CORE--IRRADIATION

核心--辐照

• 批准号: 6101990
• 负责人: P. JACK HOOPES
• 金额: --
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6101990
• 关键词: biomedical equipment resource; biomedical facility; neoplasm /cancer; neoplasm /cancer radiation therapy; oncology; radiation dosage; radiobiology

The Irradiation Shared Resource is a multi-instrument irradiation facility designed to provide high-quality irradiation and atomic absorption spectroscopy (AAS) service to NCCC cancer researchers at Dartmouth- Hitchcock Medical Center and Dartmouth College. This Shared Resource encompasses two ionizing radiation sources (137 Cesium and x-rays), and a Perkin-Elmer Model 2380 atomic absorption spectrophotometer equipped with a HGA4OO graphite furnace. The experimental irradiation of cells and rodents and the assay of serum and tissue cisplatin/carboplatin levels are principal services provided by the Resource. The ionizing irradiation and AAS components of the Irradiation Shared Resource have doubled the number of experimental irradiations and users since the previous submission in 1993. Approximately 30 NIH-funded projects used the Irradiation Shared Resource during the past year. The fiscal year l99~97 saw a four-fold increase (over any previous single year) in the number of cisplatin/carboplatin samples analyzed by the AAS component of the Resource. All these samples are related to NIH, in-house pilot, and/or collaborative corporate/academic cancer research projects. We have recently added a 2,500 sq. ft. laser laboratory facility to the Irradiation Shared Resource (no CCSG support for this component is requested). This additional laboratory, whiqh currently houses four medical-grade lasers, is located adjacent to the Cs irradiator facility; it more than doubles previous space occupied by the Irradiation Shared Resource. Once we have established a user and research track record for this facility, our goal is to incorporate the laser laboratory into a funded component of our Shared Resource.

辐射共享资源是一种多功能辐射设施，旨在为达特茅斯 - 希区柯克医学中心和达特茅斯学院的NCCC癌症研究人员提供高质量的辐照和原子吸收光谱（AAS）服务。该共享资源包括两个电离辐射源（137瓶和X射线），以及配备有HGA4OO石墨炉的Perkin-Elmer 2380型原子吸收分光光度计。细胞和啮齿动物的实验照射以及血清和组织顺铂/卡铂水平的测定是资源提供的主要服务。自1993年上一次提交以来，辐射共享资源的电离辐射和AAS组件已使实验辐射和用户的数量增加了一倍。大约30个NIH资助的项目在过去一年中使用了辐射共享资源。 L99〜97财政年度在由资源的AAS组成部分分析的顺铂/卡铂样品的数量中增加了四倍（比上一年级）。所有这些样本都与NIH，内部飞行员和/或协作公司/学术癌症研究项目有关。我们最近在辐射共享资源中添加了2500平方英尺的激光实验室设施（不需要CCSG支持该组件）。该额外的实验室WhiQH目前设有四个医用级激光器，位于CS辐照机设施附近；它使辐射共享资源占据的先前空间增加了一倍以上。一旦我们建立了该设施的用户和研究记录，我们的目标就是将激光实验室纳入我们共享资源的资助组成部分。