A Miniaturized and High-frequency Acoustic Imaging System for Oral Health and Diseases of the Head and Neck

用于口腔健康和头颈疾病的小型化高频声学成像系统

• 批准号: 10346895
• 负责人: Jesse Vincent Jokerst
• 金额: $ 66.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-21 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10346895
• 关键词: 3-Dimensional; 3D Print; Address; Algorithms; American; Cadaver; California; Canis familiaris; Cardiovascular system; Clinical; Clinical assessments; Collaborations; Complement; Consumption; Data; Dental; Dental Care; Dental Enamel; Dental General Practice; Dentists; Devices; Diagnosis; Dimensions; Disease; Dose; Endoscopic Ultrasonography; Endoscopy; Equipment; Family suidae; Frequencies; Funding; Gingiva; Goals; Gold; Head and neck structure; Health; Health Professional; Hockey; Housing; Human; Hypoxia; Image; Imaging Device; Imaging technology; Implant; Incisor; Industrialization; Inflammation; Investments; Ionizing radiation; Jaw; Lasers; Lateral; Letters; Licensing; Light; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modality; Monitor; Mouth Diseases; Neck Disorder; Needles; Operative Surgical Procedures; Oral cavity; Oral health; Outcome; Pain; Patients; Performance; Perfusion; Periodontal Diseases; Periodontitis; Periodontium; Physiologic pulse; Prevalence; Process; Provider; Quality of life; Recording of previous events; Resolution; Risk; Source; Surface; System; Technology; Thick; Time; Tissues; Tooth Cervix; Tooth structure; Transducers; Translating; Ultrasonic Transducer; Ultrasonography; United States National Institutes of Health; Universities; Validation; Variant; Widespread Disease; Work; acoustic imaging; alveolar bone; base; bone; clinical translation; commercialization; design; health application; human data; human disease; human subject; image processing; imaging approach; imaging system; improved; in vivo imaging system; industry partner; innovation; insight; miniaturize; miniaturized device; non-invasive imaging; photoacoustic imaging; radiological imaging; soft tissue; standard of care; tool; treatment planning; ultrasound

PROJECT SUMMARY Periodontitis and oral disease are widespread with major and negative impacts on quality of life. Radiography is the standard of care in imaging but is limited to assessment of hard tissue. In the last three years, we have shown that ultrasound imaging offers significant advantages to oral health including non-invasive and real- time assessment of the periodontal probing depths, cementoenamel junction, gingival thickness, gingival perfusion/hypoxia, and clinical attachment loss. However, further clinical work in this field is limited by the large size of the ultrasound transducers—they are simply too large to access the posterior teeth. While smaller transducers exist, they cannot operate at the high frequency (>40 MHz) needed to image the small feature sizes involved in oral health. Therefore, we have established a three-way academic-industrial partnership to refine and finalize these devices for oral health. Dr. Jokerst at UCSD serves as PI and pioneered the use of photoacoustic imaging in oral health. VisualSonics Corp. is our industrial partner—Dr. Jokerst’s preliminary data was collected on VisualSonics equipment, and this company has a 20-year track record in developing high-frequency transducers including recent 510k-approved systems for human use. The clinical partner is Dr. Casey Chen who is Chair of Periodontology at USC and who will validate the system with human subjects. Aim 1 of the work will build and validate a small hockey stick-style transducer. While this design is already common, hockey stick transducers above 20 MHz are not available. Aim 2 will integrate diode lasers into the system for photoacoustic imaging to complement ultrasound. Aim 3 will develop image-processing algorithms to automatically export metrics of oral health such as clinical attachment loss and probing depth. Such automated image-processing is critical to broad clinical acceptance. Aim 4 will validate this device in healthy and diseased human subjects with comparisons to clinical gold standards. The significance of this work is based on the widespread prevalence of periodontal disease and the remarkable new insight that acoustic imaging offers in diagnosis and treatment planning. The innovative outcomes include non-invasive charting, direct measurements of the cementoenamel junction, noninvasive biotyping, and 3D maps of inflammation near implants. The work is feasible because of the track record of all three partners as well as their history of collaboration. This is a good investment for NIH because there is no miniaturized and high-frequency (>40 MHz) ultrasound transducer available despite the dramatic improvement in spatial resolution that high frequency offers. The proposal offers deliverables at all ranges of risk and the ultrasound transducer is highly likely to succeed with implications well beyond oral health: Applications in endoscopy, head and neck diseases, as well as transrectal/transvaginal imaging are obvious.

项目摘要 牙周炎和口腔疾病广泛存在，对生活质量产生重大和负面影响。射线照相 是成像中的护理标准，但仅限于对硬组织的评估。在过去的三年中，我们有 表明，超声成像为口腔健康带来了重要的优势，包括非侵入性和现实 牙周探测深度，水泥烯胺连接，牙龈厚度，牙龈的时间评估 灌注/缺氧和临床附着损失。但是，该领域的进一步临床工作受到 超声传感器的大尺寸 - 它们太大而无法进入后牙。虽然较小 存在传感器，它们不能以高频（> 40 MHz）的形象来映像小型特征 涉及口腔健康的尺寸。因此，我们建立了三向学术工业合作伙伴关系 完善并确定这些设备以进行口腔健康。 UCSD的Jokerst博士用作PI，并开创了使用 口腔健康中的光声成像。 Visualsonics Corp.是我们的工业合作伙伴。女友的初步 数据是在Visualsonics设备上收集的，该公司在开发方面有20年的记录 高频传感器，包括最近使用510k批准的人类使用系统。临床伙伴是 凯西·陈（Casey Chen）博士担任USC牙周病学主席，并将通过人类受试者验证该系统。 AIM 1的工作将构建并验证小型曲棍球棒状式传感器。虽然这个设计已经 常见的，曲棍球棒换能器20 MHz以上的换能器不可用。 AIM 2将将二极管激光器集成到 光声成像的系统以补充超声。 AIM 3将开发图像处理算法 自动出口口腔健康指标，例如临床依恋损失和探测深度。这样的 自动图像处理对于广泛的临床接受至关重要。 AIM 4将在健康中验证该设备 和患病的人类受试者与临床金标准相比。这项工作的意义是 基于牙周疾病的宽度流行率，以及声学的显着新见解 成像提供诊断和治疗计划。创新的结果包括非侵入性图表， 直接测量水泥烯胺连接，非侵入性生物分型和3D炎症地图 接近即兴。这项工作是可行的，因为所有三个伙伴的往绩以及他们的历史 合作。对于NIH来说，这是一项不错的投资，因为没有微型和高频（> 40 MHz）超声传感器可用目的地，空间分辨率的显着改善高 频率提供。该提案提供各种风险范围的可交付成果，超声传感器非常高 超出口腔健康的影响可能会成功：内窥镜检查中的应用 疾病以及经直肠/经阴道成像是明显的。