A Miniaturized Tool for Ultrasound Quantification of Periodontal Disease

牙周病超声定量的小型化工具

• 批准号: 9807257
• 负责人: Jesse Vincent Jokerst
• 金额: $ 21.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-02 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9807257
• 关键词: 3D Print; Acoustics; American; Apical; Architecture; Blinded; Cardiovascular system; Clinical; Clinical assessments; Color; Contrast Media; Data; Dental; Devices; Diagnosis; Diagnostic; Electrical Engineering; Elements; Engineering; Epithelial Attachment; Family suidae; Food; Generations; Gingiva; Goals; Gold; Health; Hemoglobin; Human; Image; Imaging Device; Imaging Phantoms; Implant; Incisor; Infection; Inflammation; Ink; Lateral; Light; Link; Maps; Measurement; Measures; Mechanics; Melanins; Methods; Microbial Biofilms; Modeling; Monitor; Optics; Oral; Oral Characters; Oral cavity; Oral health; Pain; Patients; Penetration; Performance; Periodontal Diseases; Periodontal Pocket; Periodontitis; Positioning Attribute; Procedures; Quality of life; Reference Standards; Reproducibility; Research; Resolution; Scanning; Signal Transduction; Slice; Squid; Structure of gingival sulcus; System; Techniques; Testing; Thick; Time; Tissues; Tooth structure; Toothache; Transducers; Ultrasonography; Variant; Work; base; bone; clinically significant; compliance behavior; deoxyhemoglobin; design; digital; imaging approach; improved; innovation; insight; miniaturize; nanoparticle; novel; peri-implantitis; photoacoustic imaging; prevent; prototype; soft tissue; tool

PROJECT SUMMARY The objective of this proposal is a small (ink pen-sized) tool that non-invasively measures dental pocket depths and assesses gingival health using ultrasound. We are motivated by studies showing that dental pain dramatically decreases quality of life but that nearly 50% of Americans have some form of periodontitis. Our scientific premise is that the current approach to measuring pocket depths is painful and imprecise with coefficients of variation as high as 40%. This results in poor patient compliance and poor diagnostic insight ultimately leading to attachment loss. Therefore, less painful and more accurate diagnostic tools could improve dental health and thus overall quality of life. Our preliminary data (J. Dent. Res., 2017) used an oral rinse based on the melanin nanoparticles from food-grade squid ink to map and measure the contours of the entire periodontal pocket in swine models with novel photoacoustic imaging. We noted good correlation of these image-based measurements to non-blinded conventional probe depth measurements via Bland- Altman analysis. However, the current transducer is ~20 cm by 5 cm and can only access the incisors in humans. The goal of this research is to build a smaller prototype suitable for intraoral ultrasound imaging. The aims below describe how we will build and validate this device. Aim 1 will build the device. We will combine a single element transducer and light emitting diodes into a compact pen-like design. This will use the expertise of Dr. Jokerst in acoustics and Dr. Hall in electrical engineering. Aim 2 will characterize the performance of the device using standard reference materials (imaging phantoms). We will measure the light homogeneity, axial resolution, lateral resolution, depth of penetration, frame rate, and scan time. Aim 3 will validate the ability of this device to measure the pocket depths in an ex vivo swine model. We will irrigate the pockets with a food-grade contrast agent (squid ink melanin nanoparticles) and image the pocket and surrounding gingiva. We will compare the values created by imaging to the gold-standard probe depths collected by Dr. Koka. We will evaluate the imaging data for bias and reproducibility with both methods, and we hypothesize that depths from imaging will correlate to blinded conventional periodontal probe data (R2>0.90). This work is innovative because it will quickly (2 minutes) and non-invasively map the contours of the entire dental pocket with low variance. Our preliminary data and the expertise of the research team in engineering, imaging, and periodontology underscore the feasibility of these ideas. The clinical impact will be a more reliable and less invasive tool to monitor attachment loss—this will increase patient compliance and facilitate more comprehensive estimates of attachment loss to ultimately decrease periodontitis rates. Long-term, this oral imaging tool would have many other applications in characterizing oral soft tissue including peri-implantitis and aberrant biofilms.

项目概要 该提案的目标是一种小型（墨水笔大小）工具，可以非侵入性地测量牙囊 我们的动力来自研究表明牙科。 疼痛极大地降低了生活质量，但近 50% 的美国人患有某种形式的牙周炎。 我们的科学前提是，当前测量口袋深度的方法是痛苦且不精确的 变异系数高达 40%，这导致患者依从性差和诊断洞察力差。 因此，更少痛苦和更准确的诊断工具可能会导致依恋丧失。 改善牙齿健康，从而提高整体生活质量（J. Dent. Res.，2017）使用口腔。 基于食品级鱿鱼墨汁中的黑色素纳米颗粒进行冲洗，以绘制和测量黑色素的轮廓 我们发现猪模型的整个牙周袋与新型光声成像具有良好的相关性。 这些基于图像的测量通过 Bland- 非盲传统探头深度测量 然而，当前的传感器尺寸约为 20 厘米 x 5 厘米，只能接触到门牙。 这项研究的目标是构建一个适合口腔内超声成像的较小原型。 以下目标描述了我们将如何构建和验证该设备。 目标 1 将构建该设备，我们将把单个元件传感器和发光二极管组合成一个。 紧凑的笔式设计将利用 Jokerst 博士在声学方面和 Hall 博士在电气方面的专业知识。 目标 2 将使用标准参考材料来表征设备的性能。 （成像体模）我们将测量光均匀性、轴向分辨率、横向分辨率、深度。 Aim 3 将验证该设备测量口袋的能力。 我们将用食品级造影剂（乌贼墨汁）冲洗口袋。 黑色素纳米颗粒）并对牙周袋和周围牙龈进行成像，我们将比较创建的值。 通过对 Koka 博士收集的黄金标准探测深度进行成像，我们将评估成像数据。 两种方法的偏差和再现性，我们追求成像的深度将与 盲法传统牙周探针数据（R2>0.90）这项工作具有创新性，因为它会很快（2）。 分钟）并以低方差非侵入性地绘制整个牙袋的轮廓。 研究团队在工程、成像和牙周病学方面的数据和专业知识强调了 这些想法的临床影响将是一种更可靠、侵入性更小的监测工具。 依恋丧失——这将提高患者的依从性并促进更全面的评估 从长远来看，这种口腔成像工具将最终降低牙周炎的发生率。 表征口腔软组织的许多其他应用，包括种植体周围炎和异常生物膜。