Irradiation

辐照

• 批准号: 6989442
• 负责人: P. JACK HOOPES
• 金额: $ 6.04万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-02 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989442
• 关键词: biomedical facility; ionizing radiation; lasers; neoplasm /cancer; radiation dosage; biomedical facility; ionizing radiation; lasers; neoplasm /cancer; radiation dosage

In past submissions the NCCC Irradiation Shared Resource has had the primary function of providing ionizing radiation for a variety of experimental conditions, including the irradiation of cells, whole animals (immunosuppression), and treatment of rodent tumors. Although these services continue, there is new emphasis on providing diagnostic and imaging technology and state-of-the-art radiation treatment planning capabilities to the Dartmouth research community. Specifically, we have added the use of KeV/orthovoltage x-ray, MeV linear accelerator and high-dose-rate (1921r) treatment irradiation capabilities. The Resource personnel also have significant experience and expertise in the use of laser-based treatments such as photodynamic therapy (PDT). Concerning research-based imaging applications, we have added dedicated digital fluoroscopy, computed tomography, diagnostic ultrasound, and in vivo fluorescent imaging. These additions have significantly broadened the focus of the Irradiation Shared Resource. The added technology will be of great benefit to the NCCC research community, especially in terms of preclinical and animal-based translational research.

在过去的提交中，NCCC辐射共享资源具有为各种实验条件提供电离辐射的主要功能，包括细胞的照射，全动物（免疫抑制）和啮齿动物肿瘤的治疗。尽管这些服务继续进行，但仍有新的重点是为达特茅斯研究社区提供诊断和成像技术以及最先进的辐射治疗计划能力。具体而言，我们添加了KEV/Orthovaltage X射线，MEV线性加速器和高剂量速率（1921R）处理辐射能力的使用。资源人员在使用基于激光的治疗（例如光动力疗法（PDT））方面也具有丰富的经验和专业知识。关于基于研究的成像应用，我们添加了专用 数字荧光镜检查，计算机断层扫描，诊断超声和体内荧光成像。这些添加大大扩大了辐射共享资源的重点。该附加技术将对NCCC研究界有很大的好处，尤其是在临床前和基于动物的转化研究方面。