隔进行的。在最后一个核心赠款周期中，来自两个中心部门的十个FCCC研究计划的24个经过同行评审的研究人员使用了该设施。目前，有92％的设施使用是通过同行评审的资助调查人员。设施的使用每年增加了约10％，预计在下一个核心赠款周期中每年增加5-10％。