A Miniaturized Tool for Ultrasound Quantification of Periodontal Disease

牙周病超声定量的小型化工具

• 批准号: 9807257
• 负责人: Jesse Vincent Jokerst
• 金额: $ 21.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-02 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9807257
• 关键词: 3D Print; Acoustics; American; Apical; Architecture; Blinded; Cardiovascular system; Clinical; Clinical assessments; Color; Contrast Media; Data; Dental; Devices; Diagnosis; Diagnostic; Electrical Engineering; Elements; Engineering; Epithelial Attachment; Family suidae; Food; Generations; Gingiva; Goals; Gold; Health; Hemoglobin; Human; Image; Imaging Device; Imaging Phantoms; Implant; Incisor; Infection; Inflammation; Ink; Lateral; Light; Link; Maps; Measurement; Measures; Mechanics; Melanins; Methods; Microbial Biofilms; Modeling; Monitor; Optics; Oral; Oral Characters; Oral cavity; Oral health; Pain; Patients; Penetration; Performance; Periodontal Diseases; Periodontal Pocket; Periodontitis; Positioning Attribute; Procedures; Quality of life; Reference Standards; Reproducibility; Research; Resolution; Scanning; Signal Transduction; Slice; Squid; Structure of gingival sulcus; System; Techniques; Testing; Thick; Time; Tissues; Tooth structure; Toothache; Transducers; Ultrasonography; Variant; Work; base; bone; clinically significant; compliance behavior; deoxyhemoglobin; design; digital; imaging approach; improved; innovation; insight; miniaturize; nanoparticle; novel; peri-implantitis; photoacoustic imaging; prevent; prototype; soft tissue; tool

PROJECT SUMMARY The objective of this proposal is a small (ink pen-sized) tool that non-invasively measures dental pocket depths and assesses gingival health using ultrasound. We are motivated by studies showing that dental pain dramatically decreases quality of life but that nearly 50% of Americans have some form of periodontitis. Our scientific premise is that the current approach to measuring pocket depths is painful and imprecise with coefficients of variation as high as 40%. This results in poor patient compliance and poor diagnostic insight ultimately leading to attachment loss. Therefore, less painful and more accurate diagnostic tools could improve dental health and thus overall quality of life. Our preliminary data (J. Dent. Res., 2017) used an oral rinse based on the melanin nanoparticles from food-grade squid ink to map and measure the contours of the entire periodontal pocket in swine models with novel photoacoustic imaging. We noted good correlation of these image-based measurements to non-blinded conventional probe depth measurements via Bland- Altman analysis. However, the current transducer is ~20 cm by 5 cm and can only access the incisors in humans. The goal of this research is to build a smaller prototype suitable for intraoral ultrasound imaging. The aims below describe how we will build and validate this device. Aim 1 will build the device. We will combine a single element transducer and light emitting diodes into a compact pen-like design. This will use the expertise of Dr. Jokerst in acoustics and Dr. Hall in electrical engineering. Aim 2 will characterize the performance of the device using standard reference materials (imaging phantoms). We will measure the light homogeneity, axial resolution, lateral resolution, depth of penetration, frame rate, and scan time. Aim 3 will validate the ability of this device to measure the pocket depths in an ex vivo swine model. We will irrigate the pockets with a food-grade contrast agent (squid ink melanin nanoparticles) and image the pocket and surrounding gingiva. We will compare the values created by imaging to the gold-standard probe depths collected by Dr. Koka. We will evaluate the imaging data for bias and reproducibility with both methods, and we hypothesize that depths from imaging will correlate to blinded conventional periodontal probe data (R2>0.90). This work is innovative because it will quickly (2 minutes) and non-invasively map the contours of the entire dental pocket with low variance. Our preliminary data and the expertise of the research team in engineering, imaging, and periodontology underscore the feasibility of these ideas. The clinical impact will be a more reliable and less invasive tool to monitor attachment loss—this will increase patient compliance and facilitate more comprehensive estimates of attachment loss to ultimately decrease periodontitis rates. Long-term, this oral imaging tool would have many other applications in characterizing oral soft tissue including peri-implantitis and aberrant biofilms.

项目摘要 该提案的目的是一个小的（墨水大小）的工具，可无创测量牙科口袋 深度和评估超声检查牙龈健康。我们是通过研究表明牙齿的动机 疼痛大大降低了生活质量，但几乎50％的美国人患有某种形式的牙周炎。 我们的科学前提是，当前测量口袋深度的方法是痛苦的，并且暗示 变化高达40％。这会导致患者依从性差和诊断洞察力不佳 最终导致依恋损失。因此，不那么痛苦，更准确的诊断工具可以 改善牙齿健康，从而改善生活质量。我们的初步数据（J.Dent。Res。，2017）使用了口头 从食品级鱿鱼墨水中基于黑色素纳米颗粒的冲洗，以绘制并测量轮廓 带有新型光声成像的猪模型中的整个牙周口袋。我们注意到良好的相关性 这些基于图像的测量是通过平淡的非盲目常规探针深度测量 Altman分析。但是，当前的传感器约为20厘米x 5 cm，只能访问门牙 人类。这项研究的目的是构建适合口腔内超声成像的较小原型。 下面的目的描述了我们将如何构建和验证该设备。 AIM 1将构建设备。我们将组合一个元素换能器，并发出光发射二极管 紧凑的笔状设计。这将利用Acoustics Jokerst博士的专业知识和电气的Hall博士 工程。 AIM 2将使用标准参考材料来表征设备的性能 （成像幻影）。我们将测量光同质性，轴向分辨率，横向分辨率，深度 穿透，帧速率和扫描时间。 AIM 3将验证该设备测量口袋的能力 离体猪模型中的深度。我们将用食品级对比剂（鱿鱼墨水）灌溉口袋 黑色素纳米颗粒）和图像口袋和周围的牙龈。我们将比较创建的值 通过成像Koka博士收集的金标准探针深度。我们将评估成像数据的 两种方法的偏见和可重复性，我们假设成像的深度将与 盲人常规牙周探针数据（R2> 0.90）。这项工作具有创新性，因为它会很快（2 分钟），非侵入性地绘制具有较低差异的整个牙科袋的轮廓。我们的初步 数据和研究团队在工程，成像和牙周病学方面的专业知识强调了 这些想法的可行性。临床影响将是一种更可靠，更侵入性的工具 依恋损失 - 这将提高患者合规性，并促进更全面的估计 依恋损失以最终降低牙周炎率。长期，此口服成像工具将具有 在表征口腔软组织（包括植入周围炎和异常生物膜）中的许多其他应用。